Details of the Drug Combination

General Information of Drug Combination (ID: DC5W95F)

• Drug Combination Name: Itraconazole + Mifepristone
• Indication: Drug Interaction Potentiation; Status: Phase 1 [1]
• Component Drugs:
  Itraconazole (DMCR1MV): Small molecular drug
  Mifepristone (DMGZQEF): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Itraconazole

Disease Entry	ICD 11	Status	REF
Aspergillosis	1F20	Approved	[2]
Blastomycosis	1F22	Approved	[2]
Fungal infection	1F29-1F2F	Approved	[3]
Fusariosis	N.A.	Approved	[2]
Histoplasmosis	N.A.	Approved	[2]
Invasive candidiasis	1F23	Approved	[2]
Mycoses	1F2Z	Approved	[2]
Candidemia	1F23.3Y	Investigative	[2]
Esophageal candidiasis	N.A.	Investigative	[2]

Itraconazole Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Hedgehog signaling pathway (HS pathway)	TT4LXBC	NOUNIPROTAC	Inhibitor	[5]
Candida Cytochrome P450 51 (Candi ERG11)	TTTSOUD	CP51_CANAL	Modulator	[6]

Itraconazole Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[7]

Itraconazole Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[8]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[9]

Itraconazole Interacts with 10 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Expression	[10]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Activity	[11]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Decreases Activity	[12]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[13]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[14]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[15]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[16]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Expression	[16]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Decreases Activity	[17]
Lanosterol 14-alpha demethylase (CYP51A1)	OTAYHG9C	CP51A_HUMAN	Decreases Response To Substance	[18]

Indication(s) of Mifepristone

Disease Entry	ICD 11	Status	REF
Cushing disease	5A70	Approved	[4]

Mifepristone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[21]

Mifepristone Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[22]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[23]

