Details of the Drug

General Information of Drug (ID: DMUMQZ0)

Drug Name
Clidinium
Synonyms
clidinium; N-Methyl quinuclidinyl benzilate; 7020-55-5; 3-hydroxy-1-methylquinuclidinium benzilate ester; 3-{[hydroxy(diphenyl)acetyl]oxy}-1-methyl-1-azoniabicyclo[222]octane; Ro-23773; 3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-azonia-bicyclo[222]octane; 1-Azoniabicyclo(222)octane, 3-((hydroxydiphenylacetyl)oxy)-1-methyl-; [3H]clidinium; (-)MQNB; Clidinium bromid; (1-methyl-1-azoniabicyclo[222]octan-8-yl) 2-hydroxy-2,2-di(phenyl)acetate; 3-Hydroxy-1-methylquinuclidinium benzilate (ester); Quinuclidinium,; Librax (TN); Benzilic acid, ester with 3-hydroxy-1-methylquinuclidinium; Quinuclidinium, 3-hydroxy-1-methyl-, benzilate (ester); (1-methyl-1-azoniabicyclo[222]octan-3-yl) 2-hydroxy-2,2-diphenylacetate
Indication
Disease Entry ICD 11 Status REF
Abdominal stomach pain DD91.4 Approved [1]
Irritable bowel syndrome DD91.0 Approved [1]
Therapeutic Class
Analgesics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 352.4
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C22H26NO3+
IUPAC Name
(1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate
Canonical SMILES
C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O
InChI
InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1
InChIKey
HOOSGZJRQIVJSZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2784
ChEBI ID
CHEBI:3743
CAS Number
7020-55-5
DrugBank ID
DB00771
TTD ID
D0Q1BT
VARIDT ID
DR01421
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor (CHRM) TTOXS3C NOUNIPROTAC Antagonist [2]
Muscarinic acetylcholine receptor M1 (CHRM1) TTZ9SOR ACM1_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Abdominal stomach pain
ICD Disease Classification DD91.4
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Muscarinic acetylcholine receptor M1 (CHRM1) DTT CHRM1 4.61E-07 -0.59 -0.73
Organic cation transporter 1 (SLC22A1) DTP SLC22A1 8.54E-01 1.24E-02 7.20E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Clidinium
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
R0-93877 DMM4U9G Moderate Antagonize the effect of Clidinium when combined with R0-93877. Irritable bowel syndrome [DD91] [5]
Dicyclomine DMZSDGX Moderate Additive anticholinergic effects by the combination of Clidinium and Dicyclomine. Irritable bowel syndrome [DD91] [6]
Coadministration of a Drug Treating the Disease Different from Clidinium (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Bethanechol DMCLHO0 Moderate Antagonize the effect of Clidinium when combined with Bethanechol. Abnormal micturition [MF50] [7]
Oliceridine DM6MDCF Moderate Additive antimotility effects by the combination of Clidinium and Oliceridine. Acute pain [MG31] [8]
Mepyramine DMB4SFH Moderate Additive anticholinergic effects by the combination of Clidinium and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [9]
Phenyltoloxamine DMKAEQW Moderate Additive anticholinergic effects by the combination of Clidinium and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [9]
Tripelennamine DMZBU15 Moderate Additive anticholinergic effects by the combination of Clidinium and Tripelennamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [6]
Memantine DMD9WSC Moderate Additive anticholinergic effects by the combination of Clidinium and Memantine. Alzheimer disease [8A20] [6]
Rivastigmine DMG629M Moderate Antagonize the effect of Clidinium when combined with Rivastigmine. Alzheimer disease [8A20] [10]
Donepezil DMIYG7Z Moderate Antagonize the effect of Clidinium when combined with Donepezil. Alzheimer disease [8A20] [10]
Desipramine DMT2FDC Moderate Additive anticholinergic effects by the combination of Clidinium and Desipramine. Attention deficit hyperactivity disorder [6A05] [6]
