Details of Disease

General Information of Disease (ID: DISWPOOE)

Disease Name Purpura
Synonyms purpuric disorder; purpura (disease); purpura
Definition
A small blood vessel hemorrhage into the skin and/or mucous membranes. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.
Disease Hierarchy
DIS27CUA: Bleeding disorder
DISWPOOE: Purpura
Disease Identifiers
MONDO ID
MONDO_0002610
MESH ID
D011693
UMLS CUI
C0034150
MedGen ID
19584
HPO ID
HP:0000979
SNOMED CT ID
12393003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADAMTS13 TTUREBK moderate Biomarker [1]
CTLA4 TTI2S1D moderate Genetic Variation [2]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PTPN22 OTDCNTC3 moderate Genetic Variation [3]
NPHS2 OTLCNUII Strong Biomarker [4]
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References

1 Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura.Blood. 2004 Jun 15;103(12):4514-9. doi: 10.1182/blood-2003-12-4165. Epub 2004 Feb 19.
2 CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schnlein purpura.Pediatr Nephrol. 2008 Aug;23(8):1239-44. doi: 10.1007/s00467-008-0837-7. Epub 2008 May 1.
3 Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to Henoch-Schnlein purpura.Clin Exp Rheumatol. 2007 Sep-Oct;25(5):750-3.
4 Lack of association between NPHS2 gene polymorphisms and Henoch-Schnlein purpura nephritis.Arch Dermatol Res. 2007 Jun;299(3):151-5. doi: 10.1007/s00403-007-0752-y. Epub 2007 Mar 29.