Details of the Drug

General Information of Drug (ID: DMW1OQ0)

Drug Name
Clobazam - Lundbeck
Synonyms
Clobazam; Chlorepin; Urbanyl; Frisium; Clorepin; Urbadan; 22316-47-8; Clobazamum; Onfi; LM-2717; HR 376; RU-4723; Clobazamum [INN-Latin]; LM 2717; H-4723; H 4723; 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione; UNII-2MRO291B4U; 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl-; NSC 336279; 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine; CCRIS 7506; 7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione; EINECS 244-908-7; BRN 0758410; Onfi
Indication
Disease Entry ICD 11 Status REF
Anxiety disorder 6B00-6B0Z Approved [1]
Epilepsy 8A60-8A68 Approved [1]
Therapeutic Class
Neurology Agents
Affected Organisms
Humans and other mammals
ATC Code
N05BA09: Clobazam - Lundbeck
N05BA: Benzodiazepine derivatives
N05B: ANXIOLYTICS
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 300.74
Logarithm of the Partition Coefficient (xlogp) 2.1
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 2
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [2]
Bioavailability
90% of drug becomes completely available to its intended biological destination(s) [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 32 hours (an oral dose of 40 mg) [4]
Metabolism
The drug is metabolized via the liver []
Vd
The volume of distribution (Vd) of drug is 100 L []
Water Solubility
The ability of drug to dissolve in water is measured as 0.188 mg/mL [2]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Metabolic disorder rs4244285 CYP2C19 OTFMJYYE [5]
Parapsoriasis rs7412 APOE OTFOWL2H [6]
Chemical Identifiers
Formula
C16H13ClN2O2
IUPAC Name
7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione
Canonical SMILES
CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
InChIKey
CXOXHMZGEKVPMT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2789
ChEBI ID
CHEBI:31413
CAS Number
22316-47-8
UNII
2MRO291B4U
DrugBank ID
DB00349
TTD ID
D0S9MC
VARIDT ID
DR01295
INTEDE ID
DR0342
ACDINA ID
D00137
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Antagonist [7]
GABA(A) receptor gamma-3 (GABRG3) TTEX6LM GBRG3_HUMAN Modulator [8]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [5]
Mephenytoin 4-hydroxylase (CYP2C19)
Main DME 		DEGTFWK CP2CJ_HUMAN Substrate [10]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [5]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Drug Response [6]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Drug Response [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Anxiety disorder
ICD Disease Classification 6B00-6B0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
GABA(A) receptor alpha-1 (GABRA1) DTT GABRA1 9.57E-01 -0.12 -0.18
P-glycoprotein 1 (ABCB1) DTP P-GP 7.83E-01 4.69E-02 1.89E-01
Cytochrome P450 2C18 (CYP2C18) DME CYP2C18 7.90E-01 3.72E-02 2.95E-01
Cytochrome P450 2B6 (CYP2B6) DME CYP2B6 5.79E-01 -1.30E-02 -9.78E-02
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 7.66E-01 9.19E-03 4.88E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 6.06E-01 -2.42E-02 -1.64E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Clobazam - Lundbeck (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sodium bicarbonate DMMU6BJ Minor Altered absorption of Clobazam - Lundbeck due to GI dynamics variation caused by Sodium bicarbonate. Acidosis [5C73] [11]
Arn-509 DMT81LZ Moderate Increased metabolism of Clobazam - Lundbeck caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [12]
Oliceridine DM6MDCF Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Oliceridine. Acute pain [MG31] [13]
Emapalumab DMZG5WL Moderate Altered metabolism of Clobazam - Lundbeck due to Emapalumab alters the formation of CYP450 enzymes. Adaptive immunity immunodeficiency [4A01] [12]
Galantamine DMEO794 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Galantamine mediated inhibition of CYP450 enzyme. Alzheimer disease [8A20] [14]
Donepezil DMIYG7Z Minor Decreased metabolism of Clobazam - Lundbeck caused by Donepezil mediated inhibition of CYP450 enzyme. Alzheimer disease [8A20] [15]
Siltuximab DMGEATB Moderate Altered metabolism of Clobazam - Lundbeck due to Siltuximab alters the formation of CYP450 enzymes. Anemia [3A00-3A9Z] [12]
Voriconazole DMAOL2S Moderate Decreased metabolism of Clobazam - Lundbeck caused by Voriconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [14]