Cariprazine DMJYDVK Moderate Additive anticholinergic effects by the combination of Clidinium and Cariprazine. Bipolar disorder [6A60] [6]
Loperamide DMOJZQ9 Moderate Additive antimotility effects by the combination of Clidinium and Loperamide. Bowel habit change [ME05] [11]
Acetylcholine DMDF79Z Moderate Antagonize the effect of Clidinium when combined with Acetylcholine. Cataract [9B10] [12]
Umeclidinium DM4E8O9 Moderate Additive anticholinergic effects by the combination of Clidinium and Umeclidinium. Chronic obstructive pulmonary disease [CA22] [13]
Tiotropium DMFDC0Q Moderate Additive anticholinergic effects by the combination of Clidinium and Tiotropium. Chronic obstructive pulmonary disease [CA22] [13]
Revefenacin DMMP5SI Moderate Additive anticholinergic effects by the combination of Clidinium and Revefenacin. Chronic obstructive pulmonary disease [CA22] [13]
Dihydrocodeine DMB0FWL Moderate Additive CNS depression effects by the combination of Clidinium and Dihydrocodeine. Chronic pain [MG30] [14]
Alfentanil DMVO0UB Moderate Additive antimotility effects by the combination of Clidinium and Alfentanil. Corneal disease [9A76-9A78] [8]
Remifentanil DMZTXCH Moderate Additive antimotility effects by the combination of Clidinium and Remifentanil. Corneal disease [9A76-9A78] [8]
Arbutamine DMCY8AF Moderate Increased risk of rapid heart rate by the combination of Clidinium and Arbutamine. Coronary atherosclerosis [BA80] [15]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Clidinium and Ethanol. Cystitis [GC00] [16]
Cyclobenzaprine DM1YBRM Moderate Additive anticholinergic effects by the combination of Clidinium and Cyclobenzaprine. Depression [6A70-6A7Z] [6]
OPC-34712 DMHG57U Moderate Additive anticholinergic effects by the combination of Clidinium and OPC-34712. Depression [6A70-6A7Z] [6]
Clomipramine DMINRKW Moderate Additive anticholinergic effects by the combination of Clidinium and Clomipramine. Depression [6A70-6A7Z] [6]
Doxepin DMPI98T Moderate Additive anticholinergic effects by the combination of Clidinium and Doxepin. Depression [6A70-6A7Z] [6]
Maprotiline DMPWB7T Moderate Additive anticholinergic effects by the combination of Clidinium and Maprotiline. Depression [6A70-6A7Z] [6]
Mepenzolate DM8YU2F Moderate Additive anticholinergic effects by the combination of Clidinium and Mepenzolate. Digestive system disease [DE2Z] [6]
Oxybutynine DMJPBAX Moderate Additive anticholinergic effects by the combination of Clidinium and Oxybutynine. Discovery agent [N.A.] [6]
Zonisamide DM0DTF7 Major Increased risk of hyperpyrexia by the combination of Clidinium and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [17]
Diphenhydramine DMKQTBA Moderate Additive anticholinergic effects by the combination of Clidinium and Diphenhydramine. Episodic vestibular syndrome [AB31] [6]
Nadolol DMW6GVL Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Nadolol. Essential hypertension [BA00] [18]
Solifenacin DMG592Q Moderate Additive anticholinergic effects by the combination of Clidinium and Solifenacin. Functional bladder disorder [GC50] [6]
Tolterodine DMSHPW8 Moderate Additive anticholinergic effects by the combination of Clidinium and Tolterodine. Functional bladder disorder [GC50] [6]
Ketoconazole DMPZI3Q Moderate Decreased absorption of Clidinium due to altered gastric pH caused by Ketoconazole. Fungal infection [1F29-1F2F] [19]
Propantheline DM2EN6G Moderate Additive anticholinergic effects by the combination of Clidinium and Propantheline. Gastric ulcer [DA60] [6]
Pilocarpine DMV9ADG Moderate Antagonize the effect of Clidinium when combined with Pilocarpine. Glaucoma [9C61] [7]
Carvedilol DMHTEAO Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Carvedilol. Heart failure [BD10-BD1Z] [18]
