Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAT2XH)

Drug Name
Nabumetone Drug Info
Synonyms NNB-001; NNB-004; NNB-005; Nabumetone (oral); Nabumetone (oral), Nobex; 6-MNA (oral), Nobex
Indication
Disease Entry ICD 11 Status REF
Osteoarthritis FA00-FA05 Approved [1]
Pain MG30-MG3Z Approved [2]
Cross-matching ID
PubChem CID
4409
ChEBI ID
CHEBI:7443
CAS Number
CAS 42924-53-8
TTD Drug ID
DMAT2XH
INTEDE Drug ID
DR1122
ACDINA Drug ID
D00451

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [12]
Naproxen DMZ5RGV Bursitis Approved [13]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [14]
Indomethacin DMSC4A7 Bursitis Approved [15]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [16]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [17]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [18]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [19]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [15]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [20]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [21]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [30]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [37]
Estrone DM5T6US Acne vulgaris ED80 Approved [38]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
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Drug(s) Metabolized By Aldo-keto reductase 1C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [40]
FENOFIBRIC ACID DMGO2MC Cardiovascular disease BA00-BE2Z Approved [41]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [40]
Trastuzumab emtansine DMU1LXS HER2-positive breast cancer 2C60-2C65 Phase 2 [42]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [43]
Drug(s) Metabolized By Aldo-keto reductase 1C4 (AKR1C4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Norethindrone acetate DMDGCQP N. A. N. A. Approved [44]
Trastuzumab emtansine DMU1LXS HER2-positive breast cancer 2C60-2C65 Phase 2 [42]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [43]
Drug(s) Metabolized By Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cortisone Acetate DMG8K57 Acne vulgaris ED80 Approved [45]
Dehydrocorticosterone DM48KMB N. A. N. A. Investigative [45]
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [9]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [9]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [48]
Etidronic acid DM1XHYJ Bone Paget disease Approved [9]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [9]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [49]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [50]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [52]
Verapamil DMA7PEW Angina pectoris BA40 Approved [10]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [53]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [10]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [57]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [59]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [60]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [62]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Verapamil DMA7PEW Angina pectoris BA40 Approved [65]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [66]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [68]
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Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [8]
Meloxicam DM2AR7L Arthritis FA20 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [8]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [72]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [73]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [5]
Aldo-keto reductase 1C1 (AKR1C1) DE7P2FB AK1C1_HUMAN Substrate [6]
Aldo-keto reductase 1C4 (AKR1C4) DEAJN47 AK1C4_HUMAN Substrate [6]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DEZDRQO DHI1_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [7]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Gene/Protein Processing [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [9]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [10]
Utrophin OT7TZ637 UTRN_HUMAN Gene/Protein Processing [11]

References

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