Mifepristone Interacts with 228 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[24]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Increases ADR	[25]
Nuclear receptor subfamily 1 group I member 3 (NR1I3)	OTS3SGH7	NR1I3_HUMAN	Increases Expression	[26]
Frizzled-9 (FZD9)	OTTZ9MKK	FZD9_HUMAN	Increases Expression	[19]
Forkhead box protein N3 (FOXN3)	OTOJYJZP	FOXN3_HUMAN	Increases Expression	[19]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Increases Expression	[19]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Increases Expression	[19]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Increases Expression	[19]
Histone-lysine N-methyltransferase 2D (KMT2D)	OTTVHCLY	KMT2D_HUMAN	Decreases Expression	[19]
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6)	OTSB55D2	H17B6_HUMAN	Decreases Expression	[19]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)	OT8L6EGI	BCAT2_HUMAN	Decreases Expression	[19]
Calpain-5 (CAPN5)	OTQ8QM7K	CAN5_HUMAN	Decreases Expression	[19]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Decreases Expression	[19]
Septin-4 (SEPTIN4)	OTD16B30	SEPT4_HUMAN	Decreases Expression	[19]
Cationic amino acid transporter 4 (SLC7A4)	OTAVC6QS	CTR4_HUMAN	Decreases Expression	[19]
Proline dehydrogenase 1, mitochondrial (PRODH)	OT7SQ1C7	PROD_HUMAN	Decreases Expression	[19]
Synaptogyrin-1 (SYNGR1)	OT0MBUK5	SNG1_HUMAN	Decreases Expression	[19]
C-X-C motif chemokine 13 (CXCL13)	OT2AT4N8	CXL13_HUMAN	Decreases Expression	[19]
Frizzled-6 (FZD6)	OTBCPII8	FZD6_HUMAN	Increases Expression	[19]
Sushi repeat-containing protein SRPX2 (SRPX2)	OT6A63TX	SRPX2_HUMAN	Increases Expression	[19]
Sorting nexin-2 (SNX2)	OT889MQA	SNX2_HUMAN	Increases Expression	[19]
P antigen family member 4 (PAGE4)	OT2VLWT0	PAGE4_HUMAN	Decreases Expression	[19]
Slit homolog 3 protein (SLIT3)	OTU8MKEU	SLIT3_HUMAN	Decreases Expression	[19]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Decreases Expression	[19]
Solute carrier family 22 member 3 (SLC22A3)	OTQYGVXX	S22A3_HUMAN	Decreases Expression	[19]
E3 ubiquitin-protein ligase NEURL1 (NEURL1)	OT2C4P70	NEUL1_HUMAN	Increases Expression	[19]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Decreases Expression	[19]
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)	OTDSN5XF	B3GA3_HUMAN	Decreases Expression	[19]
Myelin protein zero-like protein 1 (MPZL1)	OTJSUUHR	MPZL1_HUMAN	Decreases Expression	[19]
Supervillin (SVIL)	OTWQQ1WK	SVIL_HUMAN	Increases Expression	[19]
Follistatin-related protein 3 (FSTL3)	OT75489W	FSTL3_HUMAN	Decreases Expression	[19]
Protein LDOC1 (LDOC1)	OTWZH4O9	LDOC1_HUMAN	Decreases Expression	[19]
Coagulation factor XIII A chain (F13A1)	OTO8O184	F13A_HUMAN	Increases Expression	[19]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[19]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[19]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[19]
Collagen alpha-1(II) chain (COL2A1)	OT5E59C8	CO2A1_HUMAN	Decreases Expression	[19]
Apolipoprotein C-I (APOC1)	OTA58CED	APOC1_HUMAN	Decreases Expression	[19]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Increases Expression	[19]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Decreases Expression	[19]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[19]
Protein S100-A6 (S100A6)	OTHHPZQ8	S10A6_HUMAN	Decreases Expression	[19]
Tyrosine 3-monooxygenase (TH)	OT6ZORKP	TY3H_HUMAN	Decreases Expression	[19]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Increases Expression	[19]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Increases Expression	[19]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Increases Expression	[19]
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Increases Expression	[19]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Increases Expression	[19]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[19]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Increases Expression	[19]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[19]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Decreases Expression	[19]
Glutathione S-transferase theta-2 (GSTT2)	OTANW3TJ	GST2_HUMAN	Decreases Expression	[19]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[19]
Thyroid hormone receptor alpha (THRA)	OTKRLVD7	THA_HUMAN	Decreases Expression	[19]
Thyroid hormone receptor beta (THRB)	OTBBIRHZ	THB_HUMAN	Increases Expression	[19]
Pyruvate carboxylase, mitochondrial (PC)	OT6O0V51	PYC_HUMAN	Decreases Expression	[19]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Decreases Expression	[19]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[19]
