Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9WIHJ)

Drug Name

NSC-88915 Drug Info

Synonyms

3,20-dioxopregn-4-en-21-yl 4-bromobenzenesulfonate; NSC-88915; 21170-34-3; NSC88915; CHEMBL387152; AC1L60NG; AC1Q267H; SCHEMBL13856957; CTK1A5243; ZINC4901407; BDBM50158383; AKOS028112969; NCI60_041972; 170D343; 4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate); Pregn-4-ene-3,20-dione, 21-[[(4-bromophenyl)sulfonyl]oxy]-; 2-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl 4-bromobenzenesulfonate

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

PubChem CID: 259210
CAS Number: CAS 21170-34-3
TTD Drug ID: DM9WIHJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[2]
NSC-30171	DMFBZEI	Discovery agent	N.A.	Investigative	[2]
NSC-45592	DMQ6GBX	Discovery agent	N.A.	Investigative	[2]
NSC-47729	DMRZJL1	Discovery agent	N.A.	Investigative	[2]
NSC-26699	DM4RPBJ	Discovery agent	N.A.	Investigative	[2]
NSC-37173	DMZFULS	Discovery agent	N.A.	Investigative	[2]
NSC-58046	DMI6WA7	Discovery agent	N.A.	Investigative	[2]
NSC-37031	DMLY6WX	Discovery agent	N.A.	Investigative	[2]
NSC-324572	DMN50OT	Discovery agent	N.A.	Investigative	[2]
NSC-126445	DMHGIB1	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Rhodopsin (RHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[4]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[4]
Phosphonothreonine	DMTFHPI	Discovery agent	N.A.	Investigative	[4]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[4]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[4]
Lauryl Dimethylamine-N-Oxide	DM3W2OE	Discovery agent	N.A.	Investigative	[4]
B-2-Octylglucoside	DMEGX8H	Discovery agent	N.A.	Investigative	[4]
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DMY6FUD	Discovery agent	N.A.	Investigative	[4]
B-Nonylglucoside	DM48VJR	Discovery agent	N.A.	Investigative	[5]
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Drug(s) Targeting Adenylate cyclase (ADCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ad5-AC6	DMQNFZE	Cardiac failure	BD10-BD13	Terminated	[6]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[4]
N6-CYCLOPENTYLADENOSINE	DMD6AJO	Discovery agent	N.A.	Investigative	[7]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[4]
2-hydroxy-17beta-estradiol	DMM9Z0B	Discovery agent	N.A.	Investigative	[1]
2,5-didesoxy-3-ATP	DM5CWM0	Discovery agent	N.A.	Investigative	[1]
Adenosine-5'-Rp-Alpha-Thio-Triphosphate	DMKY7T8	Discovery agent	N.A.	Investigative	[8]
DEOXYADENOSINE	DMS6X1I	N. A.	N. A.	Investigative	[9]
NSC-270718	DMUNIWE	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase (ADCY)	TT2QM9D	NOUNIPROTAC	Inhibitor	[1]
Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)	TT9NVXQ	PUR9_HUMAN	Inhibitor	[2]
Rhodopsin (RHO)	TTH0KSX	OPSD_HUMAN	Inhibitor	[3]

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References

1	Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
2	Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90.
3	Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem. 2008 Sep 11;51(17):5297-303.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
7	Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
8	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
9	Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13.