Details of Disease

General Information of Disease (ID: DISTVVL9)

Disease Name Treatment-refractory schizophrenia
Synonyms TRS; refractory schizophrenia; treatment-refractory schizophrenia
Definition Schizophrenia which does not respond to commonly used treatments.
Disease Hierarchy
DISSRV2N: Schizophrenia
DISTVVL9: Treatment-refractory schizophrenia
Disease Identifiers
MONDO ID
MONDO_0005414
MESH ID
D000090663
UMLS CUI
C3544321
MedGen ID
1786789

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Clozapine DMFC71L Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADRA2C TT2NUT5 Strong Biomarker [2]
HTR3A TTPC4TU Strong Genetic Variation [3]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CYP2D7 OTYJTL3S Strong Genetic Variation [4]
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References

1 Clozapine FDA Label
2 An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans.Mol Psychiatry. 2001 Mar;6(2):168-72. doi: 10.1038/sj.mp.4000817.
3 Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia.Psychopharmacology (Berl). 2012 Dec;224(3):441-9. doi: 10.1007/s00213-012-2773-2. Epub 2012 Jun 15.
4 A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication.Clin Genet. 2002 Feb;61(2):152-4. doi: 10.1034/j.1399-0004.2002.610211.x.