Details of Disease

General Information of Disease (ID: DISULIZR)

Disease Name	Vulvar squamous intraepithelial lesion
Synonyms	SIN; sil; squamous intraepithelial lesion; squamous cell intraepithelial neoplasia
Disease Class	2E66: Cervical intraepithelial neoplasia
Disease Hierarchy	DISJ0JW3: Anal intraepithelial neoplasia DISKBRLI: Squamous cell neoplasm DISULIZR: Vulvar squamous intraepithelial lesion
ICD Code	ICD-11 ICD-11: 2E66.1 ICD-10 ICD-10: N87.2
Disease Identifiers	MONDO ID MONDO_0024475 UMLS CUI C0333873 MedGen ID 83092 SNOMED CT ID 24253004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
VGX-3100	DMMQ2U9	Phase 3	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PMEL	TT8MK59	moderate	Biomarker	[2]
HCN1	TTNB6UQ	Strong	Biomarker	[3]
OSMR	TTAH0KM	Strong	Altered Expression	[4]
PDXP	TT9UYG4	Strong	Genetic Variation	[5]
SERPIND1	TT8XSKJ	Strong	Biomarker	[6]
STS	TTHM0R1	Strong	Biomarker	[7]
TDO2	TTXNCBV	Strong	Altered Expression	[8]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
STIL	OT9799VN	moderate	Biomarker	[2]
CCNA1	OTX4HD45	Strong	Posttranslational Modification	[9]
EFS	OT06O7XL	Strong	Biomarker	[10]
ERCC4	OTFIOPG1	Strong	Biomarker	[11]
POLR3E	OT69PWBM	Strong	Biomarker	[10]
PSMA1	OTNBVM2U	Strong	Biomarker	[6]
PYCARD	OT67RON3	Strong	Biomarker	[7]
TCIM	OTARUXQF	Strong	Altered Expression	[12]
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⏷ Show the Full List of 8 DOT(s)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Carcinogenic HPV infection in the cervical squamo-columnar junction.J Pathol. 2015 Jul;236(3):265-71. doi: 10.1002/path.4533. Epub 2015 Apr 27.
3	Oncolytic viral therapy for cervical and ovarian cancer cells by Sindbis virus AR339 strain.Clin Cancer Res. 2005 Jun 15;11(12):4553-60. doi: 10.1158/1078-0432.CCR-04-2610.
4	Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome.J Pathol. 2007 Jul;212(3):325-34. doi: 10.1002/path.2184.
5	Persistent high-risk human papillomavirus infections and other end-point markers of progressive cervical disease among women prospectively followed up in the New Independent States of the Former Soviet Union and the Latin American Screening study cohorts.Int J Gynecol Cancer. 2009 Jul;19(5):934-42. doi: 10.1111/IGC.0b013e3181a834fe.
6	HPV oligonucleotide microarray-based detection of HPV genotypes in cervical neoplastic lesions.Gynecol Oncol. 2003 May;89(2):210-7. doi: 10.1016/s0090-8258(02)00069-0.
7	Correlation of histopathologic/cytologic follow-up findings with vaginal ASC-US and ASC-H Papanicolaou test and HPV test results.Am J Clin Pathol. 2012 Mar;137(3):437-43. doi: 10.1309/AJCP9TO1OMXLDDPI.
8	Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.Cancer Cytopathol. 2019 Sep;127(9):586-597. doi: 10.1002/cncy.22172. Epub 2019 Aug 14.
9	CCNA1 promoter methylation: a potential marker for grading Papanicolaou smear cervical squamous intraepithelial lesions.Asian Pac J Cancer Prev. 2014;15(18):7971-5. doi: 10.7314/apjcp.2014.15.18.7971.
10	New - and SIN -retrovectors for safe transduction and specific transgene expression in pancreatic cell lines.BMC Biotechnol. 2019 Jun 17;19(1):35. doi: 10.1186/s12896-019-0531-9.
11	Single nucleotide polymorphisms in the DNA repair genes in HPV-positive cervical cancer.Eur J Cancer Prev. 2016 May;25(3):224-31. doi: 10.1097/CEJ.0000000000000159.
12	Association of C8orf4 expression with its methylation status, aberrant -catenin expression, and the development of cervical squamous cell carcinoma.Medicine (Baltimore). 2019 Aug;98(31):e16715. doi: 10.1097/MD.0000000000016715.