Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTY3GTEP)

• DOT Name: Proline, histidine and glycine-rich protein 1 (PHGR1)
• Gene Name: PHGR1
• Related Disease:
  Colon cancer
  Colon carcinoma
  Colonic disorder
  Colorectal carcinoma
  Metastatic malignant neoplasm
  Poikiloderma with neutropenia
• UniProt ID: PHGR1_HUMAN
• Sequence:
  MDPGPKGHCHCGGHGHPPGHCGPPPGHGPGPCGPPPHHGPGPCGPPPGHGPGPCGPPPHH
  GPGPCGPPPGHGPGHPPPGPHH

Molecular Interaction Atlas (MIA) of This DOT

6 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Colon cancer	DISVC52G	Strong	Altered Expression	[1]
Colon carcinoma	DISJYKUO	Strong	Altered Expression	[1]
Colonic disorder	DISXXS3L	Strong	Altered Expression	[1]
Colorectal carcinoma	DIS5PYL0	Strong	Altered Expression	[2]
Metastatic malignant neoplasm	DIS86UK6	Strong	Altered Expression	[1]
Poikiloderma with neutropenia	DIS20E3L	Strong	Altered Expression	[1]

4 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Proline, histidine and glycine-rich protein 1 (PHGR1).	[3]
Calcitriol	DM8ZVJ7	Approved	Calcitriol increases the expression of Proline, histidine and glycine-rich protein 1 (PHGR1).	[4]
Testosterone	DM7HUNW	Approved	Testosterone increases the expression of Proline, histidine and glycine-rich protein 1 (PHGR1).	[4]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Proline, histidine and glycine-rich protein 1 (PHGR1).	[6]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Proline, histidine and glycine-rich protein 1 (PHGR1).	[5]

References

• [1] The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer.Transl Oncol. 2018 Apr;11(2):436-443. doi: 10.1016/j.tranon.2018.01.015. Epub 2018 Feb 21.
• [2] Expression profiling and intracellular localization studies of the novel Proline-, Histidine-, and Glycine-rich protein 1 suggest an essential role in gastro-intestinal epithelium and a potential clinical application in colorectal cancer diagnostics.BMC Gastroenterol. 2018 Feb 7;18(1):26. doi: 10.1186/s12876-018-0752-8.
• [3] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [4] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [5] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [6] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.