Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT90D4M0)

DOT Name Protein MIS12 homolog (MIS12)
Gene Name MIS12
UniProt ID
MIS12_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
5LSJ; 5LSK
Pfam ID
PF05859
Sequence
MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQI
RKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKE
IEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVS
LVQNSRKLQNIRDNVEKESKRLKIS
Function Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Reactome Pathway
Separation of Sister Chromatids (R-HSA-2467813 )
Resolution of Sister Chromatid Cohesion (R-HSA-2500257 )
RHO GTPases Activate Formins (R-HSA-5663220 )
Mitotic Prometaphase (R-HSA-68877 )
EML4 and NUDC in mitotic spindle formation (R-HSA-9648025 )
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
5 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the expression of Protein MIS12 homolog (MIS12). [1]
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Protein MIS12 homolog (MIS12). [2]
Selenium DM25CGV Approved Selenium decreases the expression of Protein MIS12 homolog (MIS12). [3]
Cannabidiol DM0659E Approved Cannabidiol increases the expression of Protein MIS12 homolog (MIS12). [4]
Tocopherol DMBIJZ6 Phase 2 Tocopherol decreases the expression of Protein MIS12 homolog (MIS12). [3]
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References

1 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
2 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
3 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
4 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.