Details of the Drug Combinations

General Information of This Drug (ID: DMBDAZV)

Drug Name
Amlodipine   DMBDAZV
Synonyms
Amlocard; Amlodipino; Amlodipinum; Amlodis; Amlopres; Amlor; Coroval; Intervask; Lipinox; AMLODIPINE BASE; Amlodipine Free Base; Amlodipino [Spanish]; Amlodipinum [Latin]; Racemic Amlodipine; Amlodipine (INN); Amlodipine [INN:BAN]; Dailyvasc (TN); Istin (TN); Norvasc (TN); Perivasc (TN); UK-4834011; R,S)-Amlodipine; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl); 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester; 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-Ethyl-5-methyl (+/-)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-Ethyl-5-methyl (-)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat; 3-Ethyl-5-methyl (-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Approved [1]
Chronic heart failure BD1Z Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Stroke 8B20 Investigative [1]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

39 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Aliskiren + Amlodipine DCI88F3 Aliskiren Hypertension With Metabolic Syndrome [3]
Aliskiren + Amlodipine DCNKDMM Aliskiren Hypertension [4]
Aliskiren + Amlodipine DC87PHA Aliskiren Hypertension [5]
Amlodipine + Amlodipine DC2QQ2G Amlodipine Hypertension [6]
Amlodipine + Telmisartan DC0IVRG Telmisartan Hypertension [6]
Amlodipine + Spironolactone DC3AZZ4 Spironolactone Hypertension [7]
Amlodipine + Ramipril DC4ONE7 Ramipril Hypertension With Metabolic Syndrome [3]
Amlodipine + Dobutamine DC4R3BG Dobutamine Heart Failure With Preserved Ejection Fraction [8]
Amlodipine + Valsartan DC55AFZ Valsartan Hypertension [9]
Amlodipine + Hydrochlorothiazide DCEPM00 Hydrochlorothiazide Hypertension [10]
Amlodipine + Indapamide DCKCLCZ Indapamide Hypertension [7]
Amlodipine + Valsartan DCYIBJG Valsartan Hypertension; Hypertrophy, Left Ventricular [11]
Amlodipine + Rosuvastatin DC547K2 Rosuvastatin Hypertension and Dyslipidemia [12]
Amlodipine + Rosuvastatin DC3GIF6 Rosuvastatin Hypertension [13]
Amlodipine + Raltegravir DC5GQF8 Raltegravir HIV [14]
Amlodipine + Candesartan DCN30A7 Candesartan Hypertension [15]
Chlorthalidone + Amlodipine DCPZY7H Chlorthalidone Hypertension [16]
Chlorthalidone + Amlodipine DCFUKT5 Chlorthalidone Hypertension [17]
Chlorthalidone + Amlodipine DC5AOCT Chlorthalidone Hypertension [18]
Deferasirox + Amlodipine DCO8L46 Deferasirox Beta-Thalassemia [19]
Diltiazem + Amlodipine DCISQOA Diltiazem Hepatitis C [20]
Irbesartan + Amlodipine DCWVKJV Irbesartan Hypertension [21]
Lisinopril + Amlodipine DCKEH45 Lisinopril Type 1 Diabetes [22]
Amlodipine + Olmesartan medoxomil DC6KPYL Olmesartan medoxomil Hypertension [23]
Amlodipine + Eplerenone DCN0SAO Eplerenone Hypertension [24]
Aliskiren + Amlodipine DC40W1W Aliskiren Hypertension [25]
Aliskiren + Amlodipine DCEQJAX Aliskiren Essential Hypertension [26]
Amlodipine + Ramipril DCF4LLD Ramipril Hypertension [27]
Amlodipine + Valsartan DCGCOKA Valsartan Hypertension [28]
Amlodipine + Atenolol DCT5GO7 Atenolol Cerebral Small Vessel Diseases [29]
Amlodipine + Losartan DCWO32W Losartan Hypertension [30]
Aliskiren + Amlodipine DCIVDAV Aliskiren Essential Hypertension ( Mild to Moderate) [31]
Amlodipine + Ramipril DCOOXCJ Ramipril Essential Hypertension [32]
Amlodipine + Ramipril DCCHOBT Ramipril Hypertension [33]
Amlodipine + Losartan DCIBFV5 Losartan Hypertension [34]
Amlodipine + Eplerenone DC6X9DN Eplerenone Metabolic Syndrome [35]
Amlodipine + MOXONIDINE DCI4OH0 MOXONIDINE Obesity [36]
Lisinopril + Amlodipine DCDVFOB Lisinopril Pediatric Hypertension [37]
Nebivolol + Amlodipine DC70WV4 Nebivolol Hypertension [38]
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⏷ Show the Full List of 39 DrugCom(s)

References

1 Amlodipine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6981).
3 ClinicalTrials.gov (NCT00542269) Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic Syndrome
4 ClinicalTrials.gov (NCT00402103) An Assessment of Long Term Safety of the Combination of Aliskiren / Amlodipine in Patients With High Blood Pressure
5 ClinicalTrials.gov (NCT00778921) Study to Evaluate the Efficacy and Safety of Combination Aliskiren/Amlodipine in Patients With Hypertension Not Adequately Responding to Amlodipine Alone
6 ClinicalTrials.gov (NCT00281580) Telmisartan (Micardis) and Amlodipine (Norvasc) - Factorial Design Study for the Treatment of Hypertension
7 ClinicalTrials.gov (NCT03626506) Spironolactone Versus Indapamide in Obese and Hypertensive Patients
8 ClinicalTrials.gov (NCT01354613) Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF)
9 ClinicalTrials.gov (NCT00523549) The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic Dysfunction
10 ClinicalTrials.gov (NCT00649389) Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension
11 ClinicalTrials.gov (NCT00446563) Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
12 ClinicalTrials.gov (NCT02933658) Study of Multiple Oral Dosing to Evaluate the Safety and the Pharmacokinetic Drug-drug Interaction of Telmisartan/Amlodipine and Rosuvastatin in Healthy Male Volunteers
13 ClinicalTrials.gov (NCT02789475) DP-R212 Pharmacokinetic Study
14 ClinicalTrials.gov (NCT01841593) A Two Way Cross Over Pharmacokinetic Interaction Study Between Raltegravir and Amlodipine in Healthy Volunteers
15 ClinicalTrials.gov (NCT02548286) Study to Compare the Safety and Pharmacokinetics of CKD-330 8/5mg With Coadministration of the Two Separate Drugs
16 ClinicalTrials.gov (NCT02121041) Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
17 ClinicalTrials.gov (NCT05976438) Skin Sodium and Salt Sensitivity of Blood Pressure
18 ClinicalTrials.gov (NCT02152969) Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
19 ClinicalTrials.gov (NCT02474420) Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
20 ClinicalTrials.gov (NCT01549496) A Drug Interaction Study of Boceprevir in Combination With Amlodipine or Diltiazem in Healthy Volunteers
21 I-COMBINE study: assessment of efficacy and safety profile of irbesartan/amlodipine fixed-dose combination therapy compared with amlodipine monotherapy in hypertensive patients uncontrolled with amlodipine 5 mg monotherapy: a multicenter, phase III, prospective, randomized, open-label with blinded-end point evaluation study. Clin Ther. 2012 Aug;34(8):1705-19.
22 ClinicalTrials.gov (NCT00337298) The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes
23 ClinicalTrials.gov (NCT01870739) A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension
24 ClinicalTrials.gov (NCT01996449) The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
25 ClinicalTrials.gov (NCT00797862) Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for Hypertension
26 ClinicalTrials.gov (NCT00667719) A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension
27 ClinicalTrials.gov (NCT00368277) A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the Elderly
28 ClinicalTrials.gov (NCT01365481) Safety and Tolerability of Valsartan in Children 6 to 17 Years of Age
29 ClinicalTrials.gov (NCT03082014) Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function
30 ClinicalTrials.gov (NCT04074551) A Phase 3 Study to Compare the Efficacy and Safety of Co-administered HGP0608, HGP0904 and HCP1306 Versus HCP1701 in Patients With Hypertension and Dyslipidemia
31 ClinicalTrials.gov (NCT00765947) Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate Hypertension
32 ClinicalTrials.gov (NCT01180413) Intensive Vasodilator Therapy in Patients With Essential Hypertension
33 ClinicalTrials.gov (NCT01922141) Aliskiren Study of Safety and Efficacy in Senior Hypertensives
34 ClinicalTrials.gov (NCT01176032) ALiskiren or Losartan Effects on bioMARKers of Myocardial Remodeling
35 ClinicalTrials.gov (NCT02034435) Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
36 ClinicalTrials.gov (NCT04474899) Sympathoinhibition as a Preferred Second Line Treatment of Obesity Related Hypertension
37 ClinicalTrials.gov (NCT03461003) N-of-1 Trials In Children With Hypertension
38 ClinicalTrials.gov (NCT05513937) Effectiveness and Safety of Combination of Nebivolol and Amlodipine in Hypertensive Patients Versus Each Monotherapy