Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCKYZ5)

Drug Name
Clenbuterol Drug Info
Synonyms
Clenbuterolum; Contraspasmin; Planipart; Planipart [veterinary]; Clenbuterol (INN); Clenbuterol [BAN:INN]; Clenbuterolum [INN-Latin]; Contraspasmin (TN); NAB-365; Planipart [veterinary] (TN); (+)-4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol; (+-)-clenbuterol; (-)-4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol; 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanol; 1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol; 1-(4-amino-3,5-dichlorophenyl)-2-[(1,1-dimethylethyl)amino]ethanol; 4-Amino-3,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol; 4-Amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol
Indication
Disease Entry ICD 11 Status REF
Chronic breathing disorder 7A4Z Approved [1]
Therapeutic Class
Bronchodilator Agents
Cross-matching ID
PubChem CID
2783
ChEBI ID
CHEBI:174690
CAS Number
CAS 37148-27-9
TTD Drug ID
DMCKYZ5
INTEDE Drug ID
DR0338

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor beta-2 (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indacaterol DMQJHR7 Chronic obstructive pulmonary disease CA22 Approved [5]
Formoterol DMSOURV Allergic asthma CA23.0 Approved [6]
Salbutamol DMN9CWF Acute asthma CA23 Approved [7]
Arformoterol DMYM974 Chronic obstructive pulmonary disease CA22 Approved [8]
Isoproterenol DMK7MEY Atrioventricular block Approved [9]
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [10]
Ritodrine DM4V6RL Premature labour JB00 Approved [11]
Olodaterol DM62B78 Chronic obstructive pulmonary disease CA22 Approved [12]
Fenoterol DMIP3ZV Asthma CA23 Approved [13]
Vilanterol DMF5EK1 Chronic obstructive pulmonary disease CA22 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [15]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [16]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [22]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [29]
Estrone DM5T6US Acne vulgaris ED80 Approved [30]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [31]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [32]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [33]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [34]
Bambuterol DMKLSHF Asthma CA23 Approved [4]
Terbutaline DMD4381 Asthma CA23 Approved [35]
Salbutamol DMN9CWF Acute asthma CA23 Approved [36]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Epinephrine DM3KJBC Acute asthma CA23 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [41]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [42]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-2 (ADRB2) TT2CJVK ADRB2_HUMAN Agonist [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [3]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Gene/Protein Processing [4]

References

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27 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94.
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35 Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. Pediatr Crit Care Med. 2006 Jan;7(1):15-8. doi: 10.1097/01.pcc.0000194010.63115.a2.
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37 Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome. Eur J Pharmacol. 1999 Dec 15;386(2-3):135-44. doi: 10.1016/s0014-2999(99)00749-9.
38 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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