Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME8VPC)

• Drug Name: 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine Drug Info
• Synonyms: CHEMBL215655

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 16043019
  TTD Drug ID: DME8VPC

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-2 (GABRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[2]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[1]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[3]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[1]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[2]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[4]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[5]
CGS-17867A	DMMZJY3	Alcohol dependence	6C40.2	Terminated	[6]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[7]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Strychnine-binding glycine receptor (GLRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[1]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[9]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[10]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine	DMXFVD1	Discovery agent	N.A.	Investigative	[1]
3-demethoxy-3-L-fucopyranosylaminothiocolchicine	DM4ERYF	Discovery agent	N.A.	Investigative	[1]
3-demethoxy-3D-glucopyranosylaminothiocolchicine	DMID7TC	Discovery agent	N.A.	Investigative	[1]
3-demethoxy-3-D-mannopyranosylaminothiocolchicine	DMALMGH	Discovery agent	N.A.	Investigative	[1]
GINKGOLIDE A	DMKZJ7T	Discovery agent	N.A.	Investigative	[10]
Ginkgolide J	DMUOMP1	Discovery agent	N.A.	Investigative	[10]
Ginkgolide C	DMVN374	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[11]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[12]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[11]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[11]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[2]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[11]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[11]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[1]
Meprobamate	DMHM93Y	Anxiety		Approved	[11]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[13]

Drug(s) Targeting Glycine receptor (GlyR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[1]
ZD-9379	DM3KYO4	Cerebrovascular ischaemia	8B1Z	Phase 1	[14]
UK-240455	DMSCXB7	Nerve injury	ND56.4	Phase 1	[15]
MDL-27531	DMC60S8	Epilepsy	8A60-8A68	Phase 1	[16]
Gavestinel	DM8IL1U	Nerve injury	ND56.4	Discontinued in Phase 2	[17]
GV-196771	DMFN21T	Migraine	8A80	Discontinued in Phase 2	[18]
GW 468816	DMQ92WF	Tobacco dependence	6C4A.2	Discontinued in Phase 2	[19]
M-241247	DMIY51U	Cerebrovascular ischaemia	8B1Z	Terminated	[20]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[10]
3-demethoxy-3-D-xylopyranosylaminothiocolchicine	DMXFVD1	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[11]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[21]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[1]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[22]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[23]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[24]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[25]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[26]
ANDROSTERONE	DMITJAK	N. A.	N. A.	Phase 3	[21]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[3]

Drug(s) Targeting GABA(A) receptor beta-2 (GABRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[2]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[1]
Ethchlorvynol	DM53IP1	Insomnia	7A00-7A0Z	Approved	[11]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[3]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[1]
ELTANOLONE	DM38CIV	Premenstrual syndrome	GA34.40	Discontinued in Phase 3	[2]
U-78875	DM2WOPX	Anxiety disorder	6B00-6B0Z	Discontinued in Phase 1	[27]
CGS-9896	DM39PQI	N. A.	N. A.	Terminated	[5]
TBPS	DMFC3XP	Discovery agent	N.A.	Investigative	[28]
AMENTOFLAVONE	DMLRNV2	Discovery agent	N.A.	Investigative	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Inhibitor	[1]
GABA(A) receptor beta-2 (GABRB2)	TTZA1NY	GBRB2_HUMAN	Inhibitor	[1]
GABA(A) receptor gamma-2 (GABRG2)	TT06RH5	GBRG2_HUMAN	Inhibitor	[1]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[1]
Glycine receptor (GlyR)	TTZ8EM9	GLRA1_HUMAN; GLRA2_HUMAN; GLRA3_HUMAN; GLRA4_HUMAN; GLRB_HUMAN	Inhibitor	[1]
Strychnine-binding glycine receptor (GLRA1)	TTF45NW	GLRA1_HUMAN	Inhibitor	[1]

References

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• [21] Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605.
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