Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC7YQE)

Drug Name

SM-122 Drug Info

Synonyms

SM-122; CHEMBL481422; Smac peptide mimetic 20; GTPL8855; SCHEMBL12105346; BDBM26218; bicyclic Smac peptide mimetic, 20; (3S,6S,10aS)-N-benzhydryl-6-[[(2S)-2-(methylamino)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 24754886
TTD Drug ID: DMC7YQE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Apoptosis-2 messenger RNA (BIRC3 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SM-337	DMOSTP9	Discovery agent	N.A.	Investigative	[1]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[2]
ISIS 23452	DM17G39	Discovery agent	N.A.	Investigative	[3]
ISIS 23454	DM7FPZV	Discovery agent	N.A.	Investigative	[3]
ISIS 23459	DM4PGRU	Discovery agent	N.A.	Investigative	[3]
ISIS 23414	DMOC0DT	Discovery agent	N.A.	Investigative	[3]
ISIS 23416	DMHQD76	Discovery agent	N.A.	Investigative	[3]
ISIS 23412	DMJ0LB1	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting XIAP messenger RNA (XIAP mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASTX660	DMMKW8L	Lymphoma	2A80-2A86	Phase 2	[4]
AEG35156	DM2HRYD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
EMBELIN	DMFZO4Y	N. A.	N. A.	Terminated	[6]
AZD5582	DMPIHN6	Discovery agent	N.A.	Investigative	[7]
SM-337	DMOSTP9	Discovery agent	N.A.	Investigative	[1]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[2]
BV-6	DMDTV7A	Discovery agent	N.A.	Investigative	[8]
ARPFAQK-FAM	DMU70YP	Discovery agent	N.A.	Investigative	[6]
AVPIAQKSEK-FAM	DMNQ9R4	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis-2 messenger RNA (BIRC3 mRNA)	TTAIWZN	BIRC3_HUMAN	Inhibitor	[1]
XIAP messenger RNA (XIAP mRNA)	TTK3WBU	XIAP_HUMAN	Inhibitor	[1]

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References

1	Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7.
2	Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5.
3	US patent application no. 5,958,771, Antisense modulation of cellular inhibitor of Apoptosis-2 expression.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6.
6	Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40.
7	Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
8	IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.