Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCA9QP)

Drug Name
Papaverine Drug Info
Synonyms
papaverine; Papaverin; Papanerine; Robaxapap; 58-74-2; Papanerin; Pavabid; Papaverina; Pavatym; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline; Cerespan; Papaverine [BAN]; Pavacot; Papaverina [Italian]; 6,7-Dimethoxy-1-veratrylisoquinoline; Papaverine Hcl; NSC 136630; UNII-DAA13NKG2Q; Isoquinoline, 6,7-dimethoxy-1-veratryl-; S-M-R; Papaverine (BAN); Pamelon; Chlorhydrate de papaverine; Qua bid; 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-isoquinoline; 1-((3,4-Dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline; Alapav; Cardiospan; Cardoverina; Ceraspan; Cerebid; Delapav; Dilaves; Dispamil; Drapavel; Durapav; Dynovas; Forpavin; Genabid; Mesotina; Myobid; Pameion; Panergon; Papacon; Papalease; Papaversan; Pavacap; Pavacels; Pavacen; Pavagen; Pavarine; Pavatest; Pavatine; Paverolan; Paveron; Pavnell; Vasal; PAP H; Papavarine chlorhydrate; Papaverine chlorohydrate; Papaverine monohydrochloride; Papaverinium chloride; Pavabid Hp; RS 47; TNP00305; Alapav (TN); Albatran (TN); Artegodan (TN); Cardiospan (TN); Cardioverina (TN); Cepaverin (TN); Cerebid (TN); Cerespan (TN); Delapav (TN); Dicertan (TN); Dilaves (TN); Dispamil (TN); Drapavel (TN); Durapav (TN); Dynovas (TN); Forpaven (TN); Houde (TN); Mesotina (TN); Myobid (TN); Opdensit (TN); Optenyl (TN); Pameion (TN); Pamelon (TN); Panergon (TN); Papacon (TN); Papalease (TN); Papanerin-hcl; Papaversan (TN); Pavabid (TN); Pavacap (TN); Pavacen (TN); Pavadel (TN); Pavadyl (TN); Pavagen (TN); Pavakey (TN); Pavased (TN); Pavatest (TN); Paverina (TN); Paverolan (TN); Paveron (TN); Pavnell (TN); Qua bid (TN); Ro-Papav; Therapav (TN); Vasal (TN); Vaso-Pav; Vasospan (TN); Papanerin-hcl (TN); Papaverin-Hamelin (TN); Papital TR; Paptial TR; Ro-Papav (TN); Spasmo-Nit (TN); Vaso-Pav (TN); Pap-Kaps-150 (TN); Papital TR (TN); Paptial TR (TN); Isoquinoline,6,7-dimethoxy-1-veratryl-(8CI); Isoquinoline, 6,7-dimethoxy-1-veratryl-(8Cl); 1-[(3,4-Dimethoxyphenyl)methyl]6,7-dimethoxyisoquinoline; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline; 1-{[3,4-bis(methyloxy)phenyl]methyl}-6,7-bis(methyloxy)isoquinoline; 4-[(6,7-Dimethoxyisoquinolyl)methyl]-1,2-dimethoxybenzene; 6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline; 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE
Indication
Disease Entry ICD 11 Status REF
Brain ischaemia 8B1Z Approved [1]
Spasm MB47.3 Approved [2]
Peripheral vascular disease BD4Z Investigative [3]
Therapeutic Class
Vasodilator Agents
Cross-matching ID
PubChem CID
4680
ChEBI ID
CHEBI:28241
CAS Number
CAS 58-74-2
TTD Drug ID
DMCA9QP
VARIDT Drug ID
DR00967
INTEDE Drug ID
DR2299

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Phosphodiesterase 4D (PDE4D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DENBUFYLLINE DM2R15Q Cognitive impairment 6D71 Phase 3 [11]
SOTB07 DMIG4OX Asthma CA23 Phase 3 [12]
AN-2898 DMDK7CL Atopic dermatitis EA80 Phase 2 [13]
GPD-1116 DMOQ7YI Asthma CA23 Phase 2 [14]
TA-7906 DMZTAJL Atopic dermatitis EA80 Phase 2 [15]
HT-0712 DM2WP8F Cognitive impairment 6D71 Phase 2 [12]
TOFIMILAST DMLCUAS Chronic obstructive pulmonary disease CA22 Phase 2 [16]
AWD-12-281 DMVADGZ Rhinitis FA20 Phase 2 [17]
LIRIMILAST DMD4KAU Chronic obstructive pulmonary disease CA22 Phase 2 [16]
Oglemilast DMVC90W Asthma CA23 Phase 2 [18]
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Drug(s) Targeting Phosphodiesterase 5A (PDE5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tadalafil DMJZHT1 Benign prostatic hyperplasia GA90 Approved [19]
Udenafil DM1IQRP Erectile dysfunction HA01.1 Approved [20]
Vardenafil DMTBGW8 Cystic fibrosis CA25 Approved [21]
Dipyridamole DMXY30O Atrial fibrillation BC81.3 Approved [22]
Avanafil DM75CXN Erectile dysfunction HA01.1 Approved [16]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [23]
ICARIIN DMOJQGT N. A. N. A. Phase 3 [24]
EXISULIND DMBY56U Colorectal cancer 2B91.Z Phase 3 [25]
PF-489791 DM3C8GQ Chronic obstructive pulmonary disease CA22 Phase 2 [26]
UK-371800 DMI8795 Erectile dysfunction HA01.1 Phase 1 [27]
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Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [6]
Diazepam DM08E9O Alcohol withdrawal Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [29]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [6]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [6]
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Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [31]
Miglustat DM5J64S Niemann-Pick disease type C Approved [32]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [33]
Milrinone DM8TUPF Congestive heart failure BD10 Approved [8]
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [34]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [34]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
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Drug(s) Affected By Hepcidin (HAMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [10]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Ethanol DMDRQZU Chronic pain MG30 Approved [42]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [10]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [9]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [44]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [45]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [9]
Ethacrynic acid DM60QMR Edema MG29 Approved [9]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [9]
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Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [47]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [50]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [47]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [48]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [7]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [51]
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Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [52]
Diazepam DM08E9O Alcohol withdrawal Approved [6]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [6]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [6]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [6]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [6]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [6]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [6]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [6]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 4D (PDE4D) TTSKMI8 PDE4D_HUMAN Inhibitor [4]
Phosphodiesterase 5A (PDE5A) TTJ0IQB PDE5A_HUMAN Inhibitor [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [6]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Gene/Protein Processing [7]
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Gene/Protein Processing [8]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [9]
Hepcidin (HAMP) OT607RBL HEPC_HUMAN Gene/Protein Processing [10]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Gene/Protein Processing [6]

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