Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDL27I)

• Drug Name: Oxytocin Drug Info
• Synonyms: OXYTOCIN; Pitocin; 50-56-6; Ocytocin; Endopituitrina; Orasthin; Syntocinon; Oxytocine; Oxitocina; Oxytocinum; (1-Hemicystine)oxytocin; Piton S; Oxytocic hormone; UNII-1JQS135EYN; 3-Isoleucine-8-leucine vasopressin; Partocon; Oxystin; alpha-Hypophamine; Synthetic oxytocin; 1JQS135EYN; Ocytocinum; Syntocinone; Utedrin; Oxtocin; Uteracon; Syntocin; Synpitan; Presoxin; Di-sipidin; CHEMBL395429; CHEBI:7872; Nobitocin S; Atonin O; Oxetakain [Czech]; Ossitocina [DCIT]; Oxytocine [INN-French]; Oxytocinum [INN-Latin]; Oxitocina [INN-Spanish]; Posterior; Oxytocin (intranasal/ muco system, autism); [3H]OT (human, mouse, rat)

Indication

Disease Entry	ICD 11	Status	REF
Autism spectrum disorder	6A02	Approved	[1]
Ductal breast carcinoma in situ		Approved	[2]
Postpartum haemorrhage	JA43	Approved	[2]
Lactation failure	JB46.3	Phase 3	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]

• Cross-matching ID:
  PubChem CID: 439302
  ChEBI ID: CHEBI:7872
  CAS Number: CAS 50-56-6
  TTD Drug ID: DMDL27I
  VARIDT Drug ID: DR01199
  ACDINA Drug ID: D01310

Molecule-Related Drug Atlas

Drug(s) Targeting Vasopressin V1b receptor (V1BR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[10]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[11]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[12]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[13]
ABT-436	DMNAU1V	Anxiety disorder	6B00-6B0Z	Phase 2	[14]
ARGENINE VASOPRESSIN	DM8KN0Q	Discovery agent	N.A.	Investigative	[15]
D[Arg4,Orn8]VP	DM8D4QT	Discovery agent	N.A.	Investigative	[15]
D[Leu4,Lys8]VP	DMDBU7Q	Discovery agent	N.A.	Investigative	[15]
D[Arg4,Lys8]VP	DM69OVM	Discovery agent	N.A.	Investigative	[15]
D[Cha4,Lys8]VP	DM0GO7U	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Vasopressin V2 receptor (V2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[10]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[16]
Tolvaptan	DMIWFRL	Autosomal dominant polycystic kidney disease	GB81	Approved	[17]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[18]
Vasopressin	DMQ2FPC	Diabetes insipidus	5A61.5	Approved	[19]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[12]
Lixivaptan	DMDN4ZP	Hyponatraemia	5C72	Phase 3	[20]
Satavaptan	DME5PN3	Acute and chronic heart failure	BD1Z	Phase 3	[21]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[22]
ASP-7035	DMTF24A	Nocturia	MF55	Phase 2	[23]

Drug(s) Targeting Vasopressin V1a receptor (V1AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[10]
Mozavaptan	DMZ905C	Hyponatraemia	5C72	Approved	[24]
Conivaptan	DM1V329	Euvolemic hyponatremia	5C72	Approved	[18]
Felypressin	DMHLP9C	Localisation	N.A.	Approved	[25]
Terlipressin	DMT9FH3	Hypertension	BA00-BA04	Approved	[26]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[12]
Balovaptan	DMKMTDG	Autism spectrum disorder	6A02	Phase 3	[27]
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[28]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[22]
VA-111913	DMAYWXD	Dysmenorrhea	GA34.3	Phase 2	[29]

Drug(s) Targeting Oxytocin receptor (OTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desmopressin	DMS3GVE	Diabetic complication	5A2Y	Approved	[10]
Carbetocin	DMUSLW3	Postpartum haemorrhage	JA43	Approved	[25]
ATOSIBAN	DMB7WYM	N. A.	N. A.	Phase 4	[30]
Retosiban	DMOYGZF	Preterm labour	JB00	Phase 3	[31]
SSR149415	DMCMD93	Anxiety disorder	6B00-6B0Z	Phase 2	[22]
Barusiban	DMWI0X3	Androgen deficiency	5A81.1	Phase 2	[32]
FE-202767	DMDGZ1C	Erectile dysfunction	HA01.1	Phase 2	[5]
GSK-557296	DM3ZL2O	Premature ejaculation	HA03.0Z	Phase 2	[33]
Pyrrolidine derivative 13	DM3VA8P	N. A.	N. A.	Patented	[34]
PMID28906174-Compound-figure1g	DMECU90	N. A.	N. A.	Patented	[34]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxytocin receptor (OTR)	TTSCIUP	OXYR_HUMAN	Modulator	[5]
Vasopressin V1a receptor (V1AR)	TT4TFGN	V1AR_HUMAN	Agonist	[6]
Vasopressin V1b receptor (V1BR)	TTL9MHW	V1BR_HUMAN	Agonist	[7]
Vasopressin V2 receptor (V2R)	TTK8R02	V2R_HUMAN	Agonist	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Gene/Protein Processing	[9]

References

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• [2] Oxytocin FDA Label
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