Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4ZLUH)

Drug Name
LUPEOL Drug Info
Synonyms
Fagarsterol; Lupenol; EINECS 208-889-9; NSC 90487; (3-beta)-Lup-20(29)-en-3-ol; Lup-20(29)-en-3-ol, (3beta)-; (1R,3aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropenyl-3a,5a,5b,8,8,11a-hexamethyl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol; Lup-20(29)-en-3-ol; Lup-20(29)-en-3-beta-ol; Lup-20(29)-en-3-ol, (3-beta)-; Lup-20(29)-en-3-ol, (3.beta.)-; AC1L2J5Q; SCHEMBL561024; Lup-20(29)-en-3beta-ol; LS-88199; AN-14996
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
259846
ChEBI ID
CHEBI:6570
CAS Number
CAS 545-47-1
TTD Drug ID
DM4ZLUH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [5]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [6]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [5]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [7]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [5]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [5]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [8]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [5]
Podofilox DMT2EJP Condyloma 1A95 Approved [9]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [10]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [11]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [12]
Fructose DM43AN2 Vomiting MD90 Approved [13]
Ketoprofen DMRKXPT Bursitis Approved [13]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [15]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [16]
Gefitinib DM15F0X Colon adenocarcinoma Approved [17]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Gefitinib DM15F0X Colon adenocarcinoma Approved [22]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [23]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [27]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [28]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [32]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [25]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [29]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [35]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [37]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [38]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [13]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [39]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [40]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [15]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [41]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [44]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [45]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [50]
Panobinostat DM58WKG Chronic graft versus host disease Approved [51]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [60]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [61]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [64]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [65]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [66]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [68]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [69]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [70]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [71]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [72]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [73]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [40]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [76]
Meloxicam DM2AR7L Arthritis FA20 Approved [77]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [78]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [79]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [87]
Testosterone DM7HUNW Hot flushes GA30 Approved [88]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [35]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [71]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [39]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [42]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [74]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Meloxicam DM2AR7L Arthritis FA20 Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [93]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [94]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [95]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Gefitinib DM15F0X Colon adenocarcinoma Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [98]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [2]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [3]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [3]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Gene/Protein Processing [3]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Gene/Protein Processing [4]

References

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62 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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