Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6HGUL)

Drug Name

5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine Drug Info

Synonyms

MHZPA; 112621-42-8; 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine; 5'-Deoxy-5'-(N-methyl-N-(3-hydrazinopropyl)amino)adenosine; 5'-Deoxy-5'-((3-hydrazinopropyl)methylamino)adenosine; Adenosine, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]-; MHZ; Adenosine, 5'-deoxy-5'-((3-hydrazinopropyl)methylamino)-; AC1L3TYJ; SCHEMBL952217; Adenosine,5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]- (9CI); CTK4A7899; DTXSID50150125; AKOS030589592; 5'-[(3-Hydrazinopropyl)methylamino]-5'-deoxyadenosine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 122092
CAS Number: CAS 112621-42-8
TTD Drug ID: DM6HGUL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tromethamine	DMOBLGK	Acidosis	5C73	Approved	[2]
ORG 34517/34850	DMR3P98	Mood disorder	6A60-6E23	Phase 2	[3]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[2]
MGBG	DM9GOT6	Head and neck cancer	2D42	Terminated	[3]
CGP-40215A	DM69YWS	Pneumocystis pneumonia	CA40.20	Terminated	[4]
5'-Deoxy-5'-(N,N-dimethylamino)adenosine	DMF7JPO	Discovery agent	N.A.	Investigative	[5]
Hydroxyalanine	DM5HWZY	Discovery agent	N.A.	Investigative	[6]
5'-Deoxy-5'-dimethylsulfonioadenosine chloride	DM1NAMK	Discovery agent	N.A.	Investigative	[5]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine	DM3WDOY	Discovery agent	N.A.	Investigative	[5]
5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine	DMT6D5V	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)	TTVF2BJ	SIAT9_HUMAN	Inhibitor	[1]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[1]

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References

1	S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
4	Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
5	New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.