Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB6FMH)

Drug Name

BMTP-11 Drug Info

Synonyms

IL-11Ralpha targeted proapoptotic peptide (prostate cancer), MD Anderson Cancer Center; IL-11Ralpha targeted proapoptotic peptide (prostate cancer), Mercator

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMB6FMH

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Interleukin 11 receptor alpha (IL11RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oprelvekin	DMTSRI6	Inflammatory bowel disease	DD72	Approved	[3]
UNI-rhIL-11	DM0DIEZ	Thrombocytopenia	3B64	Phase 3	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 11 receptor alpha (IL11RA)	TTZPLJS	I11RA_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00872157) BMTP-11 in Patients With Castrate-Resistant Prostate Cancer With Bone Mets. U.S. National Institutes of Health.
2	Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens. Clin Cancer Res. 2015 Jul 1;21(13):3041-51.
3	Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71.
4	Clinical study of rhIL-11 for prevention and treatment of chemotherapy-induced thrombocytopenia. Ai Zheng. 2002 Aug;21(8):892-5.