Details of the Drug Combinations

General Information of This Drug (ID: DMJYCVW)

• Drug Name: Warfarin (DMJYCVW)
• Synonyms: Brumolin; Choice; Coumadin; Coumafen; Coumafene; Coumaphen; Coumaphene; Coumarins; Coumefene; Dethmor; Dethnel; Kumader; Kumadu; Kumatox; Kypfarin; Maveran; Panwarfin; Prothromadin; RAX; Ratorex; Ratoxin; Ratron; Rattentraenke; Rattunal; Rodafarin; Rosex; Sofarin; Solfarin; Warfarat; Warfarina; Warfarine; Warfarinum; Warficide; Zoocoumarin; Arab Rat Death; Arab rat deth; Coumafene [French]; Dicusat E; Eastern states duocide; Fasco fascrat powder; Maag Rattentod Cum; Mouse pak; Ratron G; Rattenstreupulver Neu Schacht; Rattenstreupulver new schacht; Rodafarin C; Rodex blox; Sorexa plus; Temus W; Twin light rat away; Vampirinip II; Vampirinip iii; Warfarin Q; Warfarin plus; Warfarin plus [discontinued]; Zoocoumarin [Netherlands and USSR]; Zoocoumarin [Russian]; CBKinase1_000192; CBKinase1_012592; Latka 42; Latka 42 [Czech]; PS104_SUPELCO; WARF compound 42; Warf 10; Warf 42; Athrombine-K; CO-Rax; Choice (TN); Coumadin (TN); D-Con; Frass-Ratron; Jantoven (TN); Liqua-tox; Mar-Frin; Marevan (TN); Place-pax; Rac-Warfarin; Rat & mice bait; Rat-Gard; Rat-Kill; Rat-Mix; Rat-Ola; Rat-Trol; Ratten-Koederrohr; Ro-Deth; Rough & ready mouse mix; Tox-hid; Waran (TN); Warfarin (INN); Warfarin (and salts of); Warfarin [BSI:ISO]; Warfarin [INN:BAN]; Warfarin(R); Warfarina [INN-Spanish]; Warfarine [INN-French]; Warfarine [ISO-French]; Warfarinum [INN-Latin]; Cov-R-Tox; Martin's mar-frin; Rat-B-gon; Rat-a-way; Rats-no-more; Spray-trol brand roden-trol; Rat-o-cide #2; Warfarin titrated to an INR of 2.5-3.0; W.A.R.F. 42; (-)-Warfarin; (S)-Warfarin; 200 coumarin

Indication

Atrial fibrillation; ICD 11: BC81.3; Status: Approved [1]; Deep vein thrombosis; ICD 11: BD71; Status: Approved [2]; Pulmonary hypertension; ICD 11: BB01; Status: Approved [2]; Thrombosis; ICD 11: DB61-GB90; Status: Application submitted [3]; Intracranial embolism; ICD 11: 8B22.1; Status: Investigative [2]; Venous thromboembolism; ICD 11: BD72; Status: Investigative [2]

• Therapeutic Class: Anticoagulants
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

