Details of the Drug Combinations

General Information of This Drug (ID: DMU73F0)

Drug Name

Bifemelane DMU73F0

Synonyms

Alnert; Celeport; E-0687; MCI-2016; SON-216

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Terminated	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

15 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bifemelane + Docetaxel	DCCWVBF	Docetaxel	DD2 (Cell Line: DD2)	[2]
Bifemelane + Quinine	DCLORM4	Quinine	DD2 (Cell Line: DD2)	[2]
Bifemelane + Mefloquine	DC175SE	Mefloquine	DD2 (Cell Line: DD2)	[2]
Bifemelane + Nitisinone	DCVC7J4	Nitisinone	DD2 (Cell Line: DD2)	[2]
Bifemelane + Vorinostat	DC36P96	Vorinostat	DD2 (Cell Line: DD2)	[2]
Bifemelane + Atovaquone	DCMIEMS	Atovaquone	DD2 (Cell Line: DD2)	[2]
Bifemelane + OZ277	DC7WKOI	OZ277	Hepatoblastoma (Cell Line: HB3)	[3]
Bifemelane + Ivermectin	DCA4M0N	Ivermectin	Hepatoblastoma (Cell Line: HB3)	[3]
Bifemelane + MK-4815	DCKT16H	MK-4815	Hepatoblastoma (Cell Line: HB3)	[3]
Bifemelane + Vorinostat	DCB33AG	Vorinostat	Hepatoblastoma (Cell Line: HB3)	[3]
Bifemelane + Atovaquone	DCSW1SA	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Bifemelane	DCAN9S7	Dihydroergotamine	Hepatoblastoma (Cell Line: HB3)	[2]
Omacetaxine mepesuccinate + Bifemelane	DCQMMSO	Omacetaxine mepesuccinate	DD2 (Cell Line: DD2)	[2]
SB 228357 + Bifemelane	DCX5BX5	SB 228357	DD2 (Cell Line: DD2)	[2]
Sorafenib + Bifemelane	DC3OSQR	Sorafenib	DD2 (Cell Line: DD2)	[2]
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⏷ Show the Full List of 15 DrugCom(s)

References

1	4-(O-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(O-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J Neurochem. 1988 Jan;50(1):243-7.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.