Details of the Drug Combinations

General Information of This Drug (ID: DMCUT21)

• Drug Name: Ursodeoxycholic acid (DMCUT21)
• Synonyms: Actigall; Antigall; Arsacol; Delursan; Destolit; Deursil; Litursol; Lyeton; Peptarom; Solutrat; UDCA; UDCS; UrSO; Urosiol; Ursacol; Ursobilin; Ursochol; Ursodamor; Ursodeoxycholate; Ursodiol; Ursofalk; Ursolvan; Ursosan; Acide ursodesoxycholique; Acido ursodeossicolico; Acido ursodeossicolico [Italian]; Acido ursodeoxicolico; Acidum ursodeoxycholicum; Deoxyursocholic Acid; Sodium Ursodeoxycholate; Ursacholic Acid; Urso DS; Urso Forte; Ursodeoxy cholic acid; Ursodesoxycholicacid; Ursodexycholic Acid; Ursodiol [USAN]; IU5; U0030; Urso 250; Acide ursodesoxycholique [INN-French]; Acido ursodeoxicolico [INN-Spanish]; Acidum ursodeoxycholicum [INN-Latin]; Actigall (TN); Cholit-ursan; Deursil (TN); Dom-ursodiol c; ISO-URSODEOXYCHOLIC ACID; PHL-ursodiol c; PMS-ursodiol c; U-9000; Urso (TN); Urso Forte (TN); Ursodiol (USP); Ursosan (TN); Ursodeoxycholic acid (JP15/INN); Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol; Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)-(9CI); (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid; (3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; 3,7-Dihydroxycholan-24-oic acid; 3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid; 3-alpha,7-beta-Dihydroxycholanic acid; 3-alpha,7-beta-Dioxycholanic acid; 3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid; 3alpha,7beta-Dihydroxy-5beta-cholanic acid; 5beta-Cholan-24-oic acid-3alpha,7beta-diol; 5beta-Cholanic Acid-3alpha,7beta-diol; 7-beta-Hydroxylithocholic acid; 7beta-Hydroxylithocholic acid

Indication

Cholelithiasis; ICD 11: DC11; Status: Approved [1]; Primary biliary cholangitis; ICD 11: DB96.1; Status: Approved [2]; Primary biliary cirrhosis; ICD 11: DB96.1; Status: Approved [3]; Colon cancer; ICD 11: 2B90.Z; Status: Investigative [4]

