Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDMNQV)

Drug Name

6-Hydroxyuridine-5'-Phosphate Drug Info

Synonyms

6-hydroxy-UMP; 6-HYDROXYURIDINE-5'-PHOSPHATE; 6-hydroxyuridine 5'-(dihydrogen phosphate); CHEMBL383923; 29741-00-2; Prfb acid; 1lor; 1dqx; 1eix; 6-hydroxyuridine 5'-phosphate; AC1Q69HY; AC1L4PT5; 5'-Uridylic acid,6-hydroxy-; SCHEMBL2130675; 5'-Uridylic acid, 6-hydroxy-; CTK4G3746; DTXSID50183892; Phosphoribofuranosylbarbituric acid; BDBM50199178; 6-Hydroxyuridine 5'-phosphoric acid; DB02890; 6-HYDROXYURIDINE-5''-PHOSPHATE; Barbituric acid ribonucleoside 5'-phosphate; 1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5''-monophosp

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 161647
CAS Number: CAS 29741-00-2
TTD Drug ID: DMDMNQV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Orotidine 5'-monophosphate decarboxylase (UMPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[2]
Pyrazofurin	DMVJLSM	Discovery agent	N.A.	Investigative	[3]
5-fluoro-6-azido-UMP	DMZLJRS	Discovery agent	N.A.	Investigative	[4]
5-fluoro-6-amino-UMP	DM6QHIA	Discovery agent	N.A.	Investigative	[4]
5-fluoro-6-iodo-UMP	DM3LMIS	Discovery agent	N.A.	Investigative	[4]
5-Fluoro-6-ethyluridine-5'-O-monophosphate	DMTAZ71	Discovery agent	N.A.	Investigative	[4]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Targeting Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Uridine-5'-Monophosphate	DMG1NM7	Discovery agent	N.A.	Investigative	[1]
6-aza-uridine monophosphate	DM7WYCM	Discovery agent	N.A.	Investigative	[5]
Xanthosine-5'-monophosphate disodium salt	DM1GJX8	Discovery agent	N.A.	Investigative	[6]
6-amino-uridine monophosphate	DMUZOYN	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF)	TTV7Y40	PYRF_MYCTO	Inhibitor	[1]
Orotidine 5'-monophosphate decarboxylase (UMPS)	TTAFJUD	UMPS_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.
4	Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58.
5	Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem. 2006 Aug 10;49(16):4937-45.
6	Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase. J Med Chem. 2008 Feb 14;51(3):432-8.