Chlorothiazide DMLHESP Minor Altered absorption of Clidinium due to GI dynamics variation caused by Chlorothiazide. Heart failure [BD10-BD1Z] [20]
Hydroflumethiazide DMVPUQI Minor Altered absorption of Clidinium due to GI dynamics variation caused by Hydroflumethiazide. Heart failure [BD10-BD1Z] [20]
Acebutolol DM0TI4U Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Acebutolol. Hypertension [BA00-BA04] [18]
Penbutolol DM4ES8F Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Penbutolol. Hypertension [BA00-BA04] [18]
Nebivolol DM7F1PA Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Nebivolol. Hypertension [BA00-BA04] [18]
Pindolol DMD2NV7 Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Pindolol. Hypertension [BA00-BA04] [18]
Indapamide DMGN1PW Minor Altered absorption of Clidinium due to GI dynamics variation caused by Indapamide. Hypertension [BA00-BA04] [20]
Trichlormethiazide DMHAQCO Minor Altered absorption of Clidinium due to GI dynamics variation caused by Trichlormethiazide. Hypertension [BA00-BA04] [20]
Hydrochlorothiazide DMUSZHD Minor Altered absorption of Clidinium due to GI dynamics variation caused by Hydrochlorothiazide. Hypertension [BA00-BA04] [20]
Belladonna DM2RBWK Moderate Additive anticholinergic effects by the combination of Clidinium and Belladonna. Infectious gastroenteritis/colitis [1A40] [6]
Amantadine DMS3YE9 Moderate Additive anticholinergic effects by the combination of Clidinium and Amantadine. Influenza [1E30-1E32] [21]
Propiomazine DMKY8V1 Moderate Additive anticholinergic effects by the combination of Clidinium and Propiomazine. Insomnia [7A00-7A0Z] [6]
ITI-007 DMUQ1DO Moderate Additive anticholinergic effects by the combination of Clidinium and ITI-007. Insomnia [7A00-7A0Z] [6]
Physostigmine DM2N0TO Moderate Antagonize the effect of Clidinium when combined with Physostigmine. Lips/oral mucosa miscellaneous disorder [DA02] [10]
Neostigmine DM6T2J3 Moderate Antagonize the effect of Clidinium when combined with Neostigmine. Myasthenia gravis [8C6Y] [22]
Edrophonium DMCRQHB Moderate Antagonize the effect of Clidinium when combined with Edrophonium. Myasthenia gravis [8C6Y] [22]
Ambenonium DMOP0BL Moderate Antagonize the effect of Clidinium when combined with Ambenonium. Myasthenia gravis [8C6Y] [22]
Phenindamine DMDTC7R Moderate Additive anticholinergic effects by the combination of Clidinium and Phenindamine. Nasopharyngitis [CA00] [6]
Dimenhydrinate DM264B3 Moderate Additive anticholinergic effects by the combination of Clidinium and Dimenhydrinate. Nausea/vomiting [MD90] [6]
Promethazine DM6I5GR Moderate Additive anticholinergic effects by the combination of Clidinium and Promethazine. Nausea/vomiting [MD90] [6]
Cyclizine DM9G7BS Moderate Additive anticholinergic effects by the combination of Clidinium and Cyclizine. Nausea/vomiting [MD90] [6]
Metoclopramide DMFA5MY Moderate Antagonize the effect of Clidinium when combined with Metoclopramide. Nausea/vomiting [MD90] [23]
Polythiazide DMCH80F Minor Altered absorption of Clidinium due to GI dynamics variation caused by Polythiazide. Oedema [MG29] [20]
Levomethadyl Acetate DM06HG5 Moderate Additive CNS depression effects by the combination of Clidinium and Levomethadyl Acetate. Opioid use disorder [6C43] [14]
Oxymorphone DM65AGJ Moderate Additive antimotility effects by the combination of Clidinium and Oxymorphone. Pain [MG30-MG3Z] [8]
Levorphanol DMGS80V Moderate Additive antimotility effects by the combination of Clidinium and Levorphanol. Pain [MG30-MG3Z] [8]
Dezocine DMJDB0Y Moderate Additive antimotility effects by the combination of Clidinium and Dezocine. Pain [MG30-MG3Z] [8]
Flavoxate DMKV4NL Moderate Additive anticholinergic effects by the combination of Clidinium and Flavoxate. Pain [MG30-MG3Z] [6]