Cytochrome P450 4B1 (CYP4B1)	OTJP46CB	CP4B1_HUMAN	Decreases Expression	[19]
Retinoic acid receptor gamma (RARG)	OT8LHMDH	RARG_HUMAN	Decreases Expression	[19]
HLA class II histocompatibility antigen, DO beta chain (HLA-DOB)	OTKADDUB	DOB_HUMAN	Decreases Expression	[19]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Decreases Expression	[19]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Decreases Expression	[19]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Decreases Expression	[19]
Platelet glycoprotein 4 (CD36)	OT5CZWKY	CD36_HUMAN	Decreases Expression	[19]
Fumarylacetoacetase (FAH)	OTGZA1YR	FAAA_HUMAN	Decreases Expression	[19]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Increases Expression	[19]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Increases Expression	[19]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases Expression	[19]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Decreases Expression	[19]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Expression	[19]
Integrin alpha-6 (ITGA6)	OT3FA39C	ITA6_HUMAN	Increases Expression	[19]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Decreases Expression	[19]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[19]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[19]
Atypical chemokine receptor 3 (ACKR3)	OTA6GA4F	ACKR3_HUMAN	Decreases Expression	[19]
Collagen alpha-5(IV) chain (COL4A5)	OTHG60RE	CO4A5_HUMAN	Decreases Expression	[19]
ER lumen protein-retaining receptor 2 (KDELR2)	OT9QW7Q0	ERD22_HUMAN	Increases Expression	[19]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[19]
Pigment epithelium-derived factor (SERPINF1)	OTWZH98J	PEDF_HUMAN	Decreases Expression	[19]
Prostaglandin-H2 D-isomerase (PTGDS)	OT71NN7C	PTGDS_HUMAN	Decreases Expression	[19]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Increases Expression	[19]
Glutamate receptor 1 (GRIA1)	OT85LOCJ	GRIA1_HUMAN	Decreases Expression	[19]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[19]
Prostacyclin receptor (PTGIR)	OTWTABYM	PI2R_HUMAN	Increases Expression	[19]
Small ribosomal subunit protein eS10 (RPS10)	OTE3VSAH	RS10_HUMAN	Increases Expression	[19]
Microtubule-associated protein 1B (MAP1B)	OTVXW089	MAP1B_HUMAN	Increases Expression	[19]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Increases Expression	[19]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Increases Expression	[19]
Heat shock 70 kDa protein 13 (HSPA13)	OTYXMC4G	HSP13_HUMAN	Increases Expression	[19]
DNA polymerase delta subunit 2 (POLD2)	OTBNASP6	DPOD2_HUMAN	Decreases Expression	[19]
MARCKS-related protein (MARCKSL1)	OT13J2FM	MRP_HUMAN	Increases Expression	[19]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[19]
ADP-ribosylation factor-like protein 4D (ARL4D)	OTG5I3KU	ARL4D_HUMAN	Decreases Expression	[19]
Matrix metalloproteinase-14 (MMP14)	OT9C197Z	MMP14_HUMAN	Increases Expression	[19]
Matrix metalloproteinase-16 (MMP16)	OTSFQ2BJ	MMP16_HUMAN	Increases Expression	[19]
RNA-binding protein Nova-1 (NOVA1)	OT6A9KHY	NOVA1_HUMAN	Increases Expression	[19]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Increases Expression	[19]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Increases Expression	[19]
Cadherin-11 (CDH11)	OTIZKPTF	CAD11_HUMAN	Increases Expression	[19]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Expression	[19]
Sestrin-3 (SESN3)	OTJRY1Y5	SESN3_HUMAN	Increases Expression	[19]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[19]
Ras-related protein Rap-1b (RAP1B)	OTHEIIMM	RAP1B_HUMAN	Increases Expression	[19]
26S proteasome regulatory subunit 10B (PSMC6)	OTG8997V	PRS10_HUMAN	Increases Expression	[19]
Large ribosomal subunit protein eL39 (RPL39)	OTL8TZHQ	RL39_HUMAN	Increases Expression	[19]
Contactin-associated protein 1 (CNTNAP1)	OT5Y03EU	CNTP1_HUMAN	Decreases Expression	[19]
Fractalkine (CX3CL1)	OTPLGI0E	X3CL1_HUMAN	Increases Expression	[19]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Decreases Expression	[19]
C-C motif chemokine 8 (CCL8)	OTCTWYN8	CCL8_HUMAN	Decreases Expression	[19]
Rho-related GTP-binding protein RhoG (RHOG)	OTJ7J1WA	RHOG_HUMAN	Decreases Expression	[19]
Small EDRK-rich factor 2 (SERF2)	OTZQDYCZ	SERF2_HUMAN	Increases Expression	[19]
Norrin (NDP)	OTGDJ4US	NDP_HUMAN	Decreases Expression	[19]
Angiopoietin-1 receptor (TEK)	OT78YN57	TIE2_HUMAN	Increases Expression	[19]
