Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1SDN8)

Drug Name

HOMOERIODICTYOL Drug Info

Synonyms

Homoeriodictyol; (-)-Homoeriodictyol; 446-71-9; Eriodictyonone; UNII-EHE7H3705C; Eriodictyol 3'-methyl ether; 5,7,4'-Trihydroxy-3'-methoxyflavanone; CHEMBL490170; EHE7H3705C; CHEBI:74960; (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone; Q-100585; (+/-)-Homoeriodictyol; cyanidanon-3-methyl ether 1625; EINECS 207-173-3; AC1Q6KID; AC1L2K7J; SCHEMBL39497; DTXSID30196243; FTODBIPDTXRIGS-ZDUSSCGKSA-N; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-; ZINC4098322; BDBM50325672

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 73635
ChEBI ID: CHEBI:74960
CAS Number: CAS 446-71-9
TTD Drug ID: DM1SDN8

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PINOCEMBRIN	DM96VWD	N. A.	N. A.	Phase 2	[1]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[1]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[1]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[1]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[1]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[1]
ACACETIN	DMQOB0X	Discovery agent	N.A.	Investigative	[1]
TRISMETHOXYRESVERATROL	DM6USPC	Discovery agent	N.A.	Investigative	[4]
Galangin	DM5TQ2O	Discovery agent	N.A.	Investigative	[1]
CHRYSOERIOL	DM96ECL	Discovery agent	N.A.	Investigative	[1]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[36]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[37]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[38]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[39]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[40]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[41]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[42]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[5]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[6]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[7]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[10]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[11]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[13]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[14]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[20]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[24]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[30]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[33]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cytochrome P450 1B1 (CYP1B1)	TTI84H7	CP1B1_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[2]
Glutamate--cysteine ligase regulatory subunit (GCLM)	OT6CP234	GSH0_HUMAN	Gene/Protein Processing	[3]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Gene/Protein Processing	[3]

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References

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