Nalbuphine DMOSQGU Moderate Additive antimotility effects by the combination of Clidinium and Nalbuphine. Pain [MG30-MG3Z] [8]
Buprenorphine DMPRI8G Moderate Additive antimotility effects by the combination of Clidinium and Buprenorphine. Pain [MG30-MG3Z] [8]
Hydrocodone DMQ2JO5 Moderate Additive antimotility effects by the combination of Clidinium and Hydrocodone. Pain [MG30-MG3Z] [8]
Biperiden DME78OA Moderate Additive anticholinergic effects by the combination of Clidinium and Biperiden. Parkinsonism [8A00] [6]
Levodopa DMN3E57 Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Levodopa. Parkinsonism [8A00] [24]
Orphenadrine DMW542E Moderate Additive anticholinergic effects by the combination of Clidinium and Orphenadrine. Parkinsonism [8A00] [6]
Methylscopolamine DM5VWOB Moderate Additive anticholinergic effects by the combination of Clidinium and Methylscopolamine. Peptic ulcer [DA61] [6]
Levomepromazine DMIKFEL Moderate Additive anticholinergic effects by the combination of Clidinium and Levomepromazine. Psychotic disorder [6A20-6A25] [6]
Quetiapine DM1N62C Moderate Additive anticholinergic effects by the combination of Clidinium and Quetiapine. Schizophrenia [6A20] [6]
Mesoridazine DM2ZGAN Moderate Additive anticholinergic effects by the combination of Clidinium and Mesoridazine. Schizophrenia [6A20] [6]
Aripiprazole DM3NUMH Moderate Additive anticholinergic effects by the combination of Clidinium and Aripiprazole. Schizophrenia [6A20] [6]
Iloperidone DM6AUFY Moderate Additive anticholinergic effects by the combination of Clidinium and Iloperidone. Schizophrenia [6A20] [6]
Paliperidone DM7NPJS Moderate Additive anticholinergic effects by the combination of Clidinium and Paliperidone. Schizophrenia [6A20] [6]
Perphenazine DMA4MRX Moderate Additive anticholinergic effects by the combination of Clidinium and Perphenazine. Schizophrenia [6A20] [6]
Molindone DMAH70G Moderate Additive anticholinergic effects by the combination of Clidinium and Molindone. Schizophrenia [6A20] [6]
Thiothixene DMDINC4 Moderate Additive anticholinergic effects by the combination of Clidinium and Thiothixene. Schizophrenia [6A20] [6]
Trifluoperazine DMKBYWI Moderate Additive anticholinergic effects by the combination of Clidinium and Trifluoperazine. Schizophrenia [6A20] [6]
Asenapine DMSQZE2 Moderate Additive anticholinergic effects by the combination of Clidinium and Asenapine. Schizophrenia [6A20] [6]
Pimozide DMW83TP Moderate Additive anticholinergic effects by the combination of Clidinium and Pimozide. Schizophrenia [6A20] [6]
Fentanyl DM8WAHT Moderate Additive antimotility effects by the combination of Clidinium and Fentanyl. Sensation disturbance [MB40] [8]
Pramlintide DM0EZ9Q Moderate Altered absorption of Clidinium due to GI dynamics variation caused by Pramlintide. Type-1/2 diabete [5A10-5A11] [25]
Chlorpheniramine DM5URA2 Moderate Additive anticholinergic effects by the combination of Clidinium and Chlorpheniramine. Vasomotor/allergic rhinitis [CA08] [6]
Methdilazine DMAUHQX Moderate Additive anticholinergic effects by the combination of Clidinium and Methdilazine. Vasomotor/allergic rhinitis [CA08] [6]
Trimeprazine DMEMV9D Moderate Additive anticholinergic effects by the combination of Clidinium and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [9]
Brompheniramine DMFOVSD Moderate Additive anticholinergic effects by the combination of Clidinium and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [6]
Acrivastine DMTIGA0 Moderate Additive anticholinergic effects by the combination of Clidinium and Acrivastine. Vasomotor/allergic rhinitis [CA08] [6]
⏷ Show the Full List of 90 DDI Information of This Drug

References

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