Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGJMQH)

Drug Name

Examorelin Drug Info

Synonyms

Hexarelin; EP-23905; MF-6003

Indication

Disease Entry	ICD 11	Status	REF
Growth hormone deficiency	5A61.3	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 6918297
CAS Number: CAS 140703-51-1
TTD Drug ID: DMGJMQH

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Growth hormone-releasing hormone receptor (GHRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sermorelin	DM25HP1	Pediatric growth disorder	FB86	Approved	[4]
Tesamorelin	DM9GP85	HIV-associated lipodystrophy	1C62.1	Approved	[5]
AKL-0707	DME6OXB	Lipodystrophy	EF01	Discontinued in Phase 2	[6]
L-692429	DMLHE5A	Growth hormone deficiency	5A61.3	Discontinued in Phase 1	[7]
NNC-26-0762	DMLTYFI	Growth hormone deficiency	5A61.3	Terminated	[8]
Mutated growth hormone	DMAY50R	Acromegaly	5A60.0	Investigative	[9]
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Drug(s) Affected By Somatotropin (GH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[10]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[11]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[12]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Sodium oxybate	DMBOV5P	Narcolepsy	7A20	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[10]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[16]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[17]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[18]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Growth hormone-releasing hormone receptor (GHRHR)	TTG4R8V	GHRHR_HUMAN	Modulator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Protein Interaction/Cellular Processes	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1100).
2	Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa. J Endocrinol Invest. 1997 May;20(5):257-63.
3	The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency. J Clin Endocrinol Metab. 1995 Sep;80(9):2692-6. doi: 10.1210/jcem.80.9.7673411.
4	Sermorelin: a better approach to management of adult-onset growth hormone insufficiency Clin Interv Aging. 2006;1(4):307-8.
5	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
6	A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease. Kidney Int. 2010 Mar;77(5):450-8.
7	Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrel... Mol Endocrinol. 2005 Sep;19(9):2400-11.
8	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010046)
9	Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90.
10	Metal-catalyzed oxidation of human growth hormone: modulation by solvent-induced changes of protein conformation. J Pharm Sci. 2001 Jan;90(1):58-69. doi: 10.1002/1520-6017(200101)90:1<58::aid-jps7>3.0.co;2-w.
11	Assessment of MK-912, an alpha 2-adrenoceptor antagonist, with use of intravenous clonidine. Clin Pharmacol Ther. 1989 Jul;46(1):103-9. doi: 10.1038/clpt.1989.113.
12	Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. J Biol Chem. 2003 Feb 21;278(8):6075-84. doi: 10.1074/jbc.M204702200. Epub 2002 Dec 5.
13	[Toxicity of cyproheptadine. Side effects and accidental overdosage (author's transl)]. Monatsschr Kinderheilkd (1902). 1978 Mar;126(3):123-6.
14	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
15	Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.
16	Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans. Hypertension. 1984 Sep-Oct;6(5 Pt 2):II57-62. doi: 10.1161/01.hyp.6.5_pt_2.ii57.
17	Thyrotropin-releasing hormone-induced GH release after cocaine withdrawal in cocaine addicts. Neuropeptides. 1999 Dec;33(6):522-5. doi: 10.1054/npep.1999.0773.
18	Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteers. Addict Behav. 2005 May;30(4):859-64. doi: 10.1016/j.addbeh.2004.08.019.