Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DENJ2SQ)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase type 2a; Carbapenem and cephamycin resistance; CCRA; Imipenem-cefoxitin hydrolyzing enzyme; Metallo-beta-lactamase type IIa; Zinc-requiring beta-lactamase; ccrA; cfiA
Gene Name	ccrA
UniProt ID	BLAB_BACFG
INTEDE ID	DME1095
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Bacteroides fragilis Kingdom: Bacteria Phylum: Bacteroidetes Class: Bacteroidia Order: Bacteroidales Family: Bacteroidaceae Genus: Bacteroides Species: Bacteroides fragilis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVI NNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYA NQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGG CMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVN QYIESTSKP
Function	This enzyme confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

4 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[2]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[1], [2]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[1]
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1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[3]
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References

1	Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
2	Antibacterial activity of cefoperazone against anaerobic bacteria (author's transl). Jpn J Antibiot. 1980 Nov;33(11):1171-82.
3	Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9.