Details of the Drug

General Information of Drug (ID: DM2C48U)

Drug Name
Anisindione
Synonyms
Anisindiona; Anisindionum; Miradon; Unidone; Anisin indandione; SPE 2792; Anisindiona [INN-Spanish]; Anisindione (INN); Anisindione [INN:BAN]; Anisindionum [INN-Latin]; Miradon (TN); 2-(4-Methoxy-phenyl)-indan-1,3-dione; 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione; 2-(4-Methoxyphenyl)indan-1,3-dione; 2-(4-methoxyphenyl)indene-1,3-dione; 2-(p-Methoxyphenyl)-1,3-indandione; 2-(p-Methoxyphenyl)indane-1,3-dione; 2-[4-(methyloxy)phenyl]-1H-indene-1,3(2H)-dione; 2-p-Anisyl-1,3-indandione; 2-para-Anisyl-1,3-indandione
Indication
Disease Entry ICD 11 Status REF
Coagulation defect 3B10.0 Approved [1]
Therapeutic Class
Anticoagulants
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 252.26
Logarithm of the Partition Coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C16H12O3
IUPAC Name
2-(4-methoxyphenyl)indene-1,3-dione
Canonical SMILES
COC1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
InChI
InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3
InChIKey
XRCFXMGQEVUZFC-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2197
ChEBI ID
CHEBI:133809
CAS Number
117-37-3
UNII
S747T1ERAJ
DrugBank ID
DB01125
TTD ID
D09WKB