Tyrosine-protein kinase BTK (BTK)	OTG3CDVK	BTK_HUMAN	Increases Expression	[19]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)	OTSK5GFC	P2R3A_HUMAN	Increases Expression	[19]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Increases Expression	[19]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Increases Expression	[19]
Sperm-associated antigen 1 (SPAG1)	OT29JZKW	SPAG1_HUMAN	Increases Expression	[19]
ATP-binding cassette sub-family C member 8 (ABCC8)	OTCWQ54I	ABCC8_HUMAN	Decreases Expression	[19]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)	OTTA5C3U	AIMP1_HUMAN	Increases Expression	[19]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)	OTVZD4H6	BNIP2_HUMAN	Increases Expression	[19]
Metastasis-associated protein MTA1 (MTA1)	OTBHW3S9	MTA1_HUMAN	Decreases Expression	[19]
Phospholipase D1 (PLD1)	OTMVUKW6	PLD1_HUMAN	Increases Expression	[19]
Laminin subunit gamma-2 (LAMC2)	OTJMTM72	LAMC2_HUMAN	Increases Expression	[19]
Collagen alpha-6(IV) chain (COL4A6)	OTUREU5Z	CO4A6_HUMAN	Decreases Expression	[19]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Increases Expression	[19]
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1)	OT536XAV	AR6P1_HUMAN	Increases Expression	[19]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK)	OTAP5AT3	PTPRK_HUMAN	Increases Expression	[19]
P2Y purinoceptor 14 (P2RY14)	OTDGZKED	P2Y14_HUMAN	Increases Expression	[19]
Monocyte to macrophage differentiation factor (MMD)	OTB5I4OC	PAQRB_HUMAN	Increases Expression	[19]
TSC22 domain family protein 1 (TSC22D1)	OTN4GFWD	T22D1_HUMAN	Increases Expression	[19]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Decreases Expression	[19]
Mitogen-activated protein kinase 6 (MAPK6)	OTDDNF3Q	MK06_HUMAN	Increases Expression	[19]
Laminin subunit alpha-3 (LAMA3)	OTFME7HT	LAMA3_HUMAN	Decreases Expression	[19]
Centrosomal protein kizuna (KIZ)	OT5VCKSM	KIZ_HUMAN	Increases Expression	[19]
Carboxypeptidase Z (CPZ)	OT5HUR28	CBPZ_HUMAN	Increases Expression	[19]
F-box only protein 46 (FBXO46)	OT773EPG	FBX46_HUMAN	Decreases Expression	[19]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Increases Expression	[19]
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6)	OTAX8BNJ	B3GN6_HUMAN	Decreases Expression	[19]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)	OTZ4BG4B	PARPT_HUMAN	Decreases Expression	[19]
Kinesin-like protein KIF27 (KIF27)	OTV70I2Q	KIF27_HUMAN	Increases Expression	[19]
Osteopetrosis-associated transmembrane protein 1 (OSTM1)	OTKNJDH7	OSTM1_HUMAN	Increases Expression	[19]
Membrane progestin receptor alpha (PAQR7)	OTIWX5AM	PAQR7_HUMAN	Decreases Expression	[19]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[19]
RB1-inducible coiled-coil protein 1 (RB1CC1)	OTZK8PFX	RBCC1_HUMAN	Increases Expression	[19]
Protein phosphatase 1 regulatory subunit 1C (PPP1R1C)	OTVH6BND	PPR1C_HUMAN	Increases Expression	[19]
Kelch-like protein 6 (KLHL6)	OTLDECOX	KLHL6_HUMAN	Increases Expression	[19]
C-type lectin domain family 2 member B (CLEC2B)	OT0W0M0L	CLC2B_HUMAN	Increases Expression	[19]
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Decreases Expression	[19]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Increases Expression	[19]
Histone deacetylase 2 (HDAC2)	OTUYVFKN	HDAC2_HUMAN	Increases Expression	[19]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Increases Expression	[19]
Stathmin-2 (STMN2)	OT0FUHLH	STMN2_HUMAN	Increases Expression	[19]
Seipin (BSCL2)	OT73V6Y4	BSCL2_HUMAN	Decreases Expression	[19]
Receptor expression-enhancing protein 6 (REEP6)	OTY4FPO8	REEP6_HUMAN	Decreases Expression	[19]
Mannose-1-phosphate guanyltransferase alpha (GMPPA)	OTADC03N	GMPPA_HUMAN	Decreases Expression	[19]
Mastermind-like protein 3 (MAML3)	OTZFV53Z	MAML3_HUMAN	Increases Expression	[19]
Translocation protein SEC62 (SEC62)	OTCWEL5F	SEC62_HUMAN	Increases Expression	[19]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)	OTVFRL8G	TI17A_HUMAN	Increases Expression	[19]
C-C motif chemokine 13 (CCL13)	OTNX0JD0	CCL13_HUMAN	Decreases Expression	[19]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)	OTQW6R3Z	SGIP1_HUMAN	Increases Expression	[19]
Receptor expression-enhancing protein 2 (REEP2)	OTPCRA5O	REEP2_HUMAN	Decreases Expression	[19]
Latexin (LXN)	OTZQ2M6Y	LXN_HUMAN	Increases Expression	[19]
Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6)	OT57EPQC	C1QT6_HUMAN	Increases Expression	[19]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Decreases Expression	[19]
E3 ubiquitin-protein ligase SMURF2 (SMURF2)	OT3TRVL7	SMUF2_HUMAN	Increases Expression	[19]
Netrin-4 (NTN4)	OTDRRMP3	NET4_HUMAN	Increases Expression	[19]
Endothelial cell-specific molecule 1 (ESM1)	OT331Y8V	ESM1_HUMAN	Increases Expression	[19]
