Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUL6GWP)

DOT Name Putative uncharacterized protein C19orf73 (C19ORF73)
Gene Name C19ORF73
UniProt ID
CS073_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF17692
Sequence
MRLKVGFQGGGCFRKDALCLEGGVSARWARAPHSAPLRPPRELHAAPPPATPTQTVVRPA
GFPRRTRLMVRSAPPTQRPPTGSGCVSGLWRKGLGLRPQTLLRVGSVVLSSAPALRPRLG
PCLRPPPSD

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Putative uncharacterized protein C19orf73 (C19ORF73). [1]
Tocopherol DMBIJZ6 Phase 2 Tocopherol increases the expression of Putative uncharacterized protein C19orf73 (C19ORF73). [2]
Milchsaure DM462BT Investigative Milchsaure decreases the expression of Putative uncharacterized protein C19orf73 (C19ORF73). [3]
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References

1 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
2 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
3 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.