25 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Casopitant + Warfarin	DC68SUY	Casopitant	Nausea and Vomiting, Chemotherapy-Induced	[4]
Ceritinib + Warfarin	DCN801X	Ceritinib	ALK-positive Advanced Tumors	[5]
Dapagliflozin + Warfarin	DCWP81J	Dapagliflozin	Type 2 Diabetes Mellitus	[6]
Duloxetine + Warfarin	DCUD2H7	Duloxetine	Anticoagulant Effect of Warfarin When Taken With Duloxetine.	[7]
Edivoxetine + Warfarin	DCOF722	Edivoxetine	Major Depressive Disorder	[8]
Enzastaurin + Warfarin	DCCNBQT	Enzastaurin	Solid Tumor	[9]
FG-4592 + Warfarin	DC1LTA9	FG-4592	Pharmacokinetics of FG-4592	[10]
Fostamatinib + Warfarin	DCWG8B5	Fostamatinib	Rheumatoid Arthritis	[11]
Heparin + Warfarin	DCKIJUN	Heparin	Mesenteric Vein Thrombosis	[12]
Heparin + Warfarin	DCQXO7X	Heparin	Deep Vein Thrombosis	[13]
Phenindione + Warfarin	DCSPC1B	Phenindione	Anticoagulation in Pregnancy	[14]
Propranolol + Warfarin	DCUW2BL	Propranolol	Portal Vein Thrombosis	[15]
Warfarin + Fondaparinux sodium	DCGM91U	Fondaparinux sodium	Heparin-Induced Thrombocytopenia	[16]
Warfarin + Isavuconazole	DCKI6Z3	Isavuconazole	Pharmacokinetics of Isavuconazole	[17]
Warfarin + DIMEBOLIN	DCPJRTI	DIMEBOLIN	Alzheimer's Disease	[18]
Warfarin + Imrecoxib	DCUKE47	Imrecoxib	Knee Osteoarthritis	[19]
Warfarin + Rivaroxaban	DCD86UT	Rivaroxaban	Valvular Heart Disease	[20]
Apixaban + Warfarin	DCQQ11V	Apixaban	Acute Myocardial Infarction	[21]
Heparin + Warfarin	DCU1FOO	Heparin	Atrial Fibrillation	[22]
Propranolol + Warfarin	DCKKWD5	Propranolol	Portal Vein, Cavernous Transformation of	[23]
Acenocoumarol + Warfarin	DCSN72G	Acenocoumarol	Diabetes	[24]
Aspirin + Warfarin	DCNUAO5	Aspirin	Aortic Valve Stenosis	[25]
Aspirin + Warfarin	DCWWEL9	Aspirin	Complications Due to Heart Valve Prosthesis	[26]
Oritavancin + Warfarin	DCCXVOI	Oritavancin	Acute Bacterial Skin and Skin Structure Infection	[27]
Warfarin + Oseltamivir	DC1CVGE	Oseltamivir	Drug Therapy, Combination	[28]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6853).
• [2] Warfarin FDA Label
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] ClinicalTrials.gov (NCT00404274) A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers
• [5] ClinicalTrials.gov (NCT02422589) A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors
• [6] ClinicalTrials.gov (NCT00904176) Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
• [7] ClinicalTrials.gov (NCT00533026) Duloxetine - Warfarin Pharmacodynamic Study
• [8] ClinicalTrials.gov (NCT01263119) A Study of LY2216684 and Warfarin in Healthy Subjects
• [9] ClinicalTrials.gov (NCT01388335) A Drug Interaction Study to Assess the Effect of LY317615 on the Metabolic Pathway of Warfarin
• [10] ClinicalTrials.gov (NCT02252731) A Study to Evaluate the Effects of Multiple Doses of FG-4592 on the Exposure, Safety and Tolerability and Effect of Warfarin in Healthy Subjects
• [11] ClinicalTrials.gov (NCT01311622) Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy Subjects
• [12] ClinicalTrials.gov (NCT03483207) Acute Mesenteric Venous Thrombosis.. in Assiut University Hospital Management Controversies
• [13] ClinicalTrials.gov (NCT01780987) AStudy To Evaluate Safety And Eficacy Of Apixaban In Japanese Acute Deep Vein Thrombosis (DVT) And Pulmonary Embolism (PE) Patients
• [14] ClinicalTrials.gov (NCT01758640) Safety And Efficacy of Low Dose Oral Anticoagulants And Aspirin Therapy
• [15] ClinicalTrials.gov (NCT02485184) TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
• [16] ClinicalTrials.gov (NCT00673439) Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT)
• [17] ClinicalTrials.gov (NCT01657825) Drug Interaction Study of Isavuconazole and Warfarin in Healthy Male Subjects
• [18] ClinicalTrials.gov (NCT00827034) A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects
• [19] ClinicalTrials.gov (NCT02426060) A Drug Drug Interaciton Study of Imrecoxib and Warfarin in Healthy Volunteers
• [20] ClinicalTrials.gov (NCT02303795) RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial
• [21] ClinicalTrials.gov (NCT03232398) Apixaban Versus Warfarin in Patients With Left Ventricular (LV) Thrombus
• [22] ClinicalTrials.gov (NCT02072434) Edoxaban vs. Warfarin in Subjects Undergoing Cardioversion of Nonvalvular Atrial Fibrillation (NVAF)
• [23] ClinicalTrials.gov (NCT02853526) TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
• [24] ClinicalTrials.gov (NCT02935855) ORal anticoaGulants in diAbetic and Nondiabetic Patients With nOn-valvular Atrial fibrillatioN (ORGANON)
• [25] ClinicalTrials.gov (NCT03807921) Anticoagulation for Aortic Bioprosthesis (ANTIPRO)
• [26] ClinicalTrials.gov (NCT02022527) Cost Effectiveness Analysis In Patients With Heart Valve Prosthesis
• [27] ClinicalTrials.gov (NCT02452918) A Study to Evaluate the Safety of a Single Intravenous (IV) Dose of Orbactiv (Oritavancin) in Participants on Chronic Warfarin Therapy Being Treated For Acute Bacterial Skin and Skin Structure Infection (ABSSSI)
• [28] ClinicalTrials.gov (NCT02780622) A Pharmacokinetics, Pharmacodynamics and Safety Study of Warfarin in Combination With Tamiflu (Oseltamivir)