Details of the Drug Combination

General Information of Drug Combination (ID: DCWET3R)

• Drug Combination Name: obeticholic acid + Ursodeoxycholic acid
• Indication: Primary Biliary Cirrhosis; Status: Phase 3 [1]
• Component Drugs:
  obeticholic acid (DM3Q1SM): Small molecular drug
  Ursodeoxycholic acid (DMCUT21): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of obeticholic acid

Disease Entry	ICD 11	Status	REF
Primary biliary cholangitis	DB96.1	Approved	[2]
Insomnia	7A00-7A0Z	Clinical trial	[3]

obeticholic acid Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Farnesoid X-activated receptor (FXR)	TTS4UGC	NR1H4_HUMAN	Modulator	[2]

obeticholic acid Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Bile acid-CoA thioesterase (BAAT)	DERA3OF	BAAT_HUMAN	Metabolism	[10]

obeticholic acid Interacts with 160 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Very long chain fatty acid elongase 7 (ELOVL7)	OT89NYVC	ELOV7_HUMAN	Increases Expression	[8]
cTAGE family member 15 (CTAGE15)	OTMOMQGH	CTGEF_HUMAN	Increases Expression	[8]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)	OTOMP6TH	PK3CD_HUMAN	Decreases Expression	[8]
Nuclear receptor subfamily 5 group A member 2 (NR5A2)	OTXAUJAS	NR5A2_HUMAN	Decreases Expression	[8]
Suppressor of cytokine signaling 2 (SOCS2)	OTBPNKJQ	SOCS2_HUMAN	Decreases Expression	[8]
Copper chaperone for superoxide dismutase (CCS)	OTXHT3QO	CCS_HUMAN	Decreases Expression	[8]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Increases Expression	[8]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)	OT1Q40TZ	MP2K7_HUMAN	Decreases Expression	[8]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Decreases Expression	[8]
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3)	OTZEPVGF	ACOX3_HUMAN	Increases Expression	[8]
Tapasin (TAPBP)	OTL81AVZ	TPSN_HUMAN	Decreases Expression	[8]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Decreases Expression	[8]
Long-chain-fatty-acid--CoA ligase 4 (ACSL4)	OTI71MUJ	ACSL4_HUMAN	Increases Expression	[8]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Increases Expression	[8]
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)	OTTK8MUO	KS6A4_HUMAN	Decreases Expression	[8]
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)	OTB4YBVT	S2512_HUMAN	Decreases Expression	[8]
Lathosterol oxidase (SC5D)	OT41KMW4	SC5D_HUMAN	Decreases Expression	[8]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Decreases Expression	[8]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Decreases Expression	[8]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Decreases Expression	[8]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Decreases Expression	[8]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Decreases Expression	[8]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[8]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Expression	[8]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[8]
Apolipoprotein C-II (APOC2)	OTLINYIQ	APOC2_HUMAN	Increases Expression	[8]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Decreases Expression	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Decreases Expression	[8]
Fructose-bisphosphate aldolase A (ALDOA)	OTWRFTIB	ALDOA_HUMAN	Decreases Expression	[8]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Decreases Expression	[8]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[8]
Fructose-bisphosphate aldolase B (ALDOB)	OT7FR69A	ALDOB_HUMAN	Decreases Expression	[8]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Decreases Expression	[8]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[8]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Decreases Expression	[8]
Histone H2B type 1-J (H2BC11)	OTGM083T	H2B1J_HUMAN	Decreases Expression	[8]
Protein disulfide-isomerase (P4HB)	OTTYNYPF	PDIA1_HUMAN	Increases Expression	[8]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Decreases Expression	[8]
Proto-oncogene tyrosine-protein kinase ROS (ROS1)	OTDSKUGE	ROS1_HUMAN	Increases Expression	[8]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)	OTVKRET0	THIK_HUMAN	Increases Expression	[8]
Inhibin beta B chain (INHBB)	OT2QLD11	INHBB_HUMAN	Increases Expression	[8]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Increases Expression	[8]
Transforming growth factor beta-3 proprotein (TGFB3)	OT2LOUQ1	TGFB3_HUMAN	Increases Expression	[8]
Hepatic triacylglycerol lipase (LIPC)	OTZY5SC9	LIPC_HUMAN	Decreases Expression	[8]
Pyruvate carboxylase, mitochondrial (PC)	OT6O0V51	PYC_HUMAN	Decreases Expression	[8]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Increases Expression	[8]
