Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEC7JEF)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; HMPREF3277_11020
Gene Name	HMPREF3277_11020
UniProt ID	A0A1S1G219_9NEIS
INTEDE ID	DME1227
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Neisseria sicca Kingdom: Bacteria Phylum: Proteobacteria Class: Betaproteobacteria Order: Neisseriales Family: Neisseriaceae Genus: Neisseria Species: Neisseria sicca
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MKPAQTSLLFALLLGLLPAAYAEDYDDEAYQNLITQCTRNQLDSCVTLGIWTRDYLESPA DAYLPLKKACDGKNMKGCNVLANLYLDPYSGLGMDYSKALELYRKACKGGYDNACRNAKE TEQEMRSQTAEDRAVKRQERLEALQRSCMGENDAACRALQRELQR
Function	This enzyme hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[2]
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References

1	Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
2	Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.