Desipramine DMT2FDC Moderate Decreased metabolism of Clobazam - Lundbeck caused by Desipramine mediated inhibition of CYP450 enzyme. Attention deficit hyperactivity disorder [6A05] [14]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Clobazam - Lundbeck caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [16]
Clarithromycin DM4M1SG Moderate Decreased metabolism of Clobazam - Lundbeck caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [17]
Chloramphenicol DMFXEWT Moderate Decreased metabolism of Clobazam - Lundbeck caused by Chloramphenicol mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [14]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Clobazam - Lundbeck caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [17]
Pexidartinib DMS2J0Z Moderate Decreased metabolism of Clobazam - Lundbeck caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [14]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Clobazam - Lundbeck caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [18]
Letrozole DMH07Y3 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Letrozole mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [14]
Grepafloxacin DMGLX0T Moderate Decreased metabolism of Clobazam - Lundbeck caused by Grepafloxacin mediated inhibition of CYP450 enzyme. Bronchitis [CA20] [19]
Dihydrocodeine DMB0FWL Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Dihydrocodeine. Chronic pain [MG30] [20]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Olopatadine. Conjunctiva disorder [9A60] [21]
Drospirenone DM1A9W3 Moderate Increased metabolism of Clobazam - Lundbeck caused by Drospirenone mediated induction of CYP450 enzyme. Contraceptive management [QA21] [22]
Levonorgestrel DM1DP7T Moderate Increased metabolism of Clobazam - Lundbeck caused by Levonorgestrel mediated induction of CYP450 enzyme. Contraceptive management [QA21] [22]
Norgestimate DMYP4XC Moderate Increased metabolism of Clobazam - Lundbeck caused by Norgestimate mediated induction of CYP450 enzyme. Contraceptive management [QA21] [23]
Propofol DMB4OLE Moderate Additive cardiorespiratory depression effects by the combination of Clobazam - Lundbeck and Propofol. Corneal disease [9A76-9A78] [24]
Alfentanil DMVO0UB Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Alfentanil. Corneal disease [9A76-9A78] [13]
Remifentanil DMZTXCH Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Remifentanil. Corneal disease [9A76-9A78] [13]
Dextromethorphan DMUDJZM Moderate Decreased metabolism of Clobazam - Lundbeck caused by Dextromethorphan mediated inhibition of CYP450 enzyme. Cough [MD12] [14]
Osilodrostat DMIJC9X Moderate Decreased metabolism of Clobazam - Lundbeck caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [14]
Lumacaftor DMCLWDJ Moderate Increased metabolism of Clobazam - Lundbeck caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [25]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Ethanol. Cystitis [GC00] [26]
MK-8228 DMOB58Q Moderate Increased metabolism of Clobazam - Lundbeck caused by MK-8228 mediated induction of CYP450 enzyme. Cytomegaloviral disease [1D82] [27]
Aprepitant DM053KT Moderate Decreased metabolism of Clobazam - Lundbeck caused by Aprepitant mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [28]
Trimipramine DM1SC8M Moderate Decreased metabolism of Clobazam - Lundbeck caused by Trimipramine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Imipramine DM2NUH3 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Imipramine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Fluoxetine DM3PD2C Moderate Decreased metabolism of Clobazam - Lundbeck caused by Fluoxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Clobazam - Lundbeck caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Paroxetine DM5PVQE Moderate Decreased metabolism of Clobazam - Lundbeck caused by Paroxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Duloxetine DM9BI7M Moderate Decreased metabolism of Clobazam - Lundbeck caused by Duloxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [30]
OPC-34712 DMHG57U Major Decreased metabolism of Clobazam - Lundbeck caused by OPC-34712 mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [31]