Farnesyl pyrophosphate synthase (FDPS)	OT6CKWV5	FPPS_HUMAN	Decreases Expression	[8]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (PFKFB1)	OTTHX4NB	F261_HUMAN	Increases Expression	[8]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Decreases Expression	[8]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Decreases Expression	[8]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[8]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Increases Expression	[8]
Phosphatidylcholine translocator ABCB4 (ABCB4)	OTE6PY83	MDR3_HUMAN	Increases Expression	[8]
Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)	OTQW7TMB	GPDA_HUMAN	Decreases Expression	[8]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[8]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)	OTIN6G20	CPT2_HUMAN	Increases Expression	[8]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Decreases Expression	[8]
Peroxiredoxin-6 (PRDX6)	OTS8KC8A	PRDX6_HUMAN	Decreases Expression	[8]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)	OTFIHQGD	2AAB_HUMAN	Increases Expression	[8]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Decreases Expression	[8]
Glycerol kinase (GK)	OTK2YRA0	GLPK_HUMAN	Decreases Expression	[8]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Decreases Expression	[8]
Protein S100-A3 (S100A3)	OTVIZJ2R	S10A3_HUMAN	Decreases Expression	[8]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Decreases Expression	[8]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)	OTTWCZYM	ALS_HUMAN	Decreases Expression	[8]
Interleukin-6 receptor subunit beta (IL6ST)	OT1N9C70	IL6RB_HUMAN	Decreases Expression	[8]
Malate dehydrogenase, cytoplasmic (MDH1)	OTJEO4E8	MDHC_HUMAN	Increases Expression	[8]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)	OTOZTA1F	M3K8_HUMAN	Increases Expression	[8]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Decreases Expression	[8]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Increases Expression	[8]
Aldo-keto reductase family 1 member D1 (AKR1D1)	OTBDJ6RL	AK1D1_HUMAN	Decreases Expression	[8]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Decreases Expression	[8]
Tricarboxylate transport protein, mitochondrial (SLC25A1)	OTIDXQ9F	TXTP_HUMAN	Decreases Expression	[8]
Mitogen-activated protein kinase 12 (MAPK12)	OTTCKE27	MK12_HUMAN	Decreases Expression	[8]
Glycogen synthase, liver (GYS2)	OTCKIUYR	GYS2_HUMAN	Increases Expression	[8]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Expression	[8]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Decreases Expression	[8]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Decreases Expression	[8]
Ras-related protein R-Ras2 (RRAS2)	OT83NCEB	RRAS2_HUMAN	Increases Expression	[8]
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)	OT24GMCM	PP2AB_HUMAN	Increases Expression	[8]
Metallothionein-1H (MT1H)	OT0MVBM6	MT1H_HUMAN	Decreases Expression	[8]
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2)	OT6HTSJT	PGBM_HUMAN	Decreases Expression	[8]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Decreases Expression	[8]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Decreases Expression	[8]
Sterol 26-hydroxylase, mitochondrial (CYP27A1)	OT649C01	CP27A_HUMAN	Decreases Expression	[8]
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Increases Expression	[8]
Peroxiredoxin-1 (PRDX1)	OTZ3BEC4	PRDX1_HUMAN	Decreases Expression	[8]
Cytochrome P450 4F3 (CYP4F3)	OTYNSQAM	CP4F3_HUMAN	Decreases Expression	[8]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Decreases Expression	[8]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Decreases Expression	[8]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Increases Expression	[8]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Decreases Expression	[8]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Increases Expression	[8]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[8]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Decreases Expression	[8]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Decreases Expression	[8]
Delta(14)-sterol reductase LBR (LBR)	OT1HG3HG	LBR_HUMAN	Decreases Expression	[8]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)	OTM0A0DY	ACOX1_HUMAN	Increases Expression	[8]
Transcription elongation factor A protein 2 (TCEA2)	OT1OS9TY	TCEA2_HUMAN	Increases Expression	[8]
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1)	OTPM6F85	TAB1_HUMAN	Decreases Expression	[8]
Mitogen-activated protein kinase 11 (MAPK11)	OT0AS010	MK11_HUMAN	Decreases Expression	[8]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Increases Expression	[8]
Meteorin-like protein (METRNL)	OTB0DDL0	METRL_HUMAN	Decreases Expression	[8]
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3)	OTDMU3GP	CR3L3_HUMAN	Increases Expression	[8]
Single Ig IL-1-related receptor (SIGIRR)	OTNC3XFD	SIGIR_HUMAN	Decreases Expression	[8]
Ultra-long-chain fatty acid omega-hydroxylase (CYP4F22)	OTMNPZQL	CP4FN_HUMAN	Decreases Expression	[8]
