Details of the Drug Combinations

General Information of This Drug (ID: DMCUT21)

Drug Name

Ursodeoxycholic acid DMCUT21

Synonyms

Actigall; Antigall; Arsacol; Delursan; Destolit; Deursil; Litursol; Lyeton; Peptarom; Solutrat; UDCA; UDCS; UrSO; Urosiol; Ursacol; Ursobilin; Ursochol; Ursodamor; Ursodeoxycholate; Ursodiol; Ursofalk; Ursolvan; Ursosan; Acide ursodesoxycholique; Acido ursodeossicolico; Acido ursodeossicolico [Italian]; Acido ursodeoxicolico; Acidum ursodeoxycholicum; Deoxyursocholic Acid; Sodium Ursodeoxycholate; Ursacholic Acid; Urso DS; Urso Forte; Ursodeoxy cholic acid; Ursodesoxycholicacid; Ursodexycholic Acid; Ursodiol [USAN]; IU5; U0030; Urso 250; Acide ursodesoxycholique [INN-French]; Acido ursodeoxicolico [INN-Spanish]; Acidum ursodeoxycholicum [INN-Latin]; Actigall (TN); Cholit-ursan; Deursil (TN); Dom-ursodiol c; ISO-URSODEOXYCHOLIC ACID; PHL-ursodiol c; PMS-ursodiol c; U-9000; Urso (TN); Urso Forte (TN); Ursodiol (USP); Ursosan (TN); Ursodeoxycholic acid (JP15/INN); Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol; Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)-(9CI); (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid; (3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; 3,7-Dihydroxycholan-24-oic acid; 3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid; 3-alpha,7-beta-Dihydroxycholanic acid; 3-alpha,7-beta-Dioxycholanic acid; 3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid; 3alpha,7beta-Dihydroxy-5beta-cholanic acid; 5beta-Cholan-24-oic acid-3alpha,7beta-diol; 5beta-Cholanic Acid-3alpha,7beta-diol; 7-beta-Hydroxylithocholic acid; 7beta-Hydroxylithocholic acid

Indication

Disease Entry	ICD 11	Status	REF
Cholelithiasis	DC11	Approved	[1]
Primary biliary cholangitis	DB96.1	Approved	[2]
Primary biliary cirrhosis	DB96.1	Approved	[3]
Colon cancer	2B90.Z	Investigative	[4]
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Therapeutic Class