• Therapeutic Class: Cholagogues and Choleretics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Ursodeoxycholic acid	DCQ1BCU	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Albendazole + Ursodeoxycholic acid	DCQ3CRD	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Arfolitixorin + Ursodeoxycholic acid	DCZXNSN	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Artemisinin + Ursodeoxycholic acid	DCX4MB8	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
BIO-300 + Ursodeoxycholic acid	DC6JD46	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bortezomib + Ursodeoxycholic acid	DC7JYHL	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Brincidofovir + Ursodeoxycholic acid	DCX8GCK	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cerivastatin + Ursodeoxycholic acid	DCLBQAO	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chlorzoxazone + Ursodeoxycholic acid	DC8RN0K	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Docetaxel + Ursodeoxycholic acid	DCDHBSR	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Epinephrine + Ursodeoxycholic acid	DCW0V6A	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Idarubicin + Ursodeoxycholic acid	DCWOVCF	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Iloprost + Ursodeoxycholic acid	DCSXMCG	Iloprost	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Imatinib + Ursodeoxycholic acid	DCRH5IK	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Isoproterenol + Ursodeoxycholic acid	DCKAKJF	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Ursodeoxycholic acid	DC72NC8	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Levamisole + Ursodeoxycholic acid	DC5LFY2	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Maprotiline + Ursodeoxycholic acid	DCL3V18	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Memantine + Ursodeoxycholic acid	DC78Y5P	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Naringenin + Ursodeoxycholic acid	DCUWO91	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pazopanib + Ursodeoxycholic acid	DC81M9X	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
PMID28460551-Compound-2 + Ursodeoxycholic acid	DC8EI2V	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pramipexole + Ursodeoxycholic acid	DCEND54	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Testosterone cypionate + Ursodeoxycholic acid	DCID30I	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trihexyphenidyl + Ursodeoxycholic acid	DC1UZMZ	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Gefitinib	DCBPKHZ	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Diethylcarbamazine	DCWKLLZ	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Lumefantrine	DCEULKA	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Kanamycin	DC227KQ	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Pazopanib HCl	DCFC229	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Terameprocol	DCWKT97	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Itraconazole	DCR5LSF	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Phensuximide	DC2719Q	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Armodafinil	DCKCGT1	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + PF-02545920	DC9H63S	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Trazodone	DCZTCGY	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Tiagabine	DCJL6BP	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Oseltamivir	DCGQ3GO	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Diazoxide	DCQS0NJ	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Idarubicin	DCKWE65	Idarubicin	Glioblastoma? (Cell Line: T98G)	[5]
Ursodeoxycholic acid + BRL-15572	DCX3EP1	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Darunavir	DCQREJA	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Mebendazole	DC3M7BY	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Dopamine	DCDUMPE	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Trimethobenzamide	DCM114N	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Enalaprilat	DCU4MUI	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Asenapine	DCIW2TM	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Quinine	DCIE3ZE	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Endoxifen	DCW4ST6	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Mefloquine	DCL8YZQ	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Zileuton	DC3COQ4	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + FORMESTANE	DCJDRIP	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Cerivastatin	DCB7PEN	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Cytarabine	DCD0J68	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Etomidate	DC0HJQY	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + L-165041	DCL1BJ6	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Valproic Acid + Ursodeoxycholic acid	DCC0TWQ	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Celecoxib + Ursodeoxycholic acid	DCTG6Z6	Celecoxib	Familial Adenomatous Polyposis	[6]
Obeticholic acid + Ursodeoxycholic acid	DCDR1RC	Obeticholic acid	PBC	[7]
Doxycycline + Ursodeoxycholic acid	DCWFJV6	Doxycycline	Transthyretin Amyloidosis	[8]
Heparin + Ursodeoxycholic acid	DCKWF9C	Heparin	Colorectal Cancer	[9]
Obeticholic acid + Ursodeoxycholic acid	DCWET3R	Obeticholic acid	Primary Biliary Cirrhosis	[10]
Ursodeoxycholic acid + Bezafibrate	DC2URLI	Bezafibrate	Primary Biliary Cirrhosis	[11]
Ursodeoxycholic acid + Fenofibrate	DC2ZSFY	Fenofibrate	Primary Biliary Cirrhosis	[12]
Ursodeoxycholic acid + Metformin	DCGUFOE	Metformin	Diabetes Mellitus, Type 2	[13]

References

• [1] Management of symptomatic cholelithiasis: a systematic review. Syst Rev. 2022 Dec 12;11(1):267.
• [2] Primary biliary cholangitis: pathogenesis and therapeutic opportunities. Nat Rev Gastroenterol Hepatol. 2020 Feb;17(2):93-110.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7104).
• [4] Design and synthesis of bile acid derivatives and their activity against colon cancer. RSC Med Chem. 2022 Aug 19;13(11):1391-1409.
• [5] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [6] ClinicalTrials.gov (NCT00808743) Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis
• [7] ClinicalTrials.gov (NCT04076527) Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis
• [8] ClinicalTrials.gov (NCT02016365) Safety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis
• [9] ClinicalTrials.gov (NCT01149304) Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity
• [10] ClinicalTrials.gov (NCT04956328) Study of Obeticholic AcidOCA?Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC)
• [11] ClinicalTrials.gov (NCT04751188) A Study to Assess Efficacy and Safety of Bezafibrate in Patients With Primary Biliary Cholangitis
• [12] ClinicalTrials.gov (NCT02823366) Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid
• [13] ClinicalTrials.gov (NCT05416580) Efficacy of Ursodeoxycholic Acid (UDCA) in Patients With Type 2 Diabetes