General Information of Drug (ID: DM8L4Z0)

Drug Name
Napsagatran Drug Info
Synonyms Ro-46-6240
Indication
Disease Entry ICD 11 Status REF
Myocardial infarction BA41-BA43 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
6918278
CAS Number
CAS 154397-77-0
TTD Drug ID
DM8L4Z0

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Drug(s) Targeting Coagulation factor IIa (F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Argatroban DMFI46A Thrombosis DB61-GB90 Approved [3]
Pyridoxal Phosphate DMO2K0J Malnutrition 5B50-5B71 Approved [4]
Bivalirudin DMECRX1 Thrombocytopenia 3B64 Approved [5]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [6]
Dabigatran DMDI6R4 Stroke 8B20 Approved [7]
Desirudin Recombinant DM2BTFN Coagulation defect 3B10.0 Approved [8]
Human prothrombin complex concentrate DMPHVQ1 Bleeding disorder GA20-GA21 Approved [9]
Lepirudin DM1I3D5 Thrombocytopenia 3B64 Approved [10]
Anisindione DM2C48U Coagulation defect 3B10.0 Approved [11]
ATryn antithrombin DM79Y2T Multiple sclerosis 8A40 Approved [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor IIa (F2) TT6L509 THRB_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004026)
2 Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther. 1996 Apr;277(1):71-8.
3 Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation. J Biol Chem. 2002 Dec 27;277(52):50439-44.
4 New antithrombotic drugs (excluding plasminogen activators. Arch Mal Coeur Vaiss. 2001 Nov;94(11 Suppl):1225-32.
5 New anticoagulants. Am Heart J. 2001 Aug;142(2 Suppl):S3-8.
6 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
7 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362).
10 Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis. Kidney Int Suppl. 1999 Nov;(72):S46-50.
11 Anticoagulation with anisindione in a patient with a warfarin-induced skin eruption. Pharmacotherapy. 2003 Apr;23(4):533-6.
12 Antithrombin III Utilization in a Large Teaching Hospital. P T. 2013 December; 38(12): 764-767, 779.