SUZ domain-containing protein 1 (SZRD1)	OTJMEJWT	SZRD1_HUMAN	Increases Expression	[8]
Cytochrome P450 2U1 (CYP2U1)	OT6RXLXS	CP2U1_HUMAN	Increases Expression	[8]
Tubulin epsilon and delta complex protein 1 (TEDC1)	OT2RIGR7	TEDC1_HUMAN	Decreases Expression	[8]
ADAMTS-like protein 2 (ADAMTSL2)	OTAXNV2U	ATL2_HUMAN	Decreases Expression	[8]
60 kDa lysophospholipase (ASPG)	OT5E2EKR	LPP60_HUMAN	Decreases Expression	[8]
Organic solute transporter subunit alpha (SLC51A)	OTDJRZ0P	OSTA_HUMAN	Increases Expression	[8]
Organic solute transporter subunit beta (SLC51B)	OT4WYPSR	OSTB_HUMAN	Increases Expression	[8]
Na(+)/citrate cotransporter (SLC13A5)	OTPH1TA7	S13A5_HUMAN	Decreases Expression	[8]
Leucine-rich repeat LGI family member 4 (LGI4)	OTZGS8BN	LGI4_HUMAN	Increases Expression	[8]
Neuropeptide W (NPW)	OTO7MT28	NPW_HUMAN	Decreases Expression	[8]
Sodium-dependent lysophosphatidylcholine symporter 1 (MFSD2A)	OTVG1VG0	NLS1_HUMAN	Increases Expression	[8]
Mixed lineage kinase domain-like protein (MLKL)	OTDSLC81	MLKL_HUMAN	Decreases Expression	[8]
Phosphatidate phosphatase LPIN2 (LPIN2)	OTRRTMXX	LPIN2_HUMAN	Decreases Expression	[8]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Decreases Expression	[8]
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1)	OT2JHIHM	CR3L1_HUMAN	Decreases Expression	[8]
Leukocyte receptor cluster member 8 (LENG8)	OT6B5K2T	LENG8_HUMAN	Increases Expression	[8]
Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)	OT3VH359	ACOX2_HUMAN	Increases Expression	[8]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)	OTT3DOOL	M3K14_HUMAN	Decreases Expression	[8]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Decreases Expression	[8]
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT)	OTJX1YC7	ECSIT_HUMAN	Decreases Expression	[8]
Receptor-transporting protein 3 (RTP3)	OTZUDJ6Q	RTP3_HUMAN	Increases Expression	[8]
Very long chain fatty acid elongase 1 (ELOVL1)	OTIDTQ8R	ELOV1_HUMAN	Increases Expression	[8]
Protein amnionless (AMN)	OTS1TJXG	AMNLS_HUMAN	Decreases Expression	[8]
Forkhead box protein P3 (FOXP3)	OTA9Z9OC	FOXP3_HUMAN	Increases Expression	[8]
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7)	OT2Y9IW4	3BHS7_HUMAN	Decreases Expression	[8]
Lck-interacting transmembrane adapter 1 (LIME1)	OTJWUQSK	LIME1_HUMAN	Decreases Expression	[8]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Decreases Expression	[8]
Cytochrome P450 4F11 (CYP4F11)	OTHZ2GG2	CP4FB_HUMAN	Decreases Expression	[8]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)	OTR1XD9B	GPAT1_HUMAN	Decreases Expression	[8]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3)	OTOM3BUH	SO1B3_HUMAN	Increases Expression	[8]
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)	OTNY3VMD	PLCE_HUMAN	Decreases Expression	[8]
Very long chain fatty acid elongase 2 (ELOVL2)	OTDAF6U3	ELOV2_HUMAN	Increases Expression	[8]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)	OTBAJT4I	CP39A_HUMAN	Decreases Expression	[8]
Very-long-chain enoyl-CoA reductase (TECR)	OT2NT4MV	TECR_HUMAN	Decreases Expression	[8]
C5a anaphylatoxin chemotactic receptor 2 (C5AR2)	OTP1Q82J	C5AR2_HUMAN	Decreases Expression	[8]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Increases Expression	[8]
DnaJ homolog subfamily B member 11 (DNAJB11)	OTDDK2SY	DJB11_HUMAN	Increases Expression	[8]
Mitochondrial dicarboxylate carrier (SLC25A10)	OTT8647H	DIC_HUMAN	Decreases Expression	[8]
Cysteine-rich C-terminal protein 1 (CRCT1)	OTPYME8V	CRCT1_HUMAN	Decreases Expression	[8]
Fetuin-B (FETUB)	OT7V07NI	FETUB_HUMAN	Increases Expression	[8]
Polypyrimidine tract-binding protein 2 (PTBP2)	OTF4S7NE	PTBP2_HUMAN	Decreases Expression	[8]
Long-chain-fatty-acid--CoA ligase 6 (ACSL6)	OT0TT8P8	ACSL6_HUMAN	Increases Expression	[8]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5)	OT3L9XO3	ACSL5_HUMAN	Increases Expression	[8]
Myocardin-related transcription factor B (MRTFB)	OT9OXGS9	MRTFB_HUMAN	Decreases Expression	[8]
Carbonic anhydrase 14 (CA14)	OT1TRKFN	CAH14_HUMAN	Increases Expression	[8]
Transcription factor MafF (MAFF)	OT9B7MX0	MAFF_HUMAN	Increases Expression	[8]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Increases Expression	[8]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Decreases Expression	[8]
Long-chain fatty acid transport protein 5 (SLC27A5)	OT4OK511	S27A5_HUMAN	Decreases Expression	[8]
Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)	OTBOQE6N	ACOT9_HUMAN	Increases Expression	[8]
Chloride intracellular channel protein 4 (CLIC4)	OT6KTPKD	CLIC4_HUMAN	Increases Expression	[8]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Decreases Expression	[8]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Increases Expression	[11]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Increases Expression	[11]

