Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXV6YP)

• Drug Name: Fus-1 tumor suppressor gene therapy Drug Info
• Synonyms: Fus-1 tumor suppres; INGN-401; P53 bystander effector, Introgen; DOTAP:chol-TUSC2; FUS1-DOTAP:cholesterol; Fus-1 tumor suppressor gene therapy - nanoparticle formulation (cancer); Fus-1 tumor suppressor gene therapy-nanoparticle formulation (cancer), MD Anderson

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Phase 1/2	[1]

• Cross-matching ID: TTD Drug ID: DMXV6YP

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor suppressor candidate 2 (TUSC2)	TTJ8O14	TUSC2_HUMAN	Suppressor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tumor suppressor candidate 2 (TUSC2)	DTT	TUSC2	3.878	5.875	6.032	5.725

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Non-small-cell lung cancer
• ICD Disease Classification: 2C25.Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor suppressor candidate 2 (TUSC2)	DTT	TUSC2	3.62E-08	-0.16	-0.72

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018766)
• [2] INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201. Drugs R D. 2007;8(3):176-87.