Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9S30P)

• Drug Name: MEMOQUIN Drug Info
• Synonyms: MEMOQUIN; 616885-87-1; SCHEMBL4365745; ZINC101086292

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9917279
  TTD Drug ID: DM9S30P

Molecule-Related Drug Atlas

Drug(s) Targeting Acetylcholinesterase (AChE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[3]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[4]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[5]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[6]
Huperzine A	DMMAWLU	Alzheimer disease	8A20	Approved	[7]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[8]
YM443	DMNZCI1	Functional dyspepsia	DD90.3	Approved	[9]
Ambenonium	DMOP0BL	Myasthenia gravis	8C6Y	Approved	[10]
Demecarium bromide	DMAYEU1	Open-angle glaucoma	9C61	Approved	[11]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[12]

Drug(s) Targeting Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hexafluronium bromide	DMFY307	Spasm	MB47.3	Approved	[13]
MEPTAZINOL	DMPSB8F	Pain	MG30-MG3Z	Approved	[14]
Eptastigmine	DMTV7ZM	Cognitive impairment	6D71	Phase 3	[15]
(-)-Phenserine	DMNCY1I	Alzheimer disease	8A20	Phase 3	[16]
Plasma derived human butyrylcholinesterase	DMF3IBC	Neurotoxicity	NE61	Phase 1	[17]
Protexia	DME1Y9W	Alzheimer disease	8A20	Phase 1	[18]
JES-9501	DMYR3IE	Alzheimer disease	8A20	Phase 1	[19]
Tetra-hydro-isoquinoline derivative 3	DMCZA45	N. A.	N. A.	Patented	[20]
Tetra-hydro-isoquinoline derivative 1	DML86IO	N. A.	N. A.	Patented	[20]
Tetra-hydro-isoquinoline derivative 2	DM5CKVF	N. A.	N. A.	Patented	[20]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[21]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[23]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[26]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[27]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[29]

Drug(s) Affected By Beta-secretase 1 (BACE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetylcholinesterase (AChE)	TT1RS9F	ACES_HUMAN	Inhibitor	[1]
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[2]
Beta-secretase 1 (BACE1)	OTCA7B6A	BACE1_HUMAN	Gene/Protein Processing	[2]

References

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