Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1C9W3)

Drug Name
S-(N-methyl-N-hydroxycarbamoyl)glutathione Drug Info
Synonyms
S-Hmcg; S-(N-Hydroxy-N-methylcarbamoyl)glutathione; CHEMBL129435; 144810-23-1; AC1L2R0C; S-(N-methyl-N-hydroxycarbamoyl)glutathione; SCHEMBL3009083; DTXSID00162814; CHEBI:313255; BDBM50092823; S-(Methylhydroxycarbamoyl)glutathione; s-(n-hydroxy-n-methylcarbamoyl) glutathione; C04572; Glycine, N-(N-L-gamma-glutamyl-S-((hydroxymethylamino)carbonyl)-L-cysteinyl)-; (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-[hydroxy(methyl)carbamoyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
126845
ChEBI ID
CHEBI:313255
CAS Number
CAS 144810-23-1
TTD Drug ID
DM1C9W3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Lactoylglutathione lyase (GLO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [2]
NARINGENIN DMHAZLM N. A. N. A. Phase 1 [2]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [3]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [2]
S-(N-butyl-N-hydroxycarbamoyl)glutathione DMU7EQV Discovery agent N.A. Investigative [1]
S-(N-heptyl-N-hydroxycarbamoyl)glutathione DMV6T1Q Discovery agent N.A. Investigative [1]
S-(N-propyl-N-hydroxycarbamoyl)glutathione DMRFKZ6 Discovery agent N.A. Investigative [1]
S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione DM1AHIW Discovery agent N.A. Investigative [3]
S-(N-pentyl-N-hydroxycarbamoyl)glutathione DM4E9J2 Discovery agent N.A. Investigative [1]
S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione DM3FXPV Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Lactoylglutathione lyase (GLO1) TTV9A7R LGUL_HUMAN Inhibitor [1]

References

1 Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6.
2 Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75.
3 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.