Cholagogues and Choleretics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Ursodeoxycholic acid	DCQ1BCU	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Albendazole + Ursodeoxycholic acid	DCQ3CRD	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Arfolitixorin + Ursodeoxycholic acid	DCZXNSN	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Artemisinin + Ursodeoxycholic acid	DCX4MB8	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
BIO-300 + Ursodeoxycholic acid	DC6JD46	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bortezomib + Ursodeoxycholic acid	DC7JYHL	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Brincidofovir + Ursodeoxycholic acid	DCX8GCK	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cerivastatin + Ursodeoxycholic acid	DCLBQAO	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chlorzoxazone + Ursodeoxycholic acid	DC8RN0K	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Docetaxel + Ursodeoxycholic acid	DCDHBSR	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Epinephrine + Ursodeoxycholic acid	DCW0V6A	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Idarubicin + Ursodeoxycholic acid	DCWOVCF	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Iloprost + Ursodeoxycholic acid	DCSXMCG	Iloprost	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Imatinib + Ursodeoxycholic acid	DCRH5IK	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Isoproterenol + Ursodeoxycholic acid	DCKAKJF	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Ursodeoxycholic acid	DC72NC8	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Levamisole + Ursodeoxycholic acid	DC5LFY2	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Maprotiline + Ursodeoxycholic acid	DCL3V18	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Memantine + Ursodeoxycholic acid	DC78Y5P	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Naringenin + Ursodeoxycholic acid	DCUWO91	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pazopanib + Ursodeoxycholic acid	DC81M9X	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
PMID28460551-Compound-2 + Ursodeoxycholic acid	DC8EI2V	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pramipexole + Ursodeoxycholic acid	DCEND54	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Testosterone cypionate + Ursodeoxycholic acid	DCID30I	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trihexyphenidyl + Ursodeoxycholic acid	DC1UZMZ	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Gefitinib	DCBPKHZ	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Diethylcarbamazine	DCWKLLZ	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Lumefantrine	DCEULKA	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Kanamycin	DC227KQ	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Pazopanib HCl	DCFC229	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Terameprocol	DCWKT97	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Itraconazole	DCR5LSF	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Phensuximide	DC2719Q	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Armodafinil	DCKCGT1	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + PF-02545920	DC9H63S	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Trazodone	DCZTCGY	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Tiagabine	DCJL6BP	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Oseltamivir	DCGQ3GO	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Diazoxide	DCQS0NJ	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Idarubicin	DCKWE65	Idarubicin	Glioblastoma? (Cell Line: T98G)	[5]
Ursodeoxycholic acid + BRL-15572	DCX3EP1	BRL-15572	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Darunavir	DCQREJA	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Mebendazole	DC3M7BY	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Dopamine	DCDUMPE	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Trimethobenzamide	DCM114N	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Enalaprilat	DCU4MUI	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Asenapine	DCIW2TM	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Quinine	DCIE3ZE	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Endoxifen	DCW4ST6	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Mefloquine	DCL8YZQ	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Zileuton	DC3COQ4	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + FORMESTANE	DCJDRIP	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Cerivastatin	DCB7PEN	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Cytarabine	DCD0J68	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + Etomidate	DC0HJQY	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ursodeoxycholic acid + L-165041	DCL1BJ6	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Valproic Acid + Ursodeoxycholic acid	DCC0TWQ	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
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⏷ Show the Full List of 57 DrugCom(s)

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Celecoxib + Ursodeoxycholic acid	DCTG6Z6	Celecoxib	Familial Adenomatous Polyposis	[6]
Obeticholic acid + Ursodeoxycholic acid	DCDR1RC	Obeticholic acid	PBC	[7]
Doxycycline + Ursodeoxycholic acid	DCWFJV6	Doxycycline	Transthyretin Amyloidosis	[8]
Heparin + Ursodeoxycholic acid	DCKWF9C	Heparin	Colorectal Cancer	[9]
Obeticholic acid + Ursodeoxycholic acid	DCWET3R	Obeticholic acid	Primary Biliary Cirrhosis	[10]
Ursodeoxycholic acid + Bezafibrate	DC2URLI	Bezafibrate	Primary Biliary Cirrhosis	[11]
Ursodeoxycholic acid + Fenofibrate	DC2ZSFY	Fenofibrate	Primary Biliary Cirrhosis	[12]
Ursodeoxycholic acid + Metformin	DCGUFOE	Metformin	Diabetes Mellitus, Type 2	[13]
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⏷ Show the Full List of 8 DrugCom(s)

References

1	Management of symptomatic cholelithiasis: a systematic review. Syst Rev. 2022 Dec 12;11(1):267.
2	Primary biliary cholangitis: pathogenesis and therapeutic opportunities. Nat Rev Gastroenterol Hepatol. 2020 Feb;17(2):93-110.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7104).
4	Design and synthesis of bile acid derivatives and their activity against colon cancer. RSC Med Chem. 2022 Aug 19;13(11):1391-1409.
5	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6	ClinicalTrials.gov (NCT00808743) Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis
7	ClinicalTrials.gov (NCT04076527) Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis
8	ClinicalTrials.gov (NCT02016365) Safety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis
9	ClinicalTrials.gov (NCT01149304) Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity
10	ClinicalTrials.gov (NCT04956328) Study of Obeticholic AcidOCA?Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC)
11	ClinicalTrials.gov (NCT04751188) A Study to Assess Efficacy and Safety of Bezafibrate in Patients With Primary Biliary Cholangitis
12	ClinicalTrials.gov (NCT02823366) Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid
13	ClinicalTrials.gov (NCT05416580) Efficacy of Ursodeoxycholic Acid (UDCA) in Patients With Type 2 Diabetes