Details of the Drug

General Information of Drug (ID: DMXWL0N)

Drug Name

FR-133605

Indication

Disease Entry	ICD 11	Status	REF
Arthritis	FA20	Terminated	[1]
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Structure

3D Structure is Not Available

3D MOL

2D MOL

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 1 receptor type 2 (IL1R2)	TT51DEV	IL1R2_HUMAN	Modulator	[1]
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Modulator	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Arthritis

ICD Disease Classification

FA20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor necrosis factor (TNF)	DTT	TNF	8.51E-01	0.05	0.27

Molecular Expression Atlas (MEA)

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References

1	Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83.