Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM74LZK)

• Drug Name: Cromoglicate Drug Info
• Synonyms: Crolom (TN); Intal (TN); Nasalcrom (TN); Opticrom (TN); Optrex Allergy (TN); Prevalin (TN); Rynacrom (TN)

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Approved	[1]
Vernal keratoconjunctivitis		Approved	[2]
Allergic rhinitis	CA08.0	Terminated	[3]
Giant papillary conjunctivitis		Investigative	[4]

• Therapeutic Class: Antiasthmatic Agents
• Cross-matching ID:
  PubChem CID: 2882
  ChEBI ID: CHEBI:59773
  CAS Number: CAS 16110-51-3
  TTD Drug ID: DM74LZK
  ACDINA Drug ID: D00971

Molecule-Related Drug Atlas

Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[5]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[6]
BIIB-021	DMPAJ41	Breast cancer	2C60-2C65	Phase 2	[7]
KW-2478	DMJGL72	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
VER 50589	DMFLZPC	Breast cancer	2C60-2C65	Phase 2	[6]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[9]
Efungumab	DMBHP56	Breast cancer	2C60-2C65	Phase 2	[10]
SNX-5422	DMIU0VP	Haematological malignancy	2B33.Y	Phase 1/2	[11]
PU3	DMJO0BP	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
Debio 0932	DMWP3G1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 90 alpha (HSP90A)	TT78R5H	HS90A_HUMAN	Inhibitor	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7608).
• [2] Twenty-first century mast cell stabilizers. Br J Pharmacol. 2013 Sep;170(1):23-37.
• [3] Sodium cromoglicate: an ineffective drug or meta-analysis misused Pharm Stat. 2007 Apr-Jun;6(2):123-37.
• [4] Diagnostics and new developments in the treatment of ocular allergies. Curr Allergy Asthma Rep. 2012 Jun;12(3):232-9.
• [5] Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41.
• [6] Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82.
• [7] BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther. 2009 Apr;8(4):921-9.
• [8] Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012 Apr;2(4):e68.
• [9] Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin Investig Drugs. 2009 Jun;18(6):861-8.
• [10] Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009 Nov;43(11):1818-23.
• [11] SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hema... Blood. 2009 Jan 22;113(4):846-55.
• [12] Clinical pipeline report, company report or official report of Debiopharm (2011).