Clomipramine DMINRKW Moderate Decreased metabolism of Clobazam - Lundbeck caused by Clomipramine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Doxepin DMPI98T Moderate Decreased metabolism of Clobazam - Lundbeck caused by Doxepin mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Maprotiline DMPWB7T Moderate Decreased metabolism of Clobazam - Lundbeck caused by Maprotiline mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [14]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Esketamine. Depression [6A70-6A7Z] [32]
SODIUM CITRATE DMHPD2Y Minor Altered absorption of Clobazam - Lundbeck due to GI dynamics variation caused by SODIUM CITRATE. Discovery agent [N.A.] [11]
Tetrabenazine DMYWQ0O Moderate Decreased metabolism of Clobazam - Lundbeck caused by Tetrabenazine mediated inhibition of CYP450 enzyme. Dissociative neurological symptom disorder [6B60] [14]
Fenfluramine DM0762O Moderate Decreased metabolism of Clobazam - Lundbeck caused by Fenfluramine mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [12]
Mephenytoin DM5UGDK Moderate Increased metabolism of Clobazam - Lundbeck caused by Mephenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Cenobamate DM8KLU9 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Cenobamate mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [14]
Stiripentol DMMSDOY Moderate Decreased metabolism of Clobazam - Lundbeck caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [34]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Clobazam - Lundbeck caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Rufinamide DMWE60C Moderate Increased metabolism of Clobazam - Lundbeck caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [12]
Cannabidiol DM0659E Moderate Decreased metabolism of Clobazam - Lundbeck caused by Cannabidiol mediated inhibition of CYP450 enzyme. Epileptic encephalopathy [8A62] [35]
Timolol DM3NXRU Moderate Decreased metabolism of Clobazam - Lundbeck caused by Timolol mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [36]
Tolterodine DMSHPW8 Minor Decreased metabolism of Clobazam - Lundbeck caused by Tolterodine mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [37]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Clobazam - Lundbeck caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [38]
Ketoconazole DMPZI3Q Moderate Decreased metabolism of Clobazam - Lundbeck caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [14]
Cimetidine DMH61ZB Moderate Decreased metabolism of Clobazam - Lundbeck caused by Cimetidine mediated inhibition of CYP450 enzyme. Gastro-oesophageal reflux disease [DA22] [39]
Brimonidine DMQLT4N Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Brimonidine. Glaucoma [9C61] [40]
Digoxin DMQCTIH Moderate Increased plasma concentration of Clobazam - Lundbeck and Digoxin due to competitive binding of plasma proteins. Heart failure [BD10-BD1Z] [41]
Isoniazid DM5JVS3 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Isoniazid mediated inhibition of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [42]
Rifampin DMA8J1G Minor Increased metabolism of Clobazam - Lundbeck caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [43]
Delavirdine DM3NF5G Minor Decreased metabolism of Clobazam - Lundbeck caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [44]
Fosamprenavir DM4W9B3 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [45]
Efavirenz DMC0GSJ Moderate Decreased metabolism of Clobazam - Lundbeck caused by Efavirenz mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [14]
Etravirine DMGV8QU Moderate Decreased metabolism of Clobazam - Lundbeck caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [14]
Didanosine DMI2QPE Minor Altered absorption of Clobazam - Lundbeck due to GI dynamics variation caused by Didanosine. Human immunodeficiency virus disease [1C60-1C62] [11]
Amprenavir DMLMXE0 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [45]
Ritonavir DMU764S Moderate Decreased metabolism of Clobazam - Lundbeck caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [46]
Fenofibrate DMFKXDY Moderate Decreased metabolism of Clobazam - Lundbeck caused by Fenofibrate mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [14]
Probenecid DMMFWOJ Minor Decreased metabolism of Clobazam - Lundbeck caused by Probenecid. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [47]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Clobazam - Lundbeck caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [12]
