Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFGOW0)

• Drug Name: NAAG Drug Info
• Synonyms: N-acetylaspartylglutamate; spaglumic acid; isospaglumic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 188803
  ChEBI ID: CHEBI:73688
  CAS Number: CAS 3106-85-2
  TTD Drug ID: DMFGOW0
  VARIDT Drug ID: DR01243

Molecule-Related Drug Atlas

Drug(s) Targeting Metabotropic glutamate receptor 3 (mGluR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY404039	DMWZIRJ	Schizophrenia	6A20	Phase 3	[6]
RO-4995819	DMNTC7O	Major depressive disorder	6A70.3	Phase 2	[7]
Oleoyl-estrone	DM0RA8F	Alzheimer disease	8A20	Phase 2	[8]
MP-101	DMYCITZ	Alzheimer disease	8A20	Phase 2	[9]
BCI-838	DMRXDN3	Major depressive disorder	6A70.3	Phase 1	[10]
Pomaglumetad	DMTOLI5	Schizophrenia	6A20	Phase 1	[11]
BCI-632	DMZYCWT	Alzheimer disease	8A20	Phase 1	[12]
PMID25435285-Compound-16	DMKFX2G	N. A.	N. A.	Patented	[13]
PMID25435285-Compound-15	DMHBWNS	N. A.	N. A.	Patented	[13]
PMID25435285-Compound-20	DMG9FYH	N. A.	N. A.	Patented	[13]

Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[14]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[15]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[16]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[17]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[18]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[19]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[20]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[15]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[17]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[17]

Drug(s) Transported By Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NITRATE	DMVFB93	Discovery agent	N.A.	Investigative	[21]

Drug(s) Affected By Glutamate carboxypeptidase 2 (FOLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Pentobarbital	DMFNH7L	Brain ischaemia	8B1Z	Approved	[25]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[26]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[27]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[28]
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	DMDJYHK	Discovery agent	N.A.	Investigative	[29]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[26]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 3 (mGluR3)	TT8A9EF	GRM3_HUMAN	Agonist	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5)	DTWLACT	S17A5_HUMAN	Substrate	[3]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Glutamate carboxypeptidase 2 (FOLH1)	OTQ9Z6QK	FOLH1_HUMAN	Protein Interaction/Cellular Processes	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1405).
• [2] Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6.
• [3] Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8.
• [4] Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66.
• [5] Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer. Nucl Med Biol. 2014 Apr;41(4):355-63. doi: 10.1016/j.nucmedbio.2014.01.001. Epub 2014 Jan 10.
• [6] Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia. Expert Opin Ther Pat. 2009 Sep;19(9):1259-75.
• [7] Novel glutamatergic drugs for the treatment of mood disorders. Neuropsychiatr Dis Treat. 2013; 9: 1101-1112.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] ClinicalTrials.gov (NCT03044249) A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression. U.S. National Institutes of Health.
• [10] Metabotropic glutamate receptor subtype 2 (GRM2; MGLUR2); GRM3 (MGLUR3). SciBX 3(13); doi:10.1038/scibx.2010.413. April 1 2010
• [11] LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia. Curr Opin Investig Drugs. 2010 Jul;11(7):833-45.
• [12] Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. J Med Chem. 2004 Aug 26;47(18):4570-87.
• [13] Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90.
• [14] Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55.
• [15] Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18.
• [16] Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
• [17] High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
• [18] The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
• [19] Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
• [20] Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61.
• [21] Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9.
• [22] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [23] 1alpha,25-Dihydroxyvitamin D3 down-regulates expression of prostate specific membrane antigen in prostate cancer cells. Prostate. 2008 May 15;68(7):773-83. doi: 10.1002/pros.20739.
• [24] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [25] [Development of oral vaccine carrying GCPII gene and its role in reducing the dosage of pentobarbital in rat: a primitive research]. Zhonghua Yi Xue Za Zhi. 2004 Jul 17;84(14):1152-6.
• [26] Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds. J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):231-8. doi: 10.1016/s0960-0760(03)00033-5.
• [27] Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007 May 15;67(10):5033-41.
• [28] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [29] The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines. J Biochem Mol Toxicol. 2016 May;30(5):239-42. doi: 10.1002/jbt.21784. Epub 2016 Jan 5.