Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDF79Z)

Drug Name
Acetylcholine Drug Info
Synonyms
acetylcholine; Choline acetate; O-Acetylcholine; Acetyl choline ion; Acetylcholinum; 51-84-3; (2-Acetoxyethyl)trimethylammonium; Acetyl choline cation; Choline acetate (ester); 2-(Acetyloxy)-N,N,N-trimethylethanaminium; Ach; Azetylcholin; ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-; UNII-N9YNS0M02X; BRN 1764436; CHEBI:15355; Bromoacetylcholine; EINECS 200-128-9; CHEMBL667; N9YNS0M02X; [2-(acetyloxy)ethyl]trimethylazanium; Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl- (9CI); 2-acetyloxyethyl-trimethylazanium; [3H]acetylcholine; Miochol; Miochol-e
Indication
Disease Entry ICD 11 Status REF
Cataract 9B10 Approved [1]
Therapeutic Class
Cardiovascular Agents
Cross-matching ID
PubChem CID
187
ChEBI ID
CHEMBL667
CAS Number
CAS 51-84-3
TTD Drug ID
DMDF79Z
VARIDT Drug ID
DR00070
INTEDE Drug ID
DR0041

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor (CHRM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [10]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [11]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [12]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [13]
Oxybutynin hydrochloride DMF2KLU Urinary incontinence MF50.2 Approved [14]
Incruse Ellipta DM32GSJ Chronic obstructive pulmonary disease CA22 Approved [15]
Revefenacin DMMP5SI Chronic obstructive pulmonary disease CA22 Approved [16]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [17]
Isopropamide iodide DMQYV60 Allergic rhinitis CA08.0 Approved [18]
SUN-101 DMXNZQK Chronic obstructive pulmonary disease CA22 Phase 3 [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [21]
Metformin DM89QE1 Colorectal carcinoma Approved [22]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [20]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [23]
Epinephrine DM3KJBC Acute asthma CA23 Approved [21]
Norepinephrine DMOUC09 Alopecia ED70 Approved [21]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [24]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [25]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [32]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [33]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [34]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [35]
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Choline transporter-like protein 4 (SLC44A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin B1 DMZ1WXJ Vitamin B1 deficiency 5B5A Approved [36]
CHOLINE DM5D9YK Insomnia 7A00-7A0Z Investigative [37]
Drug(s) Metabolized By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [38]
Drug(s) Affected By Secreted Ly-6/uPAR-related protein 1 (SLURP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [39]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [40]
Drug(s) Affected By Interleukin-5 receptor subunit alpha (IL5RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Isoproterenol DMK7MEY Atrioventricular block Approved [42]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [43]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [40]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [44]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor (CHRM) TTOXS3C NOUNIPROTAC Agonist [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Choline transporter-like protein 4 (SLC44A4) DT8KXR9 CTL4_HUMAN Substrate [3]
Vesicular acetylcholine transporter (SLC18A3) DT3T2K0 VACHT_HUMAN Substrate [4]
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [5]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Acetylcholinesterase (ACHE) Main DME DEQ2BAJ ACES_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interleukin-5 receptor subunit alpha (IL5RA) OTMSLUG9 IL5RA_HUMAN Drug Response [8]
Secreted Ly-6/uPAR-related protein 1 (SLURP1) OT89YD2E SLUR1_HUMAN Regulation of Drug Effects [9]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 294).
2 Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257-66.
3 Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem. 2013 Aug;126(4):451-61.
4 SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72.
5 Organic cation transporters: physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab. 2009 Jul;10(6):617-31.
6 Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res. 2006 Apr 12;7:65.
7 How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8 The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness. J Allergy Clin Immunol. 2002 Mar;109(3):404-9. doi: 10.1067/mai.2002.122459.
9 SLURP-1, an endogenous 7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205(+) dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity. J Neuroimmunol. 2014 Feb 15;267(1-2):43-9. doi: 10.1016/j.jneuroim.2013.12.003. Epub 2013 Dec 11.
10 Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70.
11 Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors. J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):177-84.
12 Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther. 2002 Oct;303(1):29-35.
13 Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther. 1998 Feb;284(2):500-7.
14 Effects of propiverine hydrochloride (propiverine) on the muscarinic receptor binding affinity in guinea pig tissues and on salivation in conscious dogs. Nihon Yakurigaku Zasshi. 1999 Mar;113(3):157-66.
15 Clinical pipeline report, company report or official report of GlaxoSmithKline.
16 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
17 The amygdala modulates morphine-induced state-dependent memory retrieval via muscarinic acetylcholine receptors. Neuroscience. 2009 May 5;160(2):255-63.
18 Competitive and non-competitive antagonism exhibited by 'selective' antagonists at atrial and ileal muscarinic receptor subtypes. Br J Pharmacol. 1987 Apr;90(4):701-7.
19 Long-acting bronchodilators in COPD: Where are we now and where are we going Breathe 06/2014; 10(2):110-120.
20 Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
21 Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52.
22 Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology. 2009 Oct;50(4):1227-40.
23 Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
24 Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem. 2010 Jul;114(1):142-9.
25 Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci. 2004 Mar 17;24(11):2846-51.
26 Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60.
27 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
28 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
29 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
30 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
31 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
32 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
33 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
34 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
35 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
36 Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2017 Oct 6;292(40):16526.
37 SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet. 2017 Jan 15;26(2):383-394.
38 Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine. Chem Biol Interact. 2018 Sep 25;293:107-114.
39 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
40 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
41 Changing the differentiation program of hematopoietic cells: retinoic acid-induced shift of eosinophil-committed cells to neutrophils. Blood. 1995 Nov 15;86(10):3737-44.
42 Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J Clin Invest. 1999 Sep;104(5):657-67. doi: 10.1172/JCI7137.
43 Interleukin-5 receptor alpha chain mRNA is down-regulated by transforming growth factor beta 1. Eur Cytokine Netw. 1994 Jan-Feb;5(1):35-42.
44 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.