Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCRFT5)

Drug Name

UC-1011 Drug Info

Synonyms

UC-2021; UC-2025; GABA A receptor antagonists (Alzheimer's disease); GABA A receptor antagonists (Alzheimer's disease), Umecrine; 3beta-20beta-dihydroxy-5alpha-pregnane; 3beta-20beta-dihydroxy-5alpha-pregnane (Alzheimer's disease), Umecrine

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMCRFT5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[1]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[2]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[3]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[1]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[4]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[3]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[2]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[3]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[3]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Antagonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.