Details of the Drug Combination

General Information of Drug Combination (ID: DCKEV60)

Drug Combination Name
Anastrozole Vincristine
Indication
Disease Entry Status REF
Invasive ductal carcinoma Investigative [1]
Component Drugs Anastrozole   DMNP60F Vincristine   DMINOX3
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: BT-549
Zero Interaction Potency (ZIP) Score: 1.98
Bliss Independence Score: 3.74
Loewe Additivity Score: 3.79
LHighest Single Agent (HSA) Score: 5.86

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Anastrozole
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [2]
Estrogen-receptor positive breast cancer N.A. Approved [3]
Obesity 5B81 Approved [3]
Anastrozole Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [6]
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Anastrozole Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7) DT2EGUN S38A7_HUMAN Substrate [7]
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Anastrozole Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [8]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [8]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Metabolism [8]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [8]
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⏷ Show the Full List of 6 DME(s)
Anastrozole Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Adenylate kinase isoenzyme 1 (AK1) OT614AR3 KAD1_HUMAN Increases ADR [9]
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Indication(s) of Vincristine
Disease Entry ICD 11 Status REF
Acute lymphoblastic leukaemia 2A85 Approved [4]
Adult kidney Wilms tumor N.A. Approved [5]
Beckwith-Wiedemann syndrome N.A. Approved [5]
Burkitt lymphoma N.A. Approved [5]
Central nervous system neoplasm N.A. Approved [5]
Childhood acute lymphoblastic leukemia N.A. Approved [5]
Childhood kidney Wilms tumor N.A. Approved [5]
Hamartoma N.A. Approved [5]
Kidney neoplasm N.A. Approved [5]
Leukemia N.A. Approved [5]
MALT lymphoma N.A. Approved [5]
Nodal marginal zone lymphoma 2A85.0 Approved [5]
Plasma cell myeloma 2A83.1 Approved [5]
Primitive neuroectodermal tumor N.A. Approved [5]
Splenic marginal zone lymphoma N.A. Approved [5]
Testicular lymphoma N.A. Approved [5]
Wilms tumor N.A. Approved [5]
Classic Hodgkin lymphoma N.A. Investigative [5]
Follicular lymphoma 2A80 Investigative [5]
Neuroblastoma 2D11.2 Investigative [5]
Vincristine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Tubulin beta (TUBB) TTYFKSZ NOUNIPROTAC Modulator [10]
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Vincristine Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [11]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [12]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [13]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [14]
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Vincristine Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [15]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [16]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DCDE3F9 A549 Investigative [17]
Adenocarcinoma DC0KO9Y HCT-15 Investigative [17]
Adenocarcinoma DCUG9B3 SW-620 Investigative [17]
Adenocarcinoma DCFZD1N HCT116 Investigative [17]
Adenocarcinoma DC9O1VM HT29 Investigative [17]
Amelanotic melanoma DC3I1QA M14 Investigative [17]
Astrocytoma DCUWS8K SNB-19 Investigative [17]
Chronic myelogenous leukemia DCCBQ7Y K-562 Investigative [17]
Clear cell renal cell carcinoma DCA8ZI7 TK-10 Investigative [17]
Clear cell renal cell carcinoma DCINFPH 786-0 Investigative [17]
Clear cell renal cell carcinoma DCJ9656 A498 Investigative [17]
Glioma DCSGKBT SF-295 Investigative [17]
High grade ovarian serous adenocarcinoma DCMB0CR OVCAR-4 Investigative [17]
High grade ovarian serous adenocarcinoma DCET9P5 NCI\\/ADR-RES Investigative [17]
Large cell lung carcinoma DCGFMQ3 NCI-H460 Investigative [17]
Lung adenocarcinoma DCIFU9Q HOP-62 Investigative [17]
Minimally invasive lung adenocarcinoma DC2X725 NCI-H322M Investigative [17]
Ovarian serous cystadenocarcinoma DC5UJ1M SK-OV-3 Investigative [17]
Pleural epithelioid mesothelioma DCFZP9V NCI-H226 Investigative [17]
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⏷ Show the Full List of 19 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5137).
3 Anastrozole FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6785).
5 Vincristine FDA Label
6 Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. J Pediatr Endocrinol Metab. 2002;15 Suppl 3:945-8.
7 Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. Clin Pharmacol Ther. 2019 Jan 16.
8 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
11 Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol. 2008 Sep 4;591(1-3):128-31.
12 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
13 L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.
14 Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34.
15 Association of CYP3A5 expression and vincristine neurotoxicity in pediatric malignancies in Turkish population. J Pediatr Hematol Oncol. 2017 Aug;39(6):458-462.
16 Drug Interactions Flockhart Table
17 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966