Details of the Drug Combinations

General Information of This Drug (ID: DMXLZP6)

Drug Name

Metaxalone DMXLZP6

Synonyms

Skelaxin

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

96 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Metaxalone	DC0DFBK	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Acarbose + Metaxalone	DCAK0NT	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Acitretin + Metaxalone	DC6KYDV	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Aliskiren + Metaxalone	DCQVA6K	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Auranofin + Metaxalone	DCVV5E6	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Bortezomib + Metaxalone	DC51WFI	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Brincidofovir + Metaxalone	DCEA222	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cerivastatin + Metaxalone	DCL08DL	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Chlorambucil + Metaxalone	DCOQ5Z7	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cisatracurium + Metaxalone	DCJV0OY	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Clascoterone + Metaxalone	DCF0IJ5	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Crotamiton + Metaxalone	DCVAF7S	Crotamiton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cytarabine + Metaxalone	DC7SWYK	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Diazoxide + Metaxalone	DCFM79D	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Docetaxel + Metaxalone	DCJCNUV	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Doxorubicin + Metaxalone	DC1TWXV	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Emetine + Metaxalone	DC0LXR4	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Ethambutol + Metaxalone	DCYGDBU	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Hydralazine + Metaxalone	DCFAN62	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Hyodeoxycholic acid + Metaxalone	DC63F8G	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
IT-141 + Metaxalone	DCZM44R	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Lefaxin + Metaxalone	DCHNBFK	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Leflunomide + Metaxalone	DCQBG0E	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Levamisole + Metaxalone	DCN5KZX	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Loperamide + Metaxalone	DCNBGT9	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Maprotiline + Metaxalone	DCVVGHR	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mecamylamine + Metaxalone	DC2FQJV	Mecamylamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mefloquine + Metaxalone	DCUF7FS	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Memantine + Metaxalone	DCUU30O	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Aprepitant	DCC9XPP	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Baclofen	DCODTW9	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Gefitinib	DCSWPO4	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Citalopram	DC5W673	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Epinephrine	DCQNZ19	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + PMID28460551-Compound-2	DC9QTIY	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Trioxsalen	DCHR5XR	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Vinblastine	DCD814W	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Anamorelin	DC44YX5	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Triapine	DCS0IYT	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Testosterone cypionate	DC9HQNR	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + SCH 727965	DCUUVS9	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Amodiaquine	DCGZJVF	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Chlorzoxazone	DCGSYZ3	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Metformin	DC7LQBX	Metformin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Docetaxel	DCPDTM1	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Phenprocoumon	DC9ZKE9	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + ETHISTERONE	DCN3SBR	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Methoxsalen	DCXIJTG	Methoxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Phensuximide	DCT5F34	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + VR-776	DCIM3KL	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + WAY-100635	DCPQJ49	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Armodafinil	DCY4IHP	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Naringenin	DCE5YGH	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Tolazoline	DC5KZ1D	Tolazoline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Arfolitixorin	DC6RIWL	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + BIO-300	DCM01BZ	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + PF-02545920	DCFPAAC	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Norcisapride	DCF1MYZ	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Tiagabine	DCDMS8X	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Diazoxide	DCO6VMI	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Idarubicin	DCKC1PH	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Imatinib	DCZ5KLT	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Methylene blue	DCR48SH	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Topotecan	DC5PF6D	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Cefmenoxime	DC8JG66	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Maprotiline	DCXAXXS	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DC4G9WA	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Eptifibatide	DCENISS	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Leflunomide	DCFXZFT	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Novobiocin	DC01S5R	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Brincidofovir	DCQS52K	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Valproic Acid	DCOZDA9	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Quinine	DCKMIPD	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Mycophenolic acid	DCN0CPQ	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Iloprost	DC6ZURF	Iloprost	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Nabilone	DC0EZEK	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Nitisinone	DCRBGB3	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Sumatriptan	DC2PCMW	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + FORMESTANE	DCCBZOE	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Vorinostat	DC90GFF	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Cerivastatin	DCMLQU7	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Cytarabine	DCW9GJN	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metaxalone + Cilostazol	DCDJ0R5	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metyrosine + Metaxalone	DC0KMSI	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Nitrosoglutathione + Metaxalone	DCU65EU	Nitrosoglutathione	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Nizatidine + Metaxalone	DC7W6BH	Nizatidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Paromomycin + Metaxalone	DC051KU	Paromomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pazopanib + Metaxalone	DCQKB15	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pepstatin + Metaxalone	DCJ2X6C	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Phensuximide + Metaxalone	DCEB8T1	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
PMID28460551-Compound-2 + Metaxalone	DC813BO	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pomalidomide + Metaxalone	DCZZDD7	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Primidone + Metaxalone	DCE8GNU	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pyrazinamide + Metaxalone	DC86MZX	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Terazosin + Metaxalone	DCMA7XJ	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Tiagabine + Metaxalone	DCP915N	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
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⏷ Show the Full List of 96 DrugCom(s)

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ibuprofen + Metaxalone	DCTWLPP	Ibuprofen	Low Back Pain	[3]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7609).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT03068897) Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain