Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1A6RV)

Drug Name

Interferon beta-1a Drug Info

Synonyms

Avonex; Avonex (TN); Cinnovex (TN); Interferon beta-1a (USAN); Interferon beta-1a (genetical recombination); Interferon beta-1a (genetical recombination) (JAN); Rebif (TN)

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[2]

Therapeutic Class

Immunomodulatory Agents

Cross-matching ID

TTD Drug ID: DM1A6RV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interferon-beta (IFNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PEGylated IFN beta 1-a	DMRH0D5	Type-2 diabetes	5A11	Approved	[4]
PLEGRIDY	DMAKXW9	Multiple sclerosis	8A40	Approved	[5]
FP-1201	DM823WQ	Acute lung injury	NB32.3	Phase 3	[6]
NU-100	DMA16IL	Multiple sclerosis	8A40	Phase 3	[7]
Biferonex	DM57B9J	Multiple sclerosis	8A40	Phase 3	[8]
AZ-01, PEGylated interferon-beta	DMHFUJT	Multiple sclerosis	8A40	Phase 2	[7]
PF-06823859	DM8C1H4	Dermatomycosis	EA60	Phase 2	[9]
Interferon beta 1a	DMQSA7H	Discovery agent	N.A.	Phase 2	[10]
ARX-424	DM4CZ2Y	Multiple sclerosis	8A40	Phase 1	[7]
Gene therapy, IFN-b	DMJP83V	Glioblastoma multiforme	2A00.0	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-beta (IFNB1)	TT4TZ8J	IFNB_HUMAN	Modulator	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8339).
2	ClinicalTrials.gov (NCT04315948) Trial of Treatments for COVID-19 in Hospitalized Adults
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol. 2014 Jul;13(7):657-65.
5	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
6	The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study.Lancet Respir Med. 2014 Feb;2(2):98-107.
7	PEGylated interferon beta-1a in the treatment of multiple sclerosis - an update. Biologics. 2013; 7: 131-138.
8	Improving compliance with interferon-beta therapy in patients with multiple sclerosis. CNS Drugs. 2009;23(6):453-62.
9	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
11	Interferon-beta gene therapy for cancer: basic research to clinical application. Cancer Sci. 2004 Nov;95(11):858-65.