Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9MPHF)

• Drug Name: 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Drug Info
• Synonyms: CHEMBL1089985; 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine; SCHEMBL2239177; 1H-Pyrrolo[2,3-b]pyridine, 4-(1H-pyrazol-4-yl)-; BDBM50315770

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 46885627
  TTD Drug ID: DM9MPHF

Molecule-Related Drug Atlas

Drug(s) Targeting Aurora B messenger RNA (AURKB mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PHA-739358	DMGYBZI	Prostate cancer	2C82.0	Phase 2	[2]
Indirubin-3'-monoxime	DMLRQH0	Discovery agent	N.A.	Investigative	[3]
SU 6656	DMF1P6W	Discovery agent	N.A.	Investigative	[4]
6-bromoindirubin-3-oxime	DM12WYV	Discovery agent	N.A.	Investigative	[3]
7-fluoroindirubin-3-oxime	DMQD34N	Discovery agent	N.A.	Investigative	[3]
PMID21742770C1	DME3JMH	Discovery agent	N.A.	Investigative	[5]
Indirubin-3-acetoxime	DM3UR1E	Discovery agent	N.A.	Investigative	[3]
CGP-57380	DMFPOUC	Discovery agent	N.A.	Investigative	[4]
PMID20855207C25	DMNEB6J	Discovery agent	N.A.	Investigative	[6]
Indirubin-3-methoxime	DMZ5ODC	Discovery agent	N.A.	Investigative	[3]

Drug(s) Targeting Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT9283	DMQ94CT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
MLN8237	DMO8PT9	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PHA-739358	DMGYBZI	Prostate cancer	2C82.0	Phase 2	[9]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
ABT-348	DMMZOYN	Haematological malignancy	2B33.Y	Phase 2	[11]
ENMD-2076	DMJZVPB	Acute myeloid leukaemia	2A60	Phase 2	[9]
LY3295668	DM8RJTB	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[12]
HPP-607	DM5VSZR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
MLN8054	DMUANF3	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
CYC116	DMUMHXT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aurora B messenger RNA (AURKB mRNA)	TT9RTBL	AURKB_HUMAN	Inhibitor	[1]
Aurora kinase A (AURKA)	TTPS3C0	AURKA_HUMAN	Inhibitor	[1]

References

• [1] Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5.
• [2] Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem. 2005 Apr 21;48(8):3080-4.
• [3] An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37.
• [4] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
• [5] A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.
• [6] Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43.
• [7] A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study. Clin Cancer Res. 2015 Jan 15;21(2):267-73.
• [8] Effect of Aurora A kinase inhibitor MLN8237 combined with rituximab on antitumor activity in preclinical B-cell non-Hodgkin's lymphoma models. Journal of Clinical Oncology, 2009:8553.
• [9] Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
• [10] A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
• [11] Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.
• [12] Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy. Mol Cancer Ther. 2019 Dec;18(12):2207-2219.
• [13] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
• [14] Clinical pipeline report, company report or official report of Cyclacel.