Exosome complex component RRP46 (EXOSC5)	OTADUQ7H	EXOS5_HUMAN	Decreases Expression	[19]
Protein reprimo (RPRM)	OTNNBAS1	RPRM_HUMAN	Decreases Expression	[19]
E3 ubiquitin-protein ligase RNF146 (RNF146)	OTE4CO7E	RN146_HUMAN	Increases Expression	[19]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Decreases Expression	[19]
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6)	OT70T27A	CKLF6_HUMAN	Increases Expression	[19]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Increases Expression	[19]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Decreases Expression	[19]
Sentrin-specific protease 1 (SENP1)	OTO8J4VV	SENP1_HUMAN	Increases Expression	[19]
Phosphatidylethanolamine N-methyltransferase (PEMT)	OTKXRUL9	PEMT_HUMAN	Decreases Expression	[19]
DnaJ homolog subfamily B member 9 (DNAJB9)	OT38EQT6	DNJB9_HUMAN	Increases Expression	[19]
Alpha-catulin (CTNNAL1)	OTESJ6JD	CTNL1_HUMAN	Increases Expression	[19]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)	OT9PBQVT	SIA7B_HUMAN	Increases Expression	[19]
Polypyrimidine tract-binding protein 2 (PTBP2)	OTF4S7NE	PTBP2_HUMAN	Increases Expression	[19]
Frizzled-4 (FZD4)	OTGLZIE0	FZD4_HUMAN	Increases Expression	[19]
Frizzled-10 (FZD10)	OTSAENLT	FZD10_HUMAN	Increases Expression	[19]
Lysosomal thioesterase PPT2 (PPT2)	OTD5VJ9A	PPT2_HUMAN	Increases Expression	[19]
Sorting nexin-12 (SNX12)	OTARRSWB	SNX12_HUMAN	Decreases Expression	[19]
HIG1 domain family member 1A, mitochondrial (HIGD1A)	OTS351DV	HIG1A_HUMAN	Increases Expression	[19]
Band 4.1-like protein 3 (EPB41L3)	OTS6CHG2	E41L3_HUMAN	Increases Expression	[19]
Long-chain fatty acid transport protein 5 (SLC27A5)	OT4OK511	S27A5_HUMAN	Decreases Expression	[19]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Increases Expression	[19]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2)	OTYOTM2B	NUBP2_HUMAN	Increases Expression	[19]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Decreases Expression	[19]
Calcineurin-binding protein cabin-1 (CABIN1)	OT4G5CIK	CABIN_HUMAN	Increases Expression	[19]
SEC23-interacting protein (SEC23IP)	OTTZ0FXP	S23IP_HUMAN	Increases Expression	[19]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Increases Expression	[27]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Decreases Expression	[28]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[29]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Expression	[30]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[31]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Decreases Expression	[32]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[33]
T-cell surface glycoprotein CD4 (CD4)	OT7Z5LNF	CD4_HUMAN	Decreases Expression	[34]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Secretion	[35]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Activity	[36]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Decreases Activity	[37]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[38]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Activity	[39]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[40]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[41]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Decreases Expression	[42]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Activity	[33]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Decreases Expression	[38]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[43]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[44]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[40]
Cathelicidin antimicrobial peptide (CAMP)	OT3Y8011	CAMP_HUMAN	Decreases Expression	[32]
Forkhead box protein L2 (FOXL2)	OTFRQUYL	FOXL2_HUMAN	Increases Expression	[44]
Neutrophil defensin 1 (DEFA1)	OT5N1B9B	DEF1_HUMAN	Decreases Expression	[32]
Neutrophil defensin 3 (DEFA3)	OTO3N8E1	DEF3_HUMAN	Decreases Expression	[32]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Decreases Expression	[41]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[40]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Increases Expression	[45]
Progesterone-induced-blocking factor 1 (PIBF1)	OTCBT1A1	PIBF1_HUMAN	Decreases Expression	[32]
Interleukin-1 receptor-associated kinase 4 (IRAK4)	OT9JTJWC	IRAK4_HUMAN	Decreases Expression	[32]
Toll-like receptor 7 (TLR7)	OT3HZV7Z	TLR7_HUMAN	Decreases Expression	[32]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Increases Response To Substance	[46]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Increases Response To Substance	[46]

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