Details of the Drug Combinations

General Information of This Drug (ID: DM6BZCV)

Drug Name
Sivelestat   DM6BZCV
Synonyms
127373-66-4; UNII-DWI62G0P59; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; Elastase Inhibitor IV; C20H22N2O7S; N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid; Sivelestat (ONO-5046); LY544349; CHEMBL76688; LY 544349; DWI62G0P59; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-; N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Phase 3 [1]
Multiple sclerosis 8A40 Phase 3 [1]
Psoriatic arthritis FA21 Phase 3 [1]
Pyoderma gangrenosum EB21 Phase 3 [2]
Rheumatoid arthritis FA20 Phase 3 [1]
Ulcerative colitis DD71 Phase 3 [1]
Anterior uveitis 9A96 Application submitted [3]
Axial spondyloarthritis FA92.0 Application submitted [1]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

58 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Sivelestat DCFBMTL Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Acitretin + Sivelestat DC1N64N Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Asenapine + Sivelestat DC42KUB Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
BHV-0223 + Sivelestat DCIL2ES BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Brincidofovir + Sivelestat DC8UTCM Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
BRL-15572 + Sivelestat DC6X1JD BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Buspirone + Sivelestat DCCRCF5 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cevimeline + Sivelestat DCT7PFD Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Clascoterone + Sivelestat DCOTXWB Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Crotamiton + Sivelestat DC6UGOJ Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Cytarabine + Sivelestat DCLCV35 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Diazoxide + Sivelestat DCHP5L1 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Dichlorphenamide + Sivelestat DCT1N3X Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Doxorubicin + Sivelestat DCOT50J Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Estramustine + Sivelestat DCV86NI Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Fomepizole + Sivelestat DCUES6Y Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Galantamine + Sivelestat DCS8ROF Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Lefaxin + Sivelestat DC6C989 Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Levamisole + Sivelestat DCZQORU Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Linagliptin + Sivelestat DCXST1D Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Lubiprostone + Sivelestat DCQTSIT Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Lumefantrine + Sivelestat DC7CHDT Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Methotrexate + Sivelestat DC5ABBC Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Metyrosine + Sivelestat DC4WABJ Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Nitrosoglutathione + Sivelestat DCTPD8J Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Norcisapride + Sivelestat DCCMVWI Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Quinine + Sivelestat DCK2ID7 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Gefitinib DC29OBK Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Dantrolene DC0CRME Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Imipramine DC2OL4M Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Dactinomycin DC8TKU1 Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Epinephrine DCY2SMQ Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + PMID28460551-Compound-2 DCDK9V6 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Anamorelin DCPG6OH Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Methylergonovine DCFQN9W Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Carglumic acid DCZJXGD Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Pazopanib DCLBYGV Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Arfolitixorin DCQMBPP Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + BIO-300 DC18KFP BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + GINKGOLIDE A DCV0THM GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Darunavir DCQRKWD Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Bortezomib DCF2H9A Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Methylene blue DCUTD3K Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Maprotiline DCSWTV2 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Theophylline DCO3ISG Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Acarbose DCZ27UX Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Brincidofovir DCJRCI8 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Rufinamide DCBKS3D Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Cerivastatin DC3POQV Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Acetohydroxamic Acid DCRA0WB Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Tacrolimus DC5IDVD Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sivelestat + Tetracycline DCCLZHA Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Sumatriptan + Sivelestat DCC2YGG Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Topotecan + Sivelestat DC8P7R2 Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Trazodone + Sivelestat DC2TUR3 Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trimethobenzamide + Sivelestat DCFIM9B Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vinblastine + Sivelestat DCGRYR0 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Vorinostat + Sivelestat DC8VZKZ Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
------------------------------------------------------------------------------------
⏷ Show the Full List of 58 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.