Ethinyl estradiol DMODJ40 Moderate Increased metabolism of Clobazam - Lundbeck caused by Ethinyl estradiol mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [23]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [48]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Lasmiditan. Migraine [8A80] [49]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Flibanserin. Mood disorder [6A60-6E23] [50]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Thalidomide. Multiple myeloma [2A83] [51]
Rifabutin DM1YBHK Minor Increased metabolism of Clobazam - Lundbeck caused by Rifabutin mediated induction of CYP450 enzyme. Mycobacterium infection [1B10-1B21] [43]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [14]
Nilotinib DM7HXWT Moderate Decreased metabolism of Clobazam - Lundbeck caused by Nilotinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [52]
Imatinib DM7RJXL Moderate Decreased metabolism of Clobazam - Lundbeck caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [53]
Modafinil DMYILBE Moderate Decreased metabolism of Clobazam - Lundbeck caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [14]
Droperidol DM0DXA8 Major Increased risk of prolong QT interval by the combination of Clobazam - Lundbeck and Droperidol. Nausea/vomiting [MD90] [54]
Prochlorperazine DM53SRA Moderate Decreased metabolism of Clobazam - Lundbeck caused by Prochlorperazine mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [14]
Promethazine DM6I5GR Moderate Decreased metabolism of Clobazam - Lundbeck caused by Promethazine mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [14]
Metoclopramide DMFA5MY Moderate Decreased metabolism of Clobazam - Lundbeck caused by Metoclopramide mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [14]
Teduglutide DMYOAKS Moderate Altered absorption of Clobazam - Lundbeck caused by Teduglutide. Neonatal malabsorption syndrome [KB89] [55]
Dexfenfluramine DMJ7YDS Moderate Decreased metabolism of Clobazam - Lundbeck caused by Dexfenfluramine mediated inhibition of CYP450 enzyme. Obesity [5B80-5B81] [14]
Levomethadyl Acetate DM06HG5 Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Levomethadyl Acetate. Opioid use disorder [6C43] [20]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Apraclonidine. Optic nerve disorder [9C40] [40]
Pentazocine DM1XBHS Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Pentazocine. Pain [MG30-MG3Z] [13]
Dextropropoxyphene DM23HCX Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Dextropropoxyphene. Pain [MG30-MG3Z] [56]
Butorphanol DM5KYPJ Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Butorphanol. Pain [MG30-MG3Z] [13]
Oxymorphone DM65AGJ Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Oxymorphone. Pain [MG30-MG3Z] [13]
Levorphanol DMGS80V Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Levorphanol. Pain [MG30-MG3Z] [13]
Dezocine DMJDB0Y Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Dezocine. Pain [MG30-MG3Z] [13]
Nalbuphine DMOSQGU Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Nalbuphine. Pain [MG30-MG3Z] [13]
Methamphetamine DMPM4SK Moderate Decreased metabolism of Clobazam - Lundbeck caused by Methamphetamine mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [57]
Buprenorphine DMPRI8G Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Buprenorphine. Pain [MG30-MG3Z] [58]
Hydrocodone DMQ2JO5 Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Hydrocodone. Pain [MG30-MG3Z] [13]
Meperidine DMX4GND Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Meperidine. Pain [MG30-MG3Z] [13]
Oxycodone DMXLKHV Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Oxycodone. Pain [MG30-MG3Z] [13]
Abametapir DM2RX0I Moderate Decreased metabolism of Clobazam - Lundbeck caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [59]
Esomeprazole DM7BN0X Moderate Decreased metabolism of Clobazam - Lundbeck caused by Esomeprazole mediated inhibition of CYP450 enzyme. Peptic ulcer [DA61] [14]
Lefamulin DME6G97 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [57]
Lonafarnib DMGM2Z6 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [14]
Enzalutamide DMGL19D Moderate Increased metabolism of Clobazam - Lundbeck caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [60]
Tamsulosin DM5QF9V Moderate Decreased metabolism of Clobazam - Lundbeck caused by Tamsulosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [61]
Ustekinumab DMHTYK3 Moderate Altered metabolism of Clobazam - Lundbeck due to Ustekinumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [12]
