Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1NOEK)

Drug Name
Metreleptin Drug Info
Indication
Disease Entry ICD 11 Status REF
Acquired generalized lipodystrophy Approved [1]
Congenital generalized lipodystrophy Approved [1]
Diabetic complication 5A2Y Approved [2]
Acquired partial lipodystrophy Investigative [1]
Cross-matching ID
TTD Drug ID
DM1NOEK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Leptin receptor (LEPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AMPE4L DM64X25 Diabetic complication 5A2Y Investigative [4]
PEGylated leptin DMZ01PS Obesity 5B81 Investigative [4]
BL-5040 DMGULNZ Cachexia MG20 Investigative [4]
ANG-2004 DMK1IMC Obesity 5B81 Investigative [4]
AMPSL DMXRIUT Diabetic complication 5A2Y Investigative [4]
Leptin DM5LY1H Alzheimer disease 8A20 Investigative [4]
EDP-21 DMMN0GO Obesity 5B81 Investigative [4]
AMPPL DMVHOQE Diabetic complication 5A2Y Investigative [4]
PEG-LPA-2 DMY293M Solid tumour/cancer 2A00-2F9Z Investigative [4]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leptin receptor (LEPR) TT0HD6V LEPR_HUMAN Modulator [3]

References

1 Lipodystrophy Syndromes. Endocrinol Metab Clin North Am. 2016 Dec;45(4):783-797.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7333).
3 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).