Indication(s) of Ursodeoxycholic acid

Disease Entry	ICD 11	Status	REF
Cholelithiasis	DC11	Approved	[4]
Primary biliary cholangitis	DB96.1	Approved	[5]
Primary biliary cirrhosis	DB96.1	Approved	[6]
Colon cancer	2B90.Z	Investigative	[7]

Ursodeoxycholic acid Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Solute carrier family 23 member 2 (SLC23A2)	TTOP832	S23A2_HUMAN	Activator	[13]
Biliverdin reductase A (BLVRA)	TTJBPN3	BIEA_HUMAN	Activator	[13]

Ursodeoxycholic acid Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[14]

Ursodeoxycholic acid Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Beta-hydroxysteroid dehydrogenase (hdhB)	DEOMLHG	A4ECA9_9ACTN	Metabolism	[15]

Ursodeoxycholic acid Interacts with 69 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Increases Uptake	[14]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Decreases Activity	[16]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Decreases Activity	[16]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Decreases Activity	[16]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[17]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[18]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Increases Expression	[18]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Decreases Expression	[19]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[20]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)	OTRBREQ9	ANR28_HUMAN	Affects Expression	[12]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[21]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Increases Expression	[22]
Splicing factor 3B subunit 1 (SF3B1)	OTNTX2DG	SF3B1_HUMAN	Affects Expression	[12]
Rho-related BTB domain-containing protein 3 (RHOBTB3)	OT1BFKPH	RHBT3_HUMAN	Affects Expression	[12]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Increases Expression	[23]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)	OT7KZMP2	DRA_HUMAN	Increases Expression	[24]
Fibrinogen gamma chain (FGG)	OT5BJSEX	FIBG_HUMAN	Affects Expression	[12]
C4b-binding protein alpha chain (C4BPA)	OTHNH6Y8	C4BPA_HUMAN	Affects Expression	[12]
ADP/ATP translocase 2 (SLC25A5)	OT1XIBMN	ADT2_HUMAN	Affects Expression	[12]
Large ribosomal subunit protein P2 (RPLP2)	OT2YBK3W	RLA2_HUMAN	Affects Expression	[12]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Expression	[25]
Involucrin (IVL)	OT4VPNGY	INVO_HUMAN	Decreases Expression	[26]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[19]
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)	OTB8HCED	CN37_HUMAN	Affects Expression	[12]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[20]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)	OT9LBJVN	ODP2_HUMAN	Affects Expression	[12]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[19]
Fatty acid-binding protein, adipocyte (FABP4)	OT3DKFOU	FABP4_HUMAN	Decreases Expression	[19]
Large ribosomal subunit protein eL33 (RPL35A)	OTDDJUWF	RL35A_HUMAN	Affects Expression	[12]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Decreases Expression	[19]
Alpha-1-acid glycoprotein 2 (ORM2)	OTRJGZP8	A1AG2_HUMAN	Affects Expression	[12]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[19]
