Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBW208)

Drug Name
Pyrrolo-pyrrolone derivative 6 Drug Info
Synonyms PMID26924192-Compound-39
Cross-matching ID
PubChem CID
122553484
TTD Drug ID
DMBW208

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
C 82 DMEWXFK Scleroderma 4A42 Phase 1/2 [2]
CCS1477 DM9UZM1 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [3]
PRI-724 DM0HTEF Acute myeloid leukaemia 2A60 Phase 1/2 [4]
FT-7051 DMCK3OI Prostate cancer 2C82.0 Phase 1 [5]
SGC-CBP30 DMTLRGZ Discovery agent N.A. Investigative [6]
I-CBP112 DMQX3W6 Discovery agent N.A. Investigative [7]
ischemin DMM2I9G Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CREB-binding protein (CREBBP) TTFRCTK CBP_HUMAN Inhibitor [1]

References

1 BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1118-1137.
4 Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14309-14.
5 Clinical pipeline report, company report or official report of FORMA Therapeutics.
6 Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2734).
8 A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41.