Details of Disease

General Information of Disease (ID: DISQKEPD)

Disease Name	Neurotrophic keratitis
Synonyms	neurotrophic keratitis
Disease Class	9A74: Neurotrophic keratitis
Definition	Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision.
Disease Hierarchy	DISB52BH: Eye disorder DISQKEPD: Neurotrophic keratitis
ICD Code	ICD-11 ICD-11: 9A74 ICD-10 ICD-10: H16.2 Expand ICD-11 '9A74 Expand ICD-10 'H16.2
Disease Identifiers	MONDO ID MONDO_0015290 UMLS CUI C0339296 MedGen ID 87384 Orphanet ID 137596 SNOMED CT ID 128080005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cenegermin	DM8Y2RU	Approved	Antibody	[1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Thymosin beta-4	DMUCMPW	Phase 3	Small molecular drug	[2]
Recombinant human nerve growth factor	DM2Z6UD	Phase 2	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SEMA3C	OTEGUY7F	Strong	Biomarker	[3]
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References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy.Diabetes. 2019 Apr;68(4):807-818. doi: 10.2337/db18-1172. Epub 2019 Jan 24.