General Information of Drug (ID: DMXWL0N)

Drug Name
FR-133605 Drug Info
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Terminated [1]
Cross-matching ID
TTD Drug ID
DMXWL0N

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 1 receptor type 2 (IL1R2) TT51DEV IL1R2_HUMAN Modulator [1]
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tumor necrosis factor (TNF) DTT TNF 5.692 3.07 4.413 1.202
Interleukin 1 receptor type 2 (IL1R2) DTT IL1R2 5.498 7.408 6.23 2.766
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Arthritis
ICD Disease Classification FA20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor necrosis factor (TNF) DTT TNF 8.51E-01 0.05 0.27
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83.