Ixekizumab DMXW92T Moderate Altered metabolism of Clobazam - Lundbeck due to Ixekizumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [12]
Levomepromazine DMIKFEL Moderate Decreased metabolism of Clobazam - Lundbeck caused by Levomepromazine mediated inhibition of CYP450 enzyme. Psychotic disorder [6A20-6A25] [14]
Fluphenazine DMIT8LX Moderate Decreased metabolism of Clobazam - Lundbeck caused by Fluphenazine mediated inhibition of CYP450 enzyme. Psychotic disorder [6A20-6A25] [14]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Clobazam - Lundbeck and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [62]
Tocilizumab DM7J6OR Moderate Altered metabolism of Clobazam - Lundbeck due to Tocilizumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [12]
Canakinumab DM8HLO5 Moderate Altered metabolism of Clobazam - Lundbeck due to Canakinumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [12]
Rilonacept DMGLUQS Moderate Altered metabolism of Clobazam - Lundbeck due to Rilonacept alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [12]
Golimumab DMHZV7X Moderate Altered metabolism of Clobazam - Lundbeck due to Golimumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [12]
Sarilumab DMOGNXY Moderate Altered metabolism of Clobazam - Lundbeck due to Sarilumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [12]
Thioridazine DM35M8J Major Decreased metabolism of Clobazam - Lundbeck caused by Thioridazine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [63]
Aripiprazole DM3NUMH Moderate Decreased metabolism of Clobazam - Lundbeck caused by Aripiprazole mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [64]
Iloperidone DM6AUFY Moderate Decreased metabolism of Clobazam - Lundbeck caused by Iloperidone mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [14]
Haloperidol DM96SE0 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Haloperidol mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [14]
Perphenazine DMA4MRX Moderate Decreased metabolism of Clobazam - Lundbeck caused by Perphenazine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [14]
Chlorpromazine DMBGZI3 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Chlorpromazine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [14]
Risperidone DMN6DXL Moderate Decreased metabolism of Clobazam - Lundbeck caused by Risperidone mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [14]
Pimozide DMW83TP Moderate Decreased metabolism of Clobazam - Lundbeck caused by Pimozide mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [14]
Fentanyl DM8WAHT Major Additive CNS depression effects by the combination of Clobazam - Lundbeck and Fentanyl. Sensation disturbance [MB40] [13]
Armodafinil DMGB035 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [14]
Norethindrone DMTY169 Moderate Increased metabolism of Clobazam - Lundbeck caused by Norethindrone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [23]
Fostamatinib DM6AUHV Moderate Decreased clearance of Clobazam - Lundbeck due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [65]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Clobazam - Lundbeck and Tizanidine. Tonus and reflex abnormality [MB47] [66]
Sirolimus DMGW1ID Moderate Increased plasma concentrations of Clobazam - Lundbeck and Sirolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [62]
Tacrolimus DMZ7XNQ Moderate Increased plasma concentrations of Clobazam - Lundbeck and Tacrolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [62]
Chlorpheniramine DM5URA2 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Chlorpheniramine mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [14]
Mexiletine DMCTE9R Moderate Decreased metabolism of Clobazam - Lundbeck caused by Mexiletine mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [14]
Propafenone DMPIBJK Moderate Decreased metabolism of Clobazam - Lundbeck caused by Propafenone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [14]
Amiodarone DMUTEX3 Moderate Decreased metabolism of Clobazam - Lundbeck caused by Amiodarone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [14]
⏷ Show the Full List of 135 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Clobazam 10 mg tablet 10 mg Oral Tablet Oral
Clobazam 20 mg tablet 20 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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