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor IIa (F2) TT6L509 THRB_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Anisindione (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Arn-509 DMT81LZ Moderate Increased metabolism of Anisindione caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [3]
Clarithromycin DM4M1SG Major Decreased metabolism of Anisindione caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [4]
Ticarcillin DM4ME02 Moderate Increased risk of bleeding by the combination of Anisindione and Ticarcillin. Bacterial infection [1A00-1C4Z] [5]
Rabeprazole DMMZXIW Moderate Decreased metabolism of Anisindione caused by Rabeprazole mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [6]
Esterified estrogens DM9KZDO Moderate Antagonize the effect of Anisindione when combined with Esterified estrogens. Breast cancer [2C60-2C6Y] [7]
Fenofibric acid DMGO2MC Major Increased plasma concentration of Anisindione and Fenofibric acid due to competitive binding of plasma proteins. Cardiovascular disease [BA00-BE2Z] [8]
Chenodiol DMQ8JIK Moderate Increased risk of bleeding by the combination of Anisindione and Chenodiol. Cholelithiasis [DC11] [9]
Levomilnacipran DMV26S8 Moderate Increased risk of bleeding by the combination of Anisindione and Levomilnacipran. Chronic pain [MG30] [10]
Regorafenib DMHSY1I Major Increased risk of bleeding by the combination of Anisindione and Regorafenib. Colorectal cancer [2B91] [11]
Intedanib DMSTA36 Moderate Increased risk of bleeding by the combination of Anisindione and Intedanib. Colorectal cancer [2B91] [12]
Mestranol DMG3F94 Moderate Antagonize the effect of Anisindione when combined with Mestranol. Contraceptive management [QA21] [13]
Ardeparin DMYRX8B Major Increased risk of bleeding by the combination of Anisindione and Ardeparin. Coronary thrombosis [BA43] [14]
Rivaroxaban DMQMBZ1 Major Increased risk of bleeding by the combination of Anisindione and Rivaroxaban. Deep vein thrombosis [BD71] [15]
Vilazodone DM4LECQ Moderate Increased risk of bleeding by the combination of Anisindione and Vilazodone. Depression [6A70-6A7Z] [10]
Vortioxetine DM6F1PU Moderate Increased risk of bleeding by the combination of Anisindione and Vortioxetine. Depression [6A70-6A7Z] [10]
Milnacipran DMBFE74 Moderate Increased risk of bleeding by the combination of Anisindione and Milnacipran. Depression [6A70-6A7Z] [10]
Escitalopram DMFK9HG Moderate Increased risk of bleeding by the combination of Anisindione and Escitalopram. Depression [6A70-6A7Z] [10]
Desvenlafaxine DMHD4PE Moderate Increased risk of bleeding by the combination of Anisindione and Desvenlafaxine. Depression [6A70-6A7Z] [10]
Clomipramine DMINRKW Moderate Increased risk of bleeding by the combination of Anisindione and Clomipramine. Depression [6A70-6A7Z] [10]
[3H]estrone-3-sulphate DMGPF0N Moderate Antagonize the effect of Anisindione when combined with [3H]estrone-3-sulphate. Discovery agent [N.A.] [13]
Apigenin DMI3491 Minor Increased risk of bleeding by the combination of Anisindione and Apigenin. Discovery agent [N.A.] [16]
Fosphenytoin DMOX3LB Moderate Increased risk of bleeding by the combination of Anisindione and Fosphenytoin. Epilepsy/seizure [8A61-8A6Z] [17]
Phenobarbital DMXZOCG Major Increased metabolism of Anisindione caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [18]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Anisindione caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [11]
Itraconazole DMCR1MV Moderate Decreased metabolism of Anisindione caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [19]
Dexlansoprazole DM1DBV5 Moderate Decreased metabolism of Anisindione caused by Dexlansoprazole mediated inhibition of CYP450 enzyme. Gastro-oesophageal reflux disease [DA22] [6]
Avapritinib DMK2GZX Major Increased risk of bleeding by the combination of Anisindione and Avapritinib. Gastrointestinal stromal tumour [2B5B] [11]
PSI-7977 DMLSUWZ Moderate Antagonize the effect of Anisindione when combined with PSI-7977. Hepatitis virus infection [1E50-1E51] [20]
Simeprevir DMLUA9D Moderate Antagonize the effect of Anisindione when combined with Simeprevir. Hepatitis virus infection [1E50-1E51] [11]
Daclatasvir DMSFK9V Moderate Antagonize the effect of Anisindione when combined with Daclatasvir. Hepatitis virus infection [1E50-1E51] [11]
Etravirine DMGV8QU Moderate Decreased metabolism of Anisindione caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [21]
Gemfibrozil DMD8Q3J Major Increased plasma concentration of Anisindione and Gemfibrozil due to competitive binding of plasma proteins. Hyper-lipoproteinaemia [5C80] [8]
Amobarbital DM0GQ8N Major Increased metabolism of Anisindione caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [22]
Proguanil DMBL79I Moderate Decreased metabolism of Anisindione caused by Proguanil mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [23]
Calaspargase pegol DMQZBXI Moderate Increased risk of bleeding by the combination of Anisindione and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [24]
Acalabrutinib DM7GCVW Major Increased risk of bleeding by the combination of Anisindione and Acalabrutinib. Mature B-cell lymphoma [2A85] [25]
Ibrutinib DMHZCPO Major Increased risk of bleeding by the combination of Anisindione and Ibrutinib. Mature B-cell lymphoma [2A85] [20]
Ponatinib DMYGJQO Major Increased risk of bleeding by the combination of Anisindione and Ponatinib. Mature B-cell lymphoma [2A85] [26]
Panobinostat DM58WKG Major Increased risk of bleeding by the combination of Anisindione and Panobinostat. Multiple myeloma [2A83] [3]
Omacetaxine mepesuccinate DMPU2WX Major Increased risk of bleeding by the combination of Anisindione and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [27]
Prasugrel DM7MT6E Major Increased risk of bleeding by the combination of Anisindione and Prasugrel. Myocardial infarction [BA41-BA43] [11]
Vorapaxar DMA16BR Major Increased risk of bleeding by the combination of Anisindione and Vorapaxar. Myocardial infarction [BA41-BA43] [28]
Nepafenac DMYK490 Moderate Increased risk of bleeding by the combination of Anisindione and Nepafenac. Osteoarthritis [FA00-FA05] [29]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Anisindione caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [30]
MK-4827 DMLYGH4 Moderate Increased risk of bleeding by the combination of Anisindione and MK-4827. Ovarian cancer [2C73] [11]
Choline salicylate DM8P137 Moderate Increased risk of bleeding by the combination of Anisindione and Choline salicylate. Postoperative inflammation [1A00-CA43] [31]
Enzalutamide DMGL19D Moderate Increased metabolism of Anisindione caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [3]
Estramustine DMWTAOI Moderate Antagonize the effect of Anisindione when combined with Estramustine. Prostate cancer [2C82] [13]
Bicalutamide DMZMSPF Minor Increased plasma concentration of Anisindione and Bicalutamide due to competitive binding of plasma proteins. Prostate cancer [2C82] [32]
Epoprostenol DMUTYR2 Moderate Increased risk of bleeding by the combination of Anisindione and Epoprostenol. Pulmonary hypertension [BB01] [33]
Salsalate DM13P4C Moderate Increased risk of bleeding by the combination of Anisindione and Salsalate. Rheumatoid arthritis [FA20] [34]
Armodafinil DMGB035 Moderate Decreased metabolism of Anisindione caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [3]
Curcumin DMQPH29 Minor Increased risk of bleeding by the combination of Anisindione and Curcumin. Solid tumour/cancer [2A00-2F9Z] [35]
Caplacizumab DMPUKA7 Major Increased risk of bleeding by the combination of Anisindione and Caplacizumab. Thrombocytopenia [3B64] [3]
Apixaban DM89JLN Major Increased risk of bleeding by the combination of Anisindione and Apixaban. Thrombosis [DB61-GB90] [11]
Cangrelor DM8JRH0 Major Increased risk of bleeding by the combination of Anisindione and Cangrelor. Thrombosis [DB61-GB90] [36]
Brilinta DMBR01X Moderate Increased risk of bleeding by the combination of Anisindione and Brilinta. Thrombosis [DB61-GB90] [11]
Cabozantinib DMIYDT4 Major Increased risk of bleeding by the combination of Anisindione and Cabozantinib. Thyroid cancer [2D10] [37]
Lixisenatide DM0QJDC Minor Altered absorption of Anisindione due to GI dynamics variation caused by Lixisenatide. Type 2 diabetes mellitus [5A11] [3]
Betrixaban DM2C4RF Major Increased risk of bleeding by the combination of Anisindione and Betrixaban. Venous thromboembolism [BD72] [36]
Propafenone DMPIBJK Moderate Decreased metabolism of Anisindione caused by Propafenone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [38]
⏷ Show the Full List of 61 DDI Information of This Drug

References

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