Details of the Drug Combinations

General Information of This Drug (ID: DMVS9WQ)

Drug Name
Nitisinone   DMVS9WQ
Synonyms
Nitisinona; Nitisinonum; Nitisone; Orfadin; Nitisinone [INN]; SC 0735; FE-0200; Nitisinone (NTBC); Nitisinone [USAN:INN]; Orfadin (TN); Nitisinone (JAN/USAN/INN); 2-(2-Nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione; 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-(Alpha,alpha,alpha-trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione; 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; 2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione
Indication
Disease Entry ICD 11 Status REF
Hereditary tyrosinemia type 1 5C50.11 Approved [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

95 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Nitisinone DC7YMHN Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atovaquone + Nitisinone DCX5GCE Atovaquone DD2 (Cell Line: DD2) [2]
Atovaquone + Nitisinone DC47AAF Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Bifemelane + Nitisinone DCVC7J4 Bifemelane DD2 (Cell Line: DD2) [2]
Brincidofovir + Nitisinone DC95AXB Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bumetanide + Nitisinone DC3RS26 Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Nitisinone DCZZ1FS Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + Nitisinone DCZVK3Q Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Nitisinone DCO7AAI Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dactinomycin + Nitisinone DC871P2 Dactinomycin DD2 (Cell Line: DD2) [3]
Dantrolene + Nitisinone DCVLCPK Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dihydroergotamine + Nitisinone DCUCA12 Dihydroergotamine DD2 (Cell Line: DD2) [2]
Docetaxel + Nitisinone DC01LIP Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Nitisinone DCY2DEZ Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Emetine + Nitisinone DC7671Z Emetine DD2 (Cell Line: DD2) [2]
Entacapone + Nitisinone DC9VXAJ Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Nitisinone DC2AARR Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + Nitisinone DCW1BZH Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Nitisinone DCFSBTI Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Nitisinone DCYDQFG Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Nitisinone DCMURHS Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metaxalone + Nitisinone DCRBGB3 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Miconazole + Nitisinone DCPSS31 Miconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
MK-4815 + Nitisinone DC4WM6F MK-4815 DD2 (Cell Line: DD2) [2]
Mycophenolic acid + Nitisinone DCC8217 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nabilone + Nitisinone DC0VPX0 Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nilotinib + Nitisinone DCP8EML Nilotinib DD2 (Cell Line: DD2) [2]
Nitisinone + Aprepitant DC2CB1U Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Pentostatin DCF1UNE Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Gefitinib DCVBGCM Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Lumefantrine DC2QKUX Lumefantrine DD2 (Cell Line: DD2) [2]
Nitisinone + Kanamycin DCEO1PP Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Dactinomycin DCS0E3T Dactinomycin DD2 (Cell Line: DD2) [2]
Nitisinone + T-3.5 DCN58EC T-3.5 DD2 (Cell Line: DD2) [2]
Nitisinone + T-3.5 DCFXAK7 T-3.5 Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + GYKI-52466 DC5LZLJ GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Artemether DCAI961 Artemether DD2 (Cell Line: DD2) [2]
Nitisinone + PMID28460551-Compound-2 DCBFRIG PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Dihydroergotamine DCNIZ7E Dihydroergotamine DD2 (Cell Line: DD2) [2]
Nitisinone + Vinblastine DCOGCVL Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Mephenytoin DCQPVBS Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Doxycycline DCWFY47 Doxycycline Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + IT-141 DCQ2JR9 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Buspirone DCN4E6L Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Metyrosine DCGKOIA Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Emetine DCX2ELU Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Fluspirilene DCI5IEN Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + WAY-100635 DC2PAQE WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Pentamidine DC6DNMV Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Arfolitixorin DC4BW2K Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + PF-02545920 DCNI90N PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Tiagabine DCRPS5V Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Diazoxide DC21AUY Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Idarubicin DCOAZJQ Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Nitisinone + Epothilone B DC7696Z Epothilone B Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + Imatinib DCIH7QP Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Bortezomib DCZ15GN Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Methylene blue DCAE52V Methylene blue DD2 (Cell Line: DD2) [2]
Nitisinone + Methylene blue DC7BQ21 Methylene blue Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + Ethinyl estradiol DCG4HTI Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Trimethobenzamide DC938PP Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Amiloride DCIVA4S Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Chloroquine DCTJ52D Chloroquine DD2 (Cell Line: DD2) [2]
Nitisinone + Chloroquine DC1ZWIJ Chloroquine Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + MK-4815 DCP51LR MK-4815 DD2 (Cell Line: DD2) [2]
Nitisinone + MK-4815 DC1R37L MK-4815 Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + Mycophenolic acid DC4XBPI Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Ritonavir DCPMM91 Ritonavir Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + Oxandrolone DC15HQ2 Oxandrolone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Mefloquine DC3JM7R Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Mefloquine DCPXX4B Mefloquine DD2 (Cell Line: DD2) [2]
Nitisinone + Mefloquine DC7O0C4 Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
Nitisinone + Doxorubicin DCLFF2J Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Olmesartan medoxomil DC4HOTI Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Auranofin DCIO8IO Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Vorinostat DCKXBSV Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Estramustine DCLIQMN Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Cerivastatin DCSNI6D Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Atovaquone DC5P6RS Atovaquone DD2 (Cell Line: DD2) [2]
Nitisinone + Atovaquone DCUE3R1 Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Panobinostat + Nitisinone DCHVTNH Panobinostat DD2 (Cell Line: DD2) [2]
Pargyline + Nitisinone DCCTI79 Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Nitisinone DCMTJM0 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrimethamine + Nitisinone DC8UEX6 Pyrimethamine Hepatoblastoma (Cell Line: HB3) [2]
Sarpogrelate + Nitisinone DCGVY25 Sarpogrelate Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Nitisinone DCLUBQZ SB 228357 Hepatoblastoma (Cell Line: HB3) [3]
Silver sulfadiazine + Nitisinone DCY8T22 Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Spironolactone + Nitisinone DCQI4WI Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + Nitisinone DCWVSOB Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tranylcypromine + Nitisinone DCTDS34 Tranylcypromine DD2 (Cell Line: DD2) [2]
Trichostatin A + Nitisinone DC4QHDN Trichostatin A DD2 (Cell Line: DD2) [2]
Triiodothyronine + Nitisinone DCCEKY4 Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Verapamil + Nitisinone DC2PNGZ Verapamil DD2 (Cell Line: DD2) [3]
ZM-447439 + Nitisinone DCGITW3 ZM-447439 DD2 (Cell Line: DD2) [2]
ZSTK474 + Nitisinone DCG6JM9 ZSTK474 DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 95 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Nitisinone + Nitisinone DCHX9YY Nitisinone Hereditary Tyrosinemia, Type I [4]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6834).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT02750345) Bioequivalence Study of Two Oral Nitisinone Formulations to Treat Hereditary Tyrosinemia (HT-1)