Large ribosomal subunit protein uL16 (RPL10)	OTBHOZGC	RL10_HUMAN	Affects Expression	[12]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[19]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[25]
Intercellular adhesion molecule 3 (ICAM3)	OTTZ5A5D	ICAM3_HUMAN	Affects Expression	[12]
Glycine--tRNA ligase (GARS1)	OT5B6R9Y	GARS_HUMAN	Affects Expression	[12]
Eukaryotic translation initiation factor 1 (EIF1)	OTB4GZ0V	EIF1_HUMAN	Affects Expression	[12]
T-complex protein 1 subunit epsilon (CCT5)	OTPZ38BT	TCPE_HUMAN	Affects Expression	[12]
T-complex protein 1 subunit gamma (CCT3)	OTL6EOS1	TCPG_HUMAN	Affects Expression	[12]
Gastrotropin (FABP6)	OTIRQWLW	FABP6_HUMAN	Increases Expression	[27]
Small ribosomal subunit protein mS29 (DAP3)	OTNPEZYM	RT29_HUMAN	Affects Expression	[12]
Nucleosome assembly protein 1-like 1 (NAP1L1)	OTI7WBZV	NP1L1_HUMAN	Affects Expression	[12]
Large ribosomal subunit protein eL27 (RPL27)	OTWEOUTX	RL27_HUMAN	Affects Expression	[12]
Small ribosomal subunit protein uS15 (RPS13)	OTOMDIJ2	RS13_HUMAN	Affects Expression	[12]
Small ribosomal subunit protein eS28 (RPS28)	OT12IES1	RS28_HUMAN	Affects Expression	[12]
Large ribosomal subunit protein eL32 (RPL32)	OTKRQJT4	RL32_HUMAN	Affects Expression	[12]
Large ribosomal subunit protein eL6 (RPL6)	OTRU71O4	RL6_HUMAN	Affects Expression	[12]
Single-stranded DNA-binding protein, mitochondrial (SSBP1)	OTH2PZWH	SSBP_HUMAN	Affects Expression	[12]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Affects Expression	[12]
Fibrinogen-like protein 1 (FGL1)	OTT0QHQ1	FGL1_HUMAN	Affects Expression	[12]
Serine/threonine-protein kinase 3 (STK3)	OTLNSCQD	STK3_HUMAN	Affects Expression	[12]
DnaJ homolog subfamily C member 3 (DNAJC3)	OT7ROIJF	DNJC3_HUMAN	Decreases Expression	[19]
Protein Smaug homolog 2 (SAMD4B)	OTVRZJ5D	SMAG2_HUMAN	Affects Expression	[12]
Ribosomal protein eS27-like (RPS27L)	OTZWHU0N	RS27L_HUMAN	Affects Expression	[12]
Endoplasmic reticulum metallopeptidase 1 (ERMP1)	OT9CIEO2	ERMP1_HUMAN	Affects Expression	[12]
E3 ubiquitin-protein ligase RBBP6 (RBBP6)	OTTVG4HU	RBBP6_HUMAN	Affects Expression	[12]
Out at first protein homolog (OAF)	OTOR9CR5	OAF_HUMAN	Affects Expression	[12]
Organic solute transporter subunit alpha (SLC51A)	OTDJRZ0P	OSTA_HUMAN	Increases Expression	[21]
Organic solute transporter subunit beta (SLC51B)	OT4WYPSR	OSTB_HUMAN	Increases Expression	[21]
Shieldin complex subunit 2 (SHLD2)	OTMLERXL	SHLD2_HUMAN	Affects Expression	[12]
E3 ubiquitin-protein ligase rififylin (RFFL)	OT85MGDH	RFFL_HUMAN	Affects Expression	[12]
AP-2 complex subunit mu (AP2M1)	OTQCOSFN	AP2M1_HUMAN	Affects Expression	[12]
Ribosomal protein eL39-like 2 (RPL39L)	OTAV1MJQ	RL39L_HUMAN	Affects Expression	[12]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Increases Expression	[28]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Expression	[19]
Protein sprouty homolog 4 (SPRY4)	OT2VK9N0	SPY4_HUMAN	Affects Expression	[12]
Soluble lamin-associated protein of 75 kDa (FAM169A)	OT2FDMA1	F169A_HUMAN	Affects Expression	[12]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3)	OTOM3BUH	SO1B3_HUMAN	Increases Uptake	[14]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
PBC	DCDR1RC	N. A.	Phase 1	[29]

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