Details of the Drug Combinations

General Information of This Drug (ID: DMBQYO0)

Drug Name

Casopitant DMBQYO0

Synonyms

Rezonic; Zunrisa; GW 679769; GW679769

Indication

Disease Entry	ICD 11	Status	REF
Chemotherapy-induced nausea	MD90	Withdrawn from market	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Casopitant + Rosiglitazone	DC15KI5	Rosiglitazone	Nausea and Vomiting, Chemotherapy-Induced	[2]
Casopitant + Dolasetron	DC3X2YD	Dolasetron	Nausea and Vomiting, Chemotherapy-Induced	[2]
Casopitant + Warfarin	DC68SUY	Warfarin	Nausea and Vomiting, Chemotherapy-Induced	[3]
Casopitant + Ketoconazole	DCAF1NV	Ketoconazole	Nausea and Vomiting, Chemotherapy-Induced	[4]
Casopitant + Casopitant	DC6FI90	Casopitant	Nausea and Vomiting, Chemotherapy-Induced	[5]
Dexamethasone + Casopitant	DC6EJC6	Dexamethasone	Cancer	[6]
Dexamethasone + Casopitant	DCH6Q4B	Dexamethasone	Nausea and Vomiting, Chemotherapy-Induced	[7]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5758).
2	ClinicalTrials.gov (NCT00511823) The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects
3	ClinicalTrials.gov (NCT00404274) A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers
4	ClinicalTrials.gov (NCT00404378) Study Of Healthy Subjects To Assess The Effect Of Ketoconazole And The Way The Body Will React To Casopitant [GW679769]
5	ClinicalTrials.gov (NCT00460707) A Study to Assess the Safety and Interaction Between Casopitant and Ketoconazole When Taken By Healthy Adults
6	ClinicalTrials.gov (NCT00891761) A Study of IV Casopitant for the Prevention of Nausea and Vomiting Caused By Cisplatin-Based Highly Emetogenic Chemotherapy
7	ClinicalTrials.